anti-FOXO3 (FOXO3) Antikörper

Human Forkhead Box O3 (FOXO3) Interaktionspartner

1. cigarette smoke extract (CSE) impairs the function of SIRT1/FoxO3 axis in bronchial epithelium, dysregulating NF-kappaB activity and inducing pro-inflammatory responses

2. NOVA1 acted as an oncogene in the development of melanoma partly through regulating FoxO3A expression.

3. miR-182-5p directly targets 3'-UTR of FOXO3a and repressed FOXO3a expression, activating AKT/FOXO3a pathway to promote hepatocellular carcinoma proliferation.

4. Aberrant expression of miR-9 blocks erythropoiesis by deregulating FoxO3-mediated pathways.

5. miR-182 was a positive regulator of interferon regulatory factor 7 (IRF7) by directly targeting FOXO3, resulting in the induction of IFN-I response and suppression of human cytomegalovirus (HCMV) replication in neural cells.

6. The FOXO3 are critical regulators of Intervertebral disk (IVD) homeostasis during aging and suggest that maintaining or restoring FOXO3 expression can be a therapeutic strategy to promote healthy IVD aging and delay the onset of IVD degeneration.

7. Using data from four longevity studies (total n = 8,266, age range 96-119 years for cases), we tested gene-wide association between 107 SNPs and survival to at least the oldest 1 percentile of survival for the 1900 birth cohort. An uncommon homozygote genotype of rs9384680 exhibited the strongest association with mortality risk (p = 2.68E-04) in only 11 females, a heretofore unreported association.

8. We found that telomere length for carriers of the longevity associated allele of FOXO3 single nucleotide polymorphism rs2802292 displayed no significant correlation with age. This is the first validated longevity gene variant identified to date showing an association with negligible loss of telomere length with age in humans.

9. Mitochondrial FoxO3A promotes cancer cell survival in response to metabolic stress.

10. None of the 4 FOXO3 variants, rs13217795, rs2764264, rs2802292, and rs13220810, were associated with the risk of type 2 diabetes compared to controls. rs13217795, rs2764264, and rs2802292 were associated with lower blood glucose levels. further subgroup analysis indicated that the longevity-associated alleles of FOXO3 SNP (rs13217795, rs2764264, and rs2802292) were associated with lower blood glucose levels in women.

11. these results suggest that miR-590-3p promotes ovarian cancer development, in part by directly targeting CCNG2 and FOXO3.

12. overexpression of FOXO3a in ovarian cancer inversed the platinum resistance in ovarian cancer. the role of FOXO3a might be one of the critical mechanisms in developing platinum drug resistance in ovarian cancer.

13. we demonstrated that overexpression of CHP2 enhanced G1-S phase transition mediated by AKT activation, which subsequently induced phosphorylation and inactivation of FOXO3a in breast cancer cells.

14. A 90-bp sequence around the intronic single nucleotide polymorphism rs2802292 has enhancer functions, and that the rs2802292 G-allele creates a novel HSE binding site for HSF1, which induces FOXO3 expression in response to diverse stress stimuli.

15. High expression of FOXO3 is associated with pancreatic cancer.

16. miR1225p inhibited apoptosis and facilitated tumor progression by targeting FOXO3 in alphafetoproteinproducing gastric cancer.

17. Low FOXO3 expression is associated with epithelial-mesenchymal transition and metastasis of pancreatic ductal adenocarcinoma.

18. FOXO3A levels in cHL were found higher than in germinal center B cells, but lower than in terminally differentiated PCs. This intermediate FOXO3A expression in classical Hodgkin lymphoma might manifest the "abortive PC differentiation" phenotype.

19. FOXO3 exhibited promotive effects on the proliferation and doxorubicin resistance in colon cancercells via targeting MDR1.

20. the loss of FOXO3-mediated immune landscape, pathways, and transcripts that could serve as biomarkers and new targets for inflammatory colon cancer treatment, were identified.

Pig (Porcine) Forkhead Box O3 (FOXO3) Interaktionspartner

1. AIM1 and FOXO3 genes were found to be associated with NBA (number born alive); these genes increase ovarian reproductive capacity and follicle number and decrease gonadotropin levels.

2. These results indicate that myostatin mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 and glucocorticoid receptor binding to its promoter.

3. In granulosa cells, cell death is induced by transfection of FOXO3. FOXO3 mRNA in granulosa cells increases during atresia; FOXO3 protein is abundant in granulosa cells of early atretic follicles. (FOXO3 AA sequence homology with human/mouse FOXO3)

4. PTEN, FOXO3A and PKB were expressed in a stage- and cell-specific manner during ovarian follicle formation and development in the fetal and neonatal pig.

