CIITA Antikörper (C-Term)

Produktnummer ABIN183407

Der Kaninchen Polyklonal anti-CIITA Antikörper wird verwendet zum Nachweis von CIITA in Proben von Human, Maus, Ratte und Hund. Er wurde validiert für WB.

Kurzübersicht für CIITA Antikörper (C-Term) (ABIN183407)

Target: CIITA (Class II, Major Histocompatibility Complex, Transactivator (CIITA))

Reaktivität: Human, Maus, Ratte, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CIITA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CIITA Antikörper

Bindungsspezifität: C-Term

Sequenz: MALWESLQQQ GEAQLLQAAE EKFTIEPFKA KSPKDVEDLD RLVQTQRLRN

Homologie: Dog: 100%, Human: 79%, Mouse: 100%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against C2TA. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of mouse C2TA

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1078 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu CIITA

Target: CIITA (Class II, Major Histocompatibility Complex, Transactivator (CIITA))

Andere Bezeichnung: C2TA

Hintergrund: C2ta is essential for transcriptional activity of the HLA class II promoter, activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. C2ta may act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter
Alias Symbols: C2ta, Gm9475, EG669998
Protein Interaction Partner: Rfxank, Ssbp4, Ssbp3, Gmeb1, Cited4, Tcf3, Nfe2, Hoxa2, Ewsr1,
Protein Size: 1078

Molekulargewicht: 119 kDa

Gen-ID: 12265

NCBI Accession: NM_007575, NP_031601

UniProt: Q3U2P0

Pathways: Cancer Immune Checkpoints