CDKN2B Antikörper (Middle Region)

Produktnummer ABIN184173

Der Kaninchen Polyklonal anti-CDKN2B Antikörper (ABIN184173) detektiert spezifisch CDKN2B in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte, Hund, Schwein, Kaninchen und Meerschweinchen.

Kurzübersicht für CDKN2B Antikörper (Middle Region) (ABIN184173)

Target: CDKN2B (Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) (CDKN2B))

Reaktivität: Human, Maus, Ratte, Hund, Schwein, Kaninchen, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDKN2B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CDKN2B Antikörper

Bindungsspezifität: Middle Region

Sequenz: REGFLDTLVV LHRAGARLDV RDAWGRLPVD LAEERGHRDV AGYLRTATGD

Homologie: Dog: 91%, Guinea Pig: 83%, Mouse: 83%, Pig: 100%, Rabbit: 91%, Rat: 83%

Produktmerkmale: This is a rabbit polyclonal antibody against CDKN2B. It was validated on Western Blot using a cell lysate as a positive control.

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CDKN2B

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 138 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu CDKN2B

Target: CDKN2B (Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) (CDKN2B))

Andere Bezeichnung: CDKN2B

Hintergrund: CDKN2B's gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. CDKN2B is a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition.
Alias Symbols: P15, MTS2, TP15, CDK4I, INK4B, p15INK4b
Protein Interaction Partner: UBC, TRAF1, CDK6, CCDC33, NIF3L1, CDK4, PYCRL, RNF20, TGFB1I1, ISL1, APP, KIAA1377, CCDC90B, ARPC3, ZBTB17, IKBKAP, CDK8, MAGEA11, PIAS2,
Protein Size: 138

Molekulargewicht: 15 kDa

Gen-ID: 1030

NCBI Accession: NM_004936, NP_004927

UniProt: P42772

Pathways: Zellzyklus, Mitotic G1-G1/S Phases