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Indoleamine 2,3-Dioxygenase 1 Proteine (IDO1)

Bezeichnung:
Indoleamine 2,3-Dioxygenase 1 Proteine (IDO1)
Auf www.antikoerper-online.de finden Sie aktuell 12 Indoleamine 2,3-Dioxygenase 1 (IDO1) Proteine von 6 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Indoleamine 2,3-Dioxygenase 1 Antikörper (176) und Indoleamine 2,3-Dioxygenase 1 Kits (15) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 214 Indoleamine 2,3-Dioxygenase 1 Produkte verfügbar.
Synonyme:
cd107b, Ido, IDO-1, IDO1, Indo
alle Proteine anzeigen Gen GeneID UniProt
IDO1 3620 P14902
IDO1 15930 P28776
IDO1 66029 Q9ERD9

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Am meisten referenzierte Indoleamine 2,3-Dioxygenase 1 Proteine

  1. Human IDO1 Protein expressed in Escherichia coli (E. coli) - ABIN2004475 : Barnes, Stephenson, Tooze, Doody: Amino acid deprivation links BLIMP-1 to the immunomodulatory enzyme indoleamine 2,3-dioxygenase. in Journal of immunology (Baltimore, Md. : 1950) 2009 (PubMed)

Weitere Proteine zu Indoleamine 2,3-Dioxygenase 1 Interaktionspartnern

Cow (Bovine) Indoleamine 2,3-Dioxygenase 1 (IDO1) Interaktionspartner

  1. Differential expression of CD25 (zeige IL2RA Proteine) and IDO mRNA with high and low virulence bovine viral diarrhea virus might reflect temporal differences in transcription during the immune response elicited by these viral strains.

  2. IDO may be involved in downregulating immune responses to M. avium subsp. paratuberculosis and other virulent mycobacteria, which may be an example of the pathogen harnessing host immunoregulatory pathways to aid survival.

  3. INDO participates in IFN-gama-induced death of bovine luteal cells, through a mechanism that involves degradation of tryptophan, thereby reducing tryptophan concentrations to a point insufficient to meet luteal cells needs

Rhesus Monkey Indoleamine 2,3-Dioxygenase 1 (IDO1) Interaktionspartner

  1. SIV-infected macaques exhibiting progression to AIDS displayed greater expression of TGF-beta (zeige TGFB1 Proteine) and indoleamine 2,3 dioxygenase in CD8 (zeige CD8A Proteine)+ T cells from mesentric lymph nodes.

Human Indoleamine 2,3-Dioxygenase 1 (IDO1) Interaktionspartner

  1. Together, these results suggest that RSV infection of MSCs alters their immune regulatory function by upregulating IFN-b and IDO, affecting immune cell proliferation, which may account for the lack of protective RSV immunity and for chronicity of RSV-associated lung diseases such as asthma and COPD (zeige ARCN1 Proteine).

  2. Thus, our study provides novel insights into the interaction between a small molecule inhibitor INCB14943 and IDO1 protein. The structural information will facilitate future IDO1 inhibitor design.

  3. The aim of the present study was to clarify the effect of IDO1induced macrophages on the growth of endometrial stromal cells in endometriosis. IDO1 educated-macrophages may facilitate the survival of retrograde endometrial tissues, and be involved in the pathogenesis of endometriosis.

  4. Our results identified FGL2 (zeige FGL2 Proteine), GAL (zeige GAL Proteine), SEMA4D (zeige SEMA4D Proteine), SEMA7A (zeige SEMA7A Proteine), and IDO1 as new candidate genes that could be involved in MSCs-mediated immunomodulation. FGL2 (zeige FGL2 Proteine), GAL (zeige GAL Proteine), SEMA4D (zeige SEMA4D Proteine), SEMA7A (zeige SEMA7A Proteine), and IDO1 genes appeared to be differentially transcribed in the different MSC (zeige MSC Proteine) populations. Moreover, these genes were not similarly modulated following MSCs-exposure to inflammatory signals

  5. IDO mediated conversion of FOXP3 (zeige FOXP3 Proteine) -T cells to Tregs predominantly occurs in children with inflammatory bowel disease.

  6. The study confirmed that high IDO expression in pancreatic adenocarcinoma was related to poor prognosis of patients. These findings provided evidence that IDO was involved in pancreatic adenocarcinoma progression and might serve as a relevant therapeutic target.

  7. ver-expression of CTLA4 (zeige CTLA4 Proteine) and IDO1 was significantly associated with biochemical recurrence. Our results provide clues on the mechanisms of tumor development and point to potential biomarkers for early detection and treatment for prostate cancer in young men.

