IL21 Receptor Antikörper (Extracellular Domain)

Produktnummer ABIN360918

Der Ratte Monoklonal anti-IL21 Receptor Antikörper (Klon 7F27) (ABIN360918) detektiert spezifisch IL21 Receptor in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Maus.

Kurzübersicht für IL21 Receptor Antikörper (Extracellular Domain) (ABIN360918)

Target: IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser IL21 Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 7F27

Produktdetails anti-IL21 Receptor Antikörper

Bindungsspezifität: Extracellular Domain

Spezifität: This antibody detects IL-21R.

Aufreinigung: Protein A/G affinity chromatography

Immunogen: Recombinant protein of IL-21R extracellular domain.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore with 200 μL sterile PBS and the final concentration is 500 μg/mL.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu IL21 Receptor

Target: IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))

Andere Bezeichnung: Interleukin-21 Receptor / IL21R

Hintergrund: IL21 Receptor is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2 (IL2) and interleukin 5 (IL5). This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants encoding the same protein have been described.Synonyms: IL-21R, IL21 receptor, NILR, Novel interleukin receptor

Gen-ID: 50615

NCBI Accession: NP_068570

UniProt: Q9HBE5

Pathways: JAK-STAT Signalweg