anti-CDKN1B (CDKN1B) Antikörper

Human Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) Interaktionspartner

1. FLT3 (zeige FLT3 Antikörper) and FLT3 (zeige FLT3 Antikörper)-ITD can directly bind and selectively phosphorylate p27kip1 on tyrosine residue 88 in acute myeloid leukemia (zeige BCL11A Antikörper). Inhibition of FLT3 (zeige FLT3 Antikörper)-ITD in cell lines strongly reduced p27 (zeige PAK2 Antikörper) tyrosine 88 phosphorylation and resulted in increased p27 (zeige PAK2 Antikörper) levels and cell cycle arrest

2. Our results suggest that oxidised photoreceptor outer segments -induced retinal pigment epithelial cell cytokinesis failure is, at least in part, due to the upregulation of p27kip1 through activating the PKC (zeige PRRT2 Antikörper), particularly PKCzeta (zeige PRKCZ Antikörper) pathway

3. p27Kip1-838C>A; rs36228499 is functional in human venous smooth muscle cells (SMCs) and in adventitial cells. The AA genotype is associated with stronger expression of the p27 (zeige PAK2 Antikörper) gene and p27 (zeige PAK2 Antikörper) protein. Only the adventitial cells, and not the SMCs, are responsive to the inhibitory effects of the protective AA genotype in cell growth.

4. Overview of CDKN1B mutations in MEN4 (review)

5. Expression of CIP/KIP (zeige CIB1 Antikörper) proteins was found abundantly within the proliferative hair matrix, concomitant with a role in cell cycle checkpoint control. p21(CIP1 (zeige CDKN1A Antikörper)), p27(KIP1) and cyclin E (zeige CCNE1 Antikörper) persisted within post-mitotic keratinocytes of the pre-cortex, whereas p57(KIP2 (zeige CDKN1C Antikörper)) protein decreased but became nuclear.

6. Taken together, these data clearly show that FKBP3 (zeige FKBP3 Antikörper)/Sp1 (zeige PSG1 Antikörper)/HDAC2 (zeige HDAC2 Antikörper)/p27 (zeige PAK2 Antikörper) control cell proliferation during non-small cell lung cancer development.

7. Sumoylation of K73 (zeige KRT73 Antikörper) site of cyclin-dependent kinase inhibitor 1B (p27kip1) is critical to the nuclear-cytoplasmic translocation of p27kip1, which is mediated by RAN binding protein 2 (zeige RANBP2 Antikörper) and CRM1 (zeige XPO1 Antikörper) protein. Sumoylation of p27kip1 promotes the proliferation of cholangiocarcinoma QBC939 cells

8. loss of CDKN1B increased the prevalence of cell cycle regulator defects in immature T-ALL, usually only ascribed to CDKN2A/B deletions, and that CDKN1B deletions frequently coincide with expression of MEF2C (zeige MEF2C Antikörper), considered as one of the driving oncogenes in immature early T-cell precursor (ETP) ALL

9. This study reveals a molecular pathway involving lncRNA GAS5/E2F1 (zeige E2F1 Antikörper)/P27(Kip1) which regulates cell proliferation and could be a potential therapeutic target in prostate cancer.

10. miR (zeige MLXIP Antikörper)-155-5p promotes fibroblast cell proliferation and inhibits FOXO (zeige FOXO3 Antikörper) signaling pathway by negative modulation of both FOXO3 (zeige FOXO3 Antikörper) and CDKN1B in vulvar lichen sclerosis

Zebrafish Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) Interaktionspartner

Cow (Bovine) Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) Interaktionspartner

1. p27Kip1 inhibition has an effect on proliferation of bovine corneal endothelial cells by RNA interferenc

Pig (Porcine) Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) Interaktionspartner

1. FoxO1a (zeige FOXO1 Antikörper) can regulate p27kip nuclear localization

2. the activation of Rac1 due to the cell-cell contact plays a critical role in the transcriptional up-regulation of p27Kip1 in vascular endothelial cells.

Mouse (Murine) Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) Interaktionspartner

1. Findings demonstrate functional interplay between a transcriptional regulator and p27(kip1) to mediate neuroprogenitor cell cycle exit, as well as to promote radial migration through a molecular mechanism consistent with suppression of RhoA (zeige RHOA Antikörper) signaling.

2. Specifically, the proteins p18INK4C (zeige CDKN2C Antikörper), p21CIP1 (zeige CDKN1A Antikörper) and p27KIP1 seem to play an outstanding role in the maintenance of the differentiated state of adipocytes.

3. Data show that both bone marrow-derived and gastric epithelial cells contribute to the increased gastric cancer susceptibility of p27-deficient Helicobacter pylori (H. pylori) -infected mice.

4. Our results revealed that CKS1 (zeige CKS1B Antikörper) is involved in normal glutamatergic synapse development and dendritic spine maturation in adult hippocampus through modulating p27 stability.

5. p27kip1 is involved in the decisive step around cell-cycle exit and plays an important role in activity-regulated and functionally relevant adult hippocampal neurogenesis.

6. p27(Kip1)-target genes are involved in cell adhesion and cell signaling in mouse embryonic fibroblasts.

7. This study demonstrates that LMP2A uses the role of MYC (zeige MYC Antikörper) in the cell cycle, particularly in the p27(kip1) degradation process, to accelerate lymphomagenesis in vivo.

8. Study reports that p27 normally exerts a negative feedback on p21 (zeige D4S234E Antikörper) expression: p27 directly represses the expression of the transcription factor Pitx2 (zeige PITX2 Antikörper) which in turn maintains decreased p21 (zeige D4S234E Antikörper) levels. Consequently, in cells lacking p27, de-repression of Pitx2 (zeige PITX2 Antikörper) causes the up-regulation of p21 (zeige D4S234E Antikörper) showing a new mechanism by which p27 regulates cell cycle progression by transcriptionally regulating the expression of Pitx2 (zeige PITX2 Antikörper) and p21 (zeige D4S234E Antikörper).

9. Fbxo7 (zeige FBXO7 Antikörper)-deficient immature thymocytes failed to undergo expansion in the thymus due to a lack of Cdk6 (zeige CDK6 Antikörper) activity, while mature T cells showed enhanced proliferative capacity upon T-cell receptor engagement due to reduced p27 levels. These studies reveal differential cell cycle regulation by Fbxo7 (zeige FBXO7 Antikörper) at different stages in T-cell development.

10. systems-level control of cell cycle arrest by pRB (zeige PGR Antikörper)-E2F (zeige E2F1 Antikörper) and p27-CDK (zeige CDK4 Antikörper) regulation, is reported.