anti-FOXO3 (FOXO3) Antikörper

Human Forkhead Box O3 (FOXO3) Interaktionspartner

1. Low FOXO3 expression is associated with epithelial-mesenchymal transition and metastasis of pancreatic ductal adenocarcinoma.

2. FOXO3A levels in cHL were found higher than in germinal center B cells, but lower than in terminally differentiated PCs. This intermediate FOXO3A expression in classical Hodgkin lymphoma might manifest the "abortive PC differentiation" phenotype.

3. FOXO3 exhibited promotive effects on the proliferation and doxorubicin resistance in colon cancercells via targeting MDR1.

4. the loss of FOXO3-mediated immune landscape, pathways, and transcripts that could serve as biomarkers and new targets for inflammatory colon cancer treatment, were identified.

5. The present results indicate that miR122 serves a tumorpromoting role by direct targeting FOXO3 in clear cell renal cell carcinoma.

6. Longevity-associated FOXO3 variants may be associated with lower blood pressure and essential hypertension in Japanese women.

7. Emerging evidences indicate that FOXO3a acts as a tumor suppressor in cancer. FOXO3a is frequently inactivated in cancer cell lines by mutation of the FOXO3a gene or cytoplasmic sequestration of FOXO3a protein. And its inactivation is associated with the initiation and progression of cancer. [review]

8. In liver cancer cell lines, inhibition the activity of PI3K/Akt signaling pathway significantly decreased the levels of phosphorylated FOXO3a and increased the total levels of FOXO3a, which was accompanied by the accumulation of nuclear FOXO3a. Moreover, cell proliferation of liver cancer cells was significantly suppressed by inhibition the PI3K/Akt/FOXO3a signaling pathway.

9. Mechanistically, authors found miR-10b-3p regulated FOXO3 expression by directly binding to the 3'-untranslated region.

10. The significant association between forkhead box protein O3 (FOXO3) single nucleotide polymorphisms (SNPs) and longevity has been independently replicated in multiple populations including a genome-wide association study [Review].

11. Acetylated FOXO3a recognizes the BD2 domain of BRD4, recruits the BRD4/RNAPII complex to the CDK6 gene promoter, and induces its transcription.

12. expression significantly deceased in degenerated discs

13. Loss of FOXO3 expression due to O-GlcNAcylation is associated with tumorigenesis.

14. This study revealed a novel mechanism for prostate cancer metastasis that involves SIRT3/ Wnt/beta-catenin/ FOXO3A signaling to modulate EMT and cell migration.

15. Study findings present a novel mechanism that controls FOXO3 activation and revealed that SIRT6 is a pivotal regulatory factor in determining liver cancer chemosensitivity. SIRT6 interacts with FOXO3 and this interaction increases FOXO3 ubiquitination and decreases its stability.

16. FOXO3a activation induces vascular smooth muscle cell apoptosis and extracellular matrix breakdown, in part, because of transcriptional activation of MMP13. FOXO3a activation promotes atherosclerosis and medial degeneration and increases neointima after injury that is partly dependent on MMP13.

17. The finding suggested that miR-30c-5p might play essential role in NLRP3 inflammasome-modulated cell pyroptosis by targeting FOXO3 in human aortic endothelial cells.

18. The cardiac regeneration may be promoted by proper control of FOXO1/3 activity. FOXO1 mainly plays a detrimental role in heart while FOXO3's actions are influenced by cell type. [review]

19. role in autophagy activation and the maintenance of intracellular homeostasis in inflamed odontoblasts

20. Low FOXO3A expression is associated with colorectal cancer.

Pig (Porcine) Forkhead Box O3 (FOXO3) Interaktionspartner

1. AIM1 and FOXO3 genes were found to be associated with NBA (number born alive); these genes increase ovarian reproductive capacity and follicle number and decrease gonadotropin levels.

2. These results indicate that myostatin mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 and glucocorticoid receptor binding to its promoter.

3. In granulosa cells, cell death is induced by transfection of FOXO3. FOXO3 mRNA in granulosa cells increases during atresia; FOXO3 protein is abundant in granulosa cells of early atretic follicles. (FOXO3 AA sequence homology with human/mouse FOXO3)

4. PTEN, FOXO3A and PKB were expressed in a stage- and cell-specific manner during ovarian follicle formation and development in the fetal and neonatal pig.

5. Primordial oocytes are dormant in prepubertal pigs by a FOXO3-related mechanism to establish a nongrowing oocyte pool in the ovary, and that a transient knockdown of the FOXO3 activates the primordial oocytes to enter the growth phase.

