TNFRSF10B Antikörper (Extracellular Domain) (PE)

Produktnummer ABIN238402

Dieser Maus Monoklonal Antikörper detektiert spezifisch TNFRSF10B in FACS. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für TNFRSF10B Antikörper (Extracellular Domain) (PE) (ABIN238402)

Target: TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TNFRSF10B Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Klon: DR5-01-1

Produktdetails anti-TNFRSF10B Antikörper (PE)

Bindungsspezifität: Extracellular Domain

Spezifität: The antibody DR5-01-1 recognizes an extracellular domain of TRAIL-R2 (DR5). TRAIL-R2 is one of two TNF superfamily member intracellular death domain containing receptors for TRAIL (APO2L).

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Produktmerkmale: Synonyms: TNFRSF10B, DR5, KILLER, TRICK2, ZTNFR9, Death receptor 5, TRAIL receptor 2, TRAIL-R2,Tumor necrosis factor receptor superfamily member 10B, TNF-related apoptosis-inducingligand receptor 2

Aufreinigung: Size-Exclusion Chromatography.

Immunogen: Recombinant fusion protein of human IgG heavy chain and extracellular domain of DR5.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow Cytometry analysis: 5 μg/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS containing 15 mM Sodium Azide as preservative and 0.2 % (w/v) high-grade BSA (Protease free) as stabilizer.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody in the dark at 2-8 °C. DO NOT FREEZE! Avoid prolonged exposure to light.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu TNFRSF10B

Target: TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))

Andere Bezeichnung: CD262 / TRAILR2

Hintergrund: TRAIL-R2 (CD262, DR5) is one of two TNF superfamily member intracellular death domain containing receptors for TRAIL (APO2L). Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including tumor necrosis factor (TNF) and Fas ligand in the TNF family through their death domain containing receptors, TNF receptor 1 (TNFR1) and Fas, respectively. Another member in the TNF family has been identified and designated TRAIL (for TNF related apoptosis inducing ligand) and Apo2L (for Apo2 ligand). Receptors for TRAIL include two death domain containing receptors, DR4 and DR5, as well as two decoy receptors, DcR1 and DcR2, lacking the intracellular signaling death domain. DcR1 (also called TRID), like the related death receptors DR4 and DR5, contains two extracellular cysteine rich domains. However, DcR1 contains no intracellular death domain and is thus incapable of signaling apoptosis. It has been suggested DcR1 is responsible for TRAIL resistance in normal human tissues including heart, placenta, lung, liver, kidney, spleen, and bone marrow. DR5 is a member of the TNF receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor related apoptosis inducing ligand (TNFSF10/TRAIL/APO2L), and transduces apoptosis signal. Studies with FADD deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.Synonyms: DR5, Death receptor 5, KILLER, TNF-related apoptosis-inducing ligand receptor 2, TNFRSF10B, TRAIL receptor 2, TRAIL-R2, TRICK2, Tumor necrosis factor receptor superfamily member 10B, ZTNFR9

Gen-ID: 8795

UniProt: O14763

Pathways: p53 Signalweg, Apoptose, Positive Regulation of Endopeptidase Activity