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anti-Mouse (Murine) COPS5 Antikörper:
anti-Human COPS5 Antikörper:
anti-Rat (Rattus) COPS5 Antikörper:
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Fruit Fly (Drosophila melanogaster) Monoclonal COPS5 Primary Antibody für ICC, IF - ABIN267291
Gemmill, Bemis, Lee, Sozen, Baron, Zeng, Erickson, Hooper, Drabkin: The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway. in Oncogene 2002
Show all 8 Pubmed References
Fruit Fly (Drosophila melanogaster) Monoclonal COPS5 Primary Antibody für IP, WB - ABIN152354
Doronkin, Djagaeva, Beckendorf: The COP9 signalosome promotes degradation of Cyclin E during early Drosophila oogenesis. in Developmental cell 2003
Show all 4 Pubmed References
COP9 (zeige COPS8 Antikörper) signalosome subunits 4 and 5 regulate multiple pleiotropic pathways in Drosophila melanogaster.
during oogenesis CSN5/JAB1, one subunit of the CSN, is required for meiotic progression and for establishment of both the AP and DV axes of the Drosophila oocyte
we link the CSN to the degradation of Cyclin E, which promotes the G1-S transition in the cell cycle and then is rapidly degraded by the ubiquitin-proteasome pathway
results presented here indicate that CSN5 is a negative regulator of Dorsal subcellular localization, and of hemocyte proliferation and differentiation
Genetic deletion of Csn5 in Apoe (zeige APOE Antikörper)(-/-) mice markedly exacerbated atherosclerotic lesion formation.
CSN3 (zeige CSN3 Antikörper) and CSN5 are involved in oocyte meiosis by regulating degradation of Cyclin B1 (zeige CCNB1 Antikörper) and Securin (zeige PTTG1 Antikörper) via APC (zeige APC Antikörper)/C.
COPS5 overexpression reduced spinophilin (zeige PPP1R9B Antikörper) in both the cortex (19%, p < 0.05) and the hippocampus (20%, p < 0.05), leading to significant deficits in learning and memory skills
Jab1 is an essential regulator of early embryonic limb development.
Lack of COPS5 in regenerating livers causes substantial replicative stress which triggers a cyclin-dependent kinase (zeige CDK1 Antikörper) inhibitor(CDKN)2A genetic program leading to cell cycle arrest, polyploidy, and apoptosis.
Jab1 may transduce laminin211 signals to regulate Schwann cell number and differentiation during axonal sorting.
Study demonstrates that Jab1 represses chondrocyte hypertrophy in vivo, likely in part by downregulating BMP signaling and Runx2 (zeige RUNX2 Antikörper) activity.
Data indicate that in Cul4b (zeige CUL4B Antikörper)-deficient embryonic fibroblasts showed Jab1 accumulation.
CSN5 functions through CDK2 (zeige CDK2 Antikörper) to control premature senescence in a novel way, depending on cyclin E (zeige CCNE1 Antikörper) in the cytoplasm.
It was shown that disruption of CSN5 prevented the formation of tumors by p53 (zeige TP53 Antikörper)-null cells that were transformed with an active form of Ras in subcutaneously injected mice. Depletion of CSN5 suppressed cell proliferation, and induced premature senescence.
BCL-G interacts with JAB1 in swine, revealing a molecular model for apoptosis
The porcine JAB1 gene was cloned and characterized.
We identified a novel Jab1-Trx (zeige VAC14 Antikörper) axis that is a key cellular process in the pathobiologic characteristics of acute myeloid leukemia (zeige BCL11A Antikörper) (AML (zeige RUNX1 Antikörper)-M5). Targeting the ROS (zeige ROS1 Antikörper)/Jab1/Trx (zeige VAC14 Antikörper) pathway could be beneficial in the treatment of AML (zeige RUNX1 Antikörper)-M5
These data identified CSN5 as a critical oncoprotein involved in progression of hepatocellular carcinoma (HCC (zeige FAM126A Antikörper)) cells, which could serve as a potential therapeutic target in HCC (zeige FAM126A Antikörper) patients.
The authors find that UCHL3 (zeige Uchl3 Antikörper) regulates COPS5-dependent deneddylation of Cullin1, which is an essential component of SCF (zeige KITLG Antikörper)(beta-TrCP (zeige BTRC Antikörper)) complex and associated with SCF (zeige KITLG Antikörper)(beta-TrCP (zeige BTRC Antikörper)) activities. The authors further demonstrate that UCHL3 (zeige Uchl3 Antikörper) upregulates the levels of SCF (zeige KITLG Antikörper)(beta-TrCP (zeige BTRC Antikörper)) substrates including IFN-I receptor IFNAR1 (zeige IFNAR1 Antikörper), which enhances IFN-I mediated signaling pathway and antiviral activity.
Collectively, our findings suggest that JAB1 activates the neuronal differentiation ability of CPNE1 (zeige CPNE1 Antikörper) through the binding of C2A domain in CPNE1 (zeige CPNE1 Antikörper) with MPN (zeige PRSS27 Antikörper) domain in JAB1.
data suggests that Jab1-mediated phosphorylation of p53 (zeige TP53 Antikörper) at Thr155 residue mediates nuclear export of p53 (zeige TP53 Antikörper)
CSN5 is contributed to colorectal cancer development by actively driving aberrant WNT (zeige WNT2 Antikörper) signaling through repression of the WNT (zeige WNT2 Antikörper) antagonist DKK1 (zeige DKK1 Antikörper).
The results of this study suggest that Jab1 promotes glioma cell proliferation and increased expression of Jab1 in glioma patients may amplify beta-catenin (zeige CTNNB1 Antikörper) signaling to contribute to glioma cell proliferation.
Furthermore, inhibition of COPS5 resulted in an elevation of Akt (zeige AKT1 Antikörper) expression and sensitized SOC (zeige UBXN11 Antikörper) cells to Akt (zeige AKT1 Antikörper) inhibitor MK2206. Suppression of COPS5 and Akt (zeige AKT1 Antikörper) offers a potential strategy for the treatment of SOC (zeige UBXN11 Antikörper).
The data identified CSN5 as a critical oncoprotein involved in migration and invasion of RCC (zeige XRCC1 Antikörper) cells, which could serve as a potential therapeutic target in RCC (zeige XRCC1 Antikörper) patients.
High JAB1 expression is associated with nasopharyngeal cancer.
The work described here supports a previously unknown role for the CSN/COP9 (zeige COPS8 Antikörper) signalosome in chromosome behavior during meiotic prophase I.
Data show that CSN-5 functions in muscle cells to regulate UNC-98 and -96, two M-line proteins.
KGB-1 and CSN-5 regulate GLH-1 levels, with GLH-1 targeted for proteosomal degradation by KGB-1 and stabilized by CSN-5.
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors.
, COP9 complex subunit 5
, JUN activation domain-binding protein-1
, Jun activation domain binding protein
, drosophila COP9 signalosome homolog 5
, COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)
, COP9 signalosome complex subunit 5
, signalosome subunit 5
, COP9 signalosome subunit 5
, COP9 signalosome complex subunit 5-like
, COP9 complex S5
, Jun activation domain-binding protein 1
, Jun coactivator
, Kip1 C-terminus-interacting protein 2
, COP9 constitutive photomorphogenic-like subunit 5
, c-Jun activation domain binding protein-1
, 38 kDa Mov34 homolog
, COP9 constitutive photomorphogenic homolog subunit 5
, jun activation domain-binding protein 1
, COP9 (constitutive photomorphogenic) homolog, subunit 5