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CD161 Antikörper

KLRB1 Reaktivität: Human FACS, IP, IHC (fro) Wirt: Maus Monoclonal B199-2 unconjugated
Produktnummer ABIN319957
  • Target Alle CD161 (KLRB1) Antikörper anzeigen
    CD161 (KLRB1) (Killer Cell Lectin-Like Receptor Subfamily B, Member 1 (KLRB1))
    Reaktivität
    • 58
    • 15
    • 6
    • 3
    • 2
    • 2
    Human
    Wirt
    • 54
    • 17
    Maus
    Klonalität
    • 53
    • 18
    Monoklonal
    Konjugat
    • 27
    • 11
    • 8
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CD161 Antikörper ist unkonjugiert
    Applikation
    • 49
    • 24
    • 12
    • 11
    • 10
    • 9
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Spezifität
    This antibody recognises the CD161 cell surface antigen. Clone B199.2 recognises a similar epitope to the DX9 monoclonal antibody.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human.
    Aufreinigung
    Affinity Chromatography on Protein G.
    Immunogen
    Spleen cells from immunised BALB/c mice were fused with cells of the mouse P2X63.Ag8.653 myeloma cell line.
    Klon
    B199-2
    Isotyp
    IgG1
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  • Applikationshinweise
    Flow Cytometry: Use 10 μL of 1/50-1/100 diluted antibody to label 10^6 cells in 100 μL. Immunoprecipitation. Immunohistochemistry on Frozen Sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    PBS, pH 7.4, 0.09 % Sodium Azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    CD161 (KLRB1) (Killer Cell Lectin-Like Receptor Subfamily B, Member 1 (KLRB1))
    Andere Bezeichnung
    CD161 / KLRB1 (KLRB1 Produkte)
    Synonyme
    NKR-P1 antikoerper, KLRB1 antikoerper, 4930431A04Rik antikoerper, Gm4696 antikoerper, Klrb1g antikoerper, Klrb6 antikoerper, Ly-55 antikoerper, Ly55 antikoerper, NKR-P1G antikoerper, Nkrp-1e antikoerper, Nkrp1g antikoerper, CD161 antikoerper, CLEC5B antikoerper, NKR antikoerper, NKR-P1A antikoerper, NKRP1A antikoerper, hNKR-P1A antikoerper, Klrb1d antikoerper, Klrb1f antikoerper, Nkr-p1e antikoerper, killer cell lectin like receptor B1 antikoerper, killer cell lectin-like receptor subfamily B member 1 antikoerper, killer cell lectin-like receptor subfamily B, member 1 antikoerper, KLRB1 antikoerper, Klrb1 antikoerper
    Hintergrund
    Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 (CD161) protein contains an extracellular domain with several motifs characteristic of C type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. In mouse the NKRP1 family has three members, NKRP1A, B and C, whilst in human only one member has been identified. The human protein has received the designation CD161, and the mouse proteins have been referred to as CD161a, b and c. Engagement of CD161c has been reported to have activating function in NK cells, whilst engagement of CD161b is inhibitory. CD161 is expressed by almost all NK cells and with a small subset of CD3+ve T cells. CD161 is a homodimeric cell surface protein, comprising two chains of 40-44kD.Synonyms: C-type lectin domain family 5 member B, CLEC5B, HNKR-P1a, Killer cell lectin-like receptor subfamily B member 1, NKRP1A, Natural killer cell surface protein P1A
    Gen-ID
    3820
    NCBI Accession
    NP_002249
    UniProt
    Q12918
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