5. Primordial oocytes are dormant in prepubertal pigs by a FOXO3-related mechanism to establish a nongrowing oocyte pool in the ovary, and that a transient knockdown of the FOXO3 activates the primordial oocytes to enter the growth phase.

6. FoxO3a was localized in the granulosa cells of follicles at all stages and was extensively localized in the cytoplasma of the luteinized granulosa cells of corpora lutea

Zebrafish Forkhead Box O3 (FOXO3) Interaktionspartner

1. by modulating hypoxia-inducible factor activity via up-regulation of VHL, FOXO3a (foxo3b) plays an important role in survival in response to hypoxic stress.

2. This study provided novel evidence of FoxO3a in the embryonic neurodevelopment from zebrafish to other mammals.

Mouse (Murine) Forkhead Box O3 (FOXO3) Interaktionspartner

1. FoxO3a transcription factor regulates PHLPP1 expression in chondrocytes.

2. The FOXO3 are critical regulators of Intervertebral disk (IVD) homeostasis during aging and suggest that maintaining or restoring FOXO3 expression can be a therapeutic strategy to promote healthy IVD aging and delay the onset of IVD degeneration.

3. A TLR/AKT/FoxO3 immune tolerance-like pathway disrupts the repair capacity of oligodendrocyte progenitors.

4. GCN2 deficiency protects mice from denervation-induced skeletal muscle atrophy via inhibiting FoxO3a nuclear translocation

5. ZEB1/CtBP and FOXO3 have opposing transcriptional activities and regulate muscle atrophy-related genes

6. May survive inappropriately in the absence of Foxo3.

7. results demonstrate that Sirt1 overexpression in MSCs increased the osteoblastic bone formation and partially restores the defects in skeletal growth and osteogenesis in Bmi-1(-/-) mice by FOXO3a deacetylation and oxidative stress inhibition

8. FOXO3 directly binds a network of target genes in adult neural stem and progenitor cells (NSPCs) that are involved in autophagy, and we find that FOXO3 functionally regulates induction of autophagy in these cells. Interestingly, in the absence of FOXO activity, protein aggregates accumulate in NSPCs.

9. the loss of FOXO3-mediated immune landscape, pathways, and transcripts that could serve as biomarkers and new targets for inflammatory colon cancer treatment, were identified.

10. expression in lumbar intervertebral discs decreased with aging

11. Foxo3a translocation was not driven by AbetaPP intracellular domain directly but correlated with reduced Akt phosphorylation. betagamma-secretase-mediated AbetaPP processing couples to Foxo3a which could be an early neuronal signaling response in Alzheimer's disease.

12. Foxo3a physically interacts with Tet2 and regulates the expression of genes related to adult neural stem cells proliferation.

13. FOXO transcription factors play a salutary role in the protection against the diet-induced fatty liver disease.

14. data suggested that suppressed Sirt3-Foxo3A-Parkin signaling mediated downregulation of mitophagy may play a vital role in the development of diabetic cardiomyopathy.

15. AMPK stabilizes FOXO3 and suggest a role in the first initiation step of mitochondrial segregation in muscle cells.

16. Data indicate a key role of FoxO3a/Zdhhc3/GluA1 axis in the high-fat diet (HFD)-dependent impairment of cognitive function.

17. Taken together, these data implicate Foxo3 and its transcriptional targets in outer hair cell survival after noise damage.

18. These results reveal mechanisms by which FoxO3a promotes host survival during infection with chronic, virulent intracellular bacteria.

19. findings demonstrate that the mTORC2/AKT/FOXO3a axis plays a critical role in the anti-proliferative and pro-apoptotic effects of lycopene in UVB-induced photocarcinogenesis.

20. The results indicate that increased circulating GH is associated with a reduced ovarian primordial follicle reserve and increased pFoxO3a content in oocytes.

Cow (Bovine) Forkhead Box O3 (FOXO3) Interaktionspartner

1. NO/protein kinase G (PKG)-dependent downregulation of PGC-1 alpha and the ROS detoxification system in endothelial cells are mediated by the PI3K/Akt signaling pathway and subsequent inactivation of transcription factor Foxo3a.

2. FOXO is a key regulator of ROS-induced apoptosis in mammalian cells.

Rhesus Monkey Forkhead Box O3 (FOXO3) Interaktionspartner

1. FOXO1, 3, and 4 as well as their upstream regulator, AKT/p-AKT, was examined in rhesus macaque ovaries of three developmental stages: fetal, prepubertal, and adult