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CREB1 Antikörper (N-Term)

CREB1 Reaktivität: Human, Maus, Ratte WB, IP, EIA, EMSA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN116948
  • Target Alle CREB1 Antikörper anzeigen
    CREB1 (cAMP Responsive Element Binding Protein 1 (CREB1))
    Bindungsspezifität
    • 67
    • 29
    • 20
    • 17
    • 16
    • 16
    • 10
    • 8
    • 8
    • 8
    • 8
    • 7
    • 7
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 292
    • 214
    • 180
    • 33
    • 24
    • 18
    • 17
    • 14
    • 12
    • 10
    • 9
    • 8
    • 8
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 265
    • 29
    • 1
    • 1
    Kaninchen
    Klonalität
    • 240
    • 56
    Polyklonal
    Konjugat
    • 149
    • 16
    • 14
    • 12
    • 12
    • 11
    • 11
    • 11
    • 11
    • 10
    • 10
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    Dieser CREB1 Antikörper ist unkonjugiert
    Applikation
    • 225
    • 100
    • 98
    • 74
    • 56
    • 56
    • 48
    • 47
    • 20
    • 17
    • 17
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunoprecipitation (IP), Enzyme Immunoassay (EIA), Electrophoretic Mobility-Shift Assay (EMSA)
    Spezifität
    This product was prepared from monospecific antiserum by delipidation and Immunoadsorption against an E.coli lysate immobilized on agarose beads. This antibody may react non-specifically with other proteins. A partial cross-reactivity is observed against CREM-1 protein.
    Immunogen
    CREB-1 (p43) peptide corresponding to a region near the N-terminus of the Human protein conjugated to Keyhole Limpet Hemocyanin (KLH).
    Top Product
    Discover our top product CREB1 Primärantikörper
  • Applikationshinweise
    Western Blot: This antibody was assayed against a lysate of 1 x 10^6 Raji B cells byImmunoblot and found to be reactive against CREB-1 (p43), showing a 46 kDa band at adilution of 1/500-1/1,000 followed by reaction with Peroxidase conjugated anti-Rabbit IgG(H&L) [Goat] (Cat#R1364HRP)ELISA: 1/5,000-1/25,000. Immunoprecipitation. Gelshift: This antibody was tested in Gel Supershift Assay and found to be reactive againstCREB-1 (p43) using 0.5-1.0 μL per assay.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    2.56 mg/mL (by UV absorbance at 280 nm)
    Buffer
    0.02 M Potassium Phosphate, 0.12 M Sodium Chloride, pH 7.2, 0.01 % (w/v) Sodium Azide, None
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store lyophilized (preferably in a desiccator) at 2-8 °C and reconstituted (in aliquots) at -20 °C.
  • Target
    CREB1 (cAMP Responsive Element Binding Protein 1 (CREB1))
    Andere Bezeichnung
    CREB1 (CREB1 Produkte)
    Synonyme
    creb antikoerper, CREB1 antikoerper, Creb1 antikoerper, CREB antikoerper, 2310001E10Rik antikoerper, 3526402H21Rik antikoerper, AV083133 antikoerper, Creb antikoerper, Creb-1 antikoerper, creb1 antikoerper, zgc:55598 antikoerper, cAMP responsive element binding protein 1 antikoerper, cAMP responsive element binding protein antikoerper, cAMP responsive element binding protein 1 S homeolog antikoerper, cAMP responsive element binding protein 1a antikoerper, CREB1 antikoerper, creb1 antikoerper, CREB antikoerper, Creb1 antikoerper, creb1.S antikoerper, creb1a antikoerper
    Hintergrund
    Cyclic AMP Response Element Binding protein (CREB) is a basic / leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Activation of CREB is dependent upon the phosphorylation of serine 133. Phosphorylation occurs via p44 / 42 MAP kinase and p90RSK and also via p38 MAP kinase and MSK 1. Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133. CREB appears to play an important role in learning and memory. CREB knock out mice show diminished learning ability.Synonyms: CREB-1, Cyclic AMP-responsive element-binding protein 1, cAMP-responsive element-binding protein 1
    Gen-ID
    1385
    NCBI Accession
    NP_004370
    UniProt
    P16220
    Pathways
    TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Thyroid Hormone Synthesis, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Regulation of Cell Size, Toll-Like Receptors Cascades, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Positive Regulation of fat Cell Differentiation
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