  8. IDO1 mRNA expression in cervical cancer

  9. IDO gene expression is a feature of aggressive non-muscle-invasive urothelial cell bladder carcinoma, suggesting a potential immunosuppressive role of IDO

  10. Data show that in the absence of indoleamine 2,3-dioxygenase (IDO) inhibition, fatty acid oxidation increased along with increased activity of carnitine palmitoyltransferase I (CPT1 (zeige CPT1A Proteine)).

Mouse (Murine) Indoleamine 2,3-Dioxygenase 1 (IDO1) Interaktionspartner

  1. Across strains, networks depicted a predominance of genes under-expressed in microglia relative to macrophages that may be a precursor for the different response of both cell types to challenges. The detected transcriptome differences enhance the understanding of the role of IDO1 in the microglia transcriptome under unchallenged conditions.

  2. Data show that indoleamine 23-dioxygenase 1 (IDO-1) inhibitors 1-methyl-D-tryptophan was able to alleviate most of the behavioural changes resulting from unpredictable chronic mild stress (UCMS) exposure.

  3. IDO did not play a pivotal role in the suppression of allergic airway inflammation through adipose-derived stem cells, suggesting that it is not the major regulator responsible for suppressing allergic airway inflammation.

  4. These results indicate that Platelet-activating Factor -mediated endotoxin tolerance is initiated via IDO- and JAK (zeige JAK3 Proteine)/STAT (zeige STAT1 Proteine)-dependent expression of SOCS3 (zeige SOCS3 Proteine).

  5. Aortic Plasmacytoid dendritic cells expressed CCR9 (zeige CCR9 Proteine) and indoleamine 2,3-dioxygenase 1 (IDO-1), an enzyme involved in driving the generation of regulatory T cells (Tregs).

  6. Indoleamine-2,3-dioxygenase (IDO) production by Plasmacytoid dendritic cells (pDCs)is necessary to confer suppressive function to T-Cells, Regulatory (Tregs) in experimental autoimmune encephalomyelitis (EAE).

  7. our findings support the hypothesis elevated IDO activity in non-CNS due to virus infections causes pain hypersensitivity

  8. this study shows that IDO overexpression in dendritic cells attenuates acute allograft rejection

  9. This insight into IDO1's involvement in pro-tumorigenic inflammatory neovascularization may have important ramifications for IDO1 inhibitor development, not only in cancer where clinical trials are currently ongoing, but in other disease indications associated with neovascularization as well.

  10. Inhibition of IDO activity ameliorated Japanese encephalitis via enhancement of antiviral IFN-I/II innate and adaptive T-cell responses and increased central nervous system infiltration of peripheral leukocytes.

Pig (Porcine) Indoleamine 2,3-Dioxygenase 1 (IDO1) Interaktionspartner

Indoleamine 2,3-Dioxygenase 1 (IDO1) Protein Überblick

Protein Überblick

This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.

Alternative names and synonyms associated with Indoleamine 2,3-Dioxygenase 1 (IDO1)

  • indoleamine 2,3-dioxygenase 1 (IDO1)
  • indoleamine 2,3-dioxygenase 1 (ido1)
  • indoleamine 2,3-dioxygenase 1 (Ido1)
  • indoleamine 2,3-dioxygenase 1-like (LOC100050681)
  • cd107b Protein
  • Ido Protein
  • IDO-1 Protein
  • IDO1 Protein
  • Indo Protein

Bezeichner auf Proteinebene für IDO1

indoleamine-pyrrole 2,3 dioxygenase , indoleamine 2,3-dioxygenase 2 , proto-IDO , putative indoleamine 2,3-dioxygenase , indoleamine 2,3-dioxygenase 1 , indolamine 2,3 dioxygenase , indole 2,3-dioxygenase , indoleamine-pyrrole 2,3-dioxygenase , IDO-1 , indoleamine 23-dioxygenase

GENE ID SPEZIES
506281 Bos taurus
100037099 Xenopus laevis
100086385 Ornithorhynchus anatinus
448488 Xenopus (Silurana) tropicalis
464134 Pan troglodytes
571967 Danio rerio
574370 Macaca mulatta
100032999 Monodelphis domestica
100196903 Ovis aries
3620 Homo sapiens
15930 Mus musculus
66029 Rattus norvegicus
475574 Canis lupus familiaris
100519877 Sus scrofa
100050681 Equus caballus
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