Wiskott-Aldrich Syndrome (Eczema-thrombocytopenia) (WAS) Antikörper

Antigen: Wiskott-Aldrich Syndrome (Eczema-thrombocytopenia) (WAS)

Synonyme: THC, IMD2, THC1, WASP

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Enzyme Immunoassay (EIA), Immunhistochemie (Paraffinschnitte) (IHC (p)), Western Blot (WB)

Produktnummer: ABIN272092

Produktbeschreibung

Produktmerkmale: Synonyms: Wiskott-Aldrich syndrome protein, WASp

Weitere Bezeichnung: WAS / IMD2

Swiss-Prot: P42768

Kreuzreaktivität: Human, Maus

Beschreibung: The Wiskott-Aldrich syndrome (WAS) is a disorder that results from a monogenic defectthat has been mapped to the short arm of the X chromosome at Xp11. 23. WAS ischaracterized by thrombocytopenia, eczema, defects in cell-mediated and humoralimmunity and a propensity for lymphoproliferative disease. The gene that is mutated in thesyndrome encodes a 53 kDa proline-rich protein of unknown function designated WASprotein (WASP). A clue to WASP function came from the observation that T cells fromaffected males had an irregular cellular morphology and a disarrayed cytoskeletonsuggesting the involvement of WASP in cytoskeletal organization. Close examination of theWASP sequence revealed a putative Cdc42/Rac interacting domain, homologous withthose found in PAK65 and ACK. Subsequent investigation has shown WASP to be a truedownstream effector of Cdc42.

Spezifität: This antibody detects endogenous levels of WASP protein. Species: Human, Mouse. Others not tested. Add. Information: Molecular Weight: ~60 kDa

Anwendungen

Applikationshinweise: ELISA: 1/5000-1/10000. Western Blot: 1/500-1/1000. Immunohistochemistry on Paraffin Sections: 1/50-1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Konzentration: 1.0 mg/ml

Reinigung: Aff - Purified

Buffer: PBS, pH~7.2 containing 15 mM Sdium Azide as preservative.

Lagerung: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Beschränkungen: Nur für Forschungszwecke einsetzbar