6. FoxO3a was localized in the granulosa cells of follicles at all stages and was extensively localized in the cytoplasma of the luteinized granulosa cells of corpora lutea

Zebrafish Forkhead Box O3 (FOXO3) Interaktionspartner

1. by modulating hypoxia-inducible factor activity via up-regulation of VHL, FOXO3a (foxo3b) plays an important role in survival in response to hypoxic stress.

2. This study provided novel evidence of FoxO3a in the embryonic neurodevelopment from zebrafish to other mammals.

Mouse (Murine) Forkhead Box O3 (FOXO3) Interaktionspartner

1. results demonstrate that Sirt1 overexpression in MSCs increased the osteoblastic bone formation and partially restores the defects in skeletal growth and osteogenesis in Bmi-1(-/-) mice by FOXO3a deacetylation and oxidative stress inhibition

2. FOXO3 directly binds a network of target genes in adult neural stem and progenitor cells (NSPCs) that are involved in autophagy, and we find that FOXO3 functionally regulates induction of autophagy in these cells. Interestingly, in the absence of FOXO activity, protein aggregates accumulate in NSPCs.

3. the loss of FOXO3-mediated immune landscape, pathways, and transcripts that could serve as biomarkers and new targets for inflammatory colon cancer treatment, were identified.

4. expression in lumbar intervertebral discs decreased with aging

5. Foxo3a translocation was not driven by AbetaPP intracellular domain directly but correlated with reduced Akt phosphorylation. betagamma-secretase-mediated AbetaPP processing couples to Foxo3a which could be an early neuronal signaling response in Alzheimer's disease.

6. Foxo3a physically interacts with Tet2 and regulates the expression of genes related to adult neural stem cells proliferation.

7. FOXO transcription factors play a salutary role in the protection against the diet-induced fatty liver disease.

8. data suggested that suppressed Sirt3-Foxo3A-Parkin signaling mediated downregulation of mitophagy may play a vital role in the development of diabetic cardiomyopathy.

9. AMPK stabilizes FOXO3 and suggest a role in the first initiation step of mitochondrial segregation in muscle cells.

10. Data indicate a key role of FoxO3a/Zdhhc3/GluA1 axis in the high-fat diet (HFD)-dependent impairment of cognitive function.

11. Taken together, these data implicate Foxo3 and its transcriptional targets in outer hair cell survival after noise damage.

12. These results reveal mechanisms by which FoxO3a promotes host survival during infection with chronic, virulent intracellular bacteria.

13. findings demonstrate that the mTORC2/AKT/FOXO3a axis plays a critical role in the anti-proliferative and pro-apoptotic effects of lycopene in UVB-induced photocarcinogenesis.

14. The results indicate that increased circulating GH is associated with a reduced ovarian primordial follicle reserve and increased pFoxO3a content in oocytes.

15. Melanoma dormancy in a mouse model is linked to GILZ/FOXO3A-dependent quiescence of disseminated stem-like cells

16. data showed that Klotho protects Tac-induced oxidative stress by negatively regulating the PI3K/AKT pathway and subsequently enhancing FoxO3a-mediated MnSOD expression.

17. miR-34a might suppress the excessive autophagic activity in alveolar type II epithelial AT-II cells via targeting FoxO3 to reduce the damage of LPS-induced Acute Lung Injury.

18. PPE effectively attenuated oxidative stress and ototoxicity by regulating FoxO3a, and may thus prove to be beneficial in protecting auditory cells from ototoxic drugs.

19. Results show that Foxo3a is depressed in the nucleus while autophagy is impaired, and NLRP3 inflammasome is activated in Kupffer cells (KCs). Over-expression of Foxo3a restores autophagy flux and attenuates activation of the NLRP3 inflammasome via promoting the transcription of Bim.

20. Data indicate that forkhead box O3 (FoxO3) has a central role in the neuronal reprogramming susceptibility of cells, and the importance of FoxO3 appears to change during development.

Cow (Bovine) Forkhead Box O3 (FOXO3) Interaktionspartner

1. NO/protein kinase G (PKG)-dependent downregulation of PGC-1 alpha and the ROS detoxification system in endothelial cells are mediated by the PI3K/Akt signaling pathway and subsequent inactivation of transcription factor Foxo3a.

2. FOXO is a key regulator of ROS-induced apoptosis in mammalian cells.

Rhesus Monkey Forkhead Box O3 (FOXO3) Interaktionspartner

1. FOXO1, 3, and 4 as well as their upstream regulator, AKT/p-AKT, was examined in rhesus macaque ovaries of three developmental stages: fetal, prepubertal, and adult