DcR2 Antikörper (N-Term)

Produktnummer ABIN238513

Dieser Maus Monoklonal Antikörper detektiert spezifisch DcR2 in FACS. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für DcR2 Antikörper (N-Term) (ABIN238513)

Target: DcR2 (TNFRSF10D) (Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser DcR2 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Klon: TRAIL-R4-01

Produktdetails anti-DcR2 Antikörper

Bindungsspezifität: AA 1-210, N-Term

Spezifität: This antibody reacts with TRAIL-R4, a 42 kDa transmembrane protein expressed on various blood cells.

Kreuzreaktivität (Details): Species reactivity (tested):Human

Produktmerkmale: Synonyms: TNFRSF10D, DCR2, TRAIL-R4, TRUNDD, Decoy receptor 2, TRAIL receptor 4, Tumor necrosisfactor receptor superfamily member 10D, TNF-related apoptosis-inducing ligand receptor 4,TRAIL receptor with a truncated death domain

Aufreinigung: Protein A affinity chromatography

Immunogen: TRAIL-R4 (aa 1-210) - hIgGhc fusion protein.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Suitable for use in Flow Cytometry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS, pH 7.4 without preservatives

Konservierungsmittel: Without preservative

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid freeze/thaw cycles.
Shelf life: One year from despatch.

Haltbarkeit: 12 months

Details zu DcR2

Target: DcR2 (TNFRSF10D) (Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D))

Andere Bezeichnung: CD264 / TRAILR4

Hintergrund: TRAIL-R4 (CD264, TR4, DcR2, TRUNDD), expressed mainly on CD8+ and NK cells, belongs to receptors of TRAIL, a TNF-like membrane toxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R4, however, contains partially truncated death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing. TRAIL-R4 interacts with death receptor 5 (DR5) in the native DISC in a TRAIL-dependent manner and prevents its corecruitment with death receptor 4 (DR4).Synonyms: DCR2, Decoy receptor 2, TNF-related apoptosis-inducing ligand receptor 4, TNFRSF10D, TRAIL receptor 4, TRAIL receptor with a truncated death domain, TRAIL-R4, TRUNDD, Tumor necrosis factor receptor superfamily member 10D

Gen-ID: 8793

UniProt: Q9UBN6

Pathways: Apoptose