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Overall, the authors find that p27 (zeige PAK2 ELISA Kits) directly promotes cell invasion by facilitating invadopodia turnover via the Rac1/PAK1 (zeige PAK1 ELISA Kits)/Cortactin (zeige CTTN ELISA Kits) pathway.
Upon binding to p27(Kip1) 3'UTR (zeige UTS2R ELISA Kits), CPEB1 (zeige CPEB1 ELISA Kits) promotes elongation of poly-A tail and the subsequent translation of p27(Kip1) mRNA. This leads to higher levels of p27(Kip1) in the cell, in turn significantly inhibiting cell proliferation, and confers to CPEB1 a potential value as a tumor suppressor in Glioblastoma.
some cancer cells are defective for efficient interaction between p27 (zeige PAK2 ELISA Kits) and CycA (zeige CCNA2 ELISA Kits)-CDK (zeige CDK4 ELISA Kits) complex due to qualitative alteration(s)
p27(kip1) overexpression regulates IL-1beta (zeige IL1B ELISA Kits) in the microenvironment of stem cells and eutopic endometriosis
Data suggest that NOX5 (zeige NOX5 ELISA Kits) expression in melanoma cells could contribute to cell proliferation due, in part, to the generation of high local concentrations of extracellular ROS (zeige ROS1 ELISA Kits) that modulate multiple pathways that regulate HIF-1alpha (zeige HIF1A ELISA Kits) and networks that signal through Akt (zeige AKT1 ELISA Kits)/GSK3beta (zeige GSK3b ELISA Kits)/p27(Kip1) .
SNHG6 acted as an oncogene (zeige RAB1A ELISA Kits) in gastric cancer cells through regulating miR (zeige MLXIP ELISA Kits)-101-3p/ZEB1 (zeige ZEB1 ELISA Kits) at a post-transcriptional level and silencing expression at a transcriptional level by recruiting enhancer of zeste homolog 2 (EZH2 (zeige EZH2 ELISA Kits)) to the promoter of p27 (zeige PAK2 ELISA Kits).
PCTAIRE1 (zeige CDK16 ELISA Kits) has a role in regulating p27 (zeige PAK2 ELISA Kits), c-Myc (zeige MYC ELISA Kits) levels and tumor growth in cutaneous cutaneous squamous cell carcinoma cells
Low P27KIP1 expression is associated with Non Small Cell Lung Cancer.
Results show that that Id2 was directly upregulated by BMP4 (zeige BMP4 ELISA Kits), resulting in the mediated expression of cell cycle regulatory protein of CDKN1B.
p27 (zeige PAK2 ELISA Kits) and its cognate ubiquitin ligases, Skp2/KPC/Pirh2 (zeige RCHY1 ELISA Kits), are specifically involved in determining the clinical profiles of lung carcinomas.
p27Kip1 inhibition has an effect on proliferation of bovine corneal endothelial cells by RNA interferenc
FoxO1a (zeige FOXO1 ELISA Kits) can regulate p27kip nuclear localization
the activation of Rac1 due to the cell-cell contact plays a critical role in the transcriptional up-regulation of p27Kip1 in vascular endothelial cells.
Our results revealed that CKS1 (zeige CKS1B ELISA Kits) is involved in normal glutamatergic synapse development and dendritic spine maturation in adult hippocampus through modulating p27 stability.
p27kip1 is involved in the decisive step around cell-cycle exit and plays an important role in activity-regulated and functionally relevant adult hippocampal neurogenesis.
p27(Kip1)-target genes are involved in cell adhesion and cell signaling in mouse embryonic fibroblasts.
This study demonstrates that LMP2A uses the role of MYC (zeige MYC ELISA Kits) in the cell cycle, particularly in the p27(kip1) degradation process, to accelerate lymphomagenesis in vivo.
Study reports that p27 normally exerts a negative feedback on p21 expression: p27 directly represses the expression of the transcription factor Pitx2 (zeige PITX2 ELISA Kits) which in turn maintains decreased p21 levels. Consequently, in cells lacking p27, de-repression of Pitx2 (zeige PITX2 ELISA Kits) causes the up-regulation of p21 showing a new mechanism by which p27 regulates cell cycle progression by transcriptionally regulating the expression of Pitx2 (zeige PITX2 ELISA Kits) and p21.
Fbxo7 (zeige FBXO7 ELISA Kits)-deficient immature thymocytes failed to undergo expansion in the thymus due to a lack of Cdk6 (zeige CDK6 ELISA Kits) activity, while mature T cells showed enhanced proliferative capacity upon T-cell receptor engagement due to reduced p27 levels. These studies reveal differential cell cycle regulation by Fbxo7 (zeige FBXO7 ELISA Kits) at different stages in T-cell development.
systems-level control of cell cycle arrest by pRB (zeige PGR ELISA Kits)-E2F (zeige E2F1 ELISA Kits) and p27-CDK (zeige CDK4 ELISA Kits) regulation, is reported.
Results demonstrated that the addition of oncogenic mutations, such as loss of p27 or p53 (zeige TP53 ELISA Kits), promotes ovarian tumor development from the benign adenomas of germ cell-deficient (zeige FANCL ELISA Kits) ovaries.
p27 inactivation promotes injury islet graft loss via the elevation of proliferation and inflammatory cytokines secretion in infiltrating macrophages which induced nonspecific inflammation independent of TNF-alpha (zeige TNF ELISA Kits)/nuclear factor-kappa b pathway. T
Knockout of p27 enhances arterial collateralization in response to hindlimb ischemia through enlargement of a new collateral pathway.
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.
cyclin-dependent kinase inhibitor 1B
, cyclin-dependent kinase inhibitor 1b (p27, kip1)
, cyclin-dependent kinase inhibitor 1B (p27, Kip1)
, cyclin-dependent kinase inhibitor p27
, Cyclin-dependent kinase inhibitor 1B (p27 Kip1)
, Cyclin-dependent kinase inhibitor 1B (p27, Kip1)
, cyclin-dependent kinase inhibitor p27/Kip1
, Cyclin-dependent kinase inhibitor p27
, cyclin-dependent kinase inhibitor 1b, like