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anti-CDKN1B (CDKN1B) Antikörper

Bezeichnung:: anti-Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) Antikörper (CDKN1B)

Auf www.antikoerper-online.de finden Sie aktuell 717 Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) Antikörper von 32 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen CDKN1B Proteine (21) und CDKN1B Kits (12) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 778 CDKN1B Produkte verfügbar.

Synonyme:: AA408329, AI843786, Cdki1b, CDKN1B, cdkn1bl, CDKN4, Kip1, MEN1B, MEN4, p27, p27Kip1, sb:cb611, wu:fb63g10, wu:fb64g10, wu:fe18e03

Alle Antikörper anzeigen	Gen	GeneID	UniProt
	CDKN1B	1027	P46527
	CDKN1B	83571
	CDKN1B	12576	P46414
Alle Spezies anzeigen Weitere Synonyme anzeigen

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Weitere Produktkategorien zu CDKN1B Antikörper

Am meisten referenzierte anti-CDKN1B Antikörper

Human Polyclonal CDKN1B Primary Antibody für IHC - ABIN6713417 : Liao, Ye, Zhang, Li, Wang, Cui, Qi, Wu, Jiao, Xie, Zhang, Wang, Ding: MicroRNA-30b functions as a tumour suppressor in human colorectal cancer by targeting KRAS, PIK3CD and BCL2. in The Journal of pathology 2014 (PubMed)
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Human Monoclonal CDKN1B Primary Antibody für BI, IP - ABIN967391 : Gorospe, Liu, Xu, Chrest, Holbrook: Inhibition of G1 cyclin-dependent kinase activity during growth arrest of human breast carcinoma cells by prostaglandin A2. in Molecular and cellular biology 1996 (PubMed)
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Human CDKN1B Primary Antibody für IHC - ABIN966733 : Eguchi, Herschenhous, Kuzushita, Moss: Helicobacter pylori increases proteasome-mediated degradation of p27(kip1) in gastric epithelial cells. in Cancer research 2003 (PubMed)
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Human Polyclonal CDKN1B Primary Antibody für IHC - ABIN966734 : Le, Claret, Lammayot, Tian, Deshpande, LaPushin, Tari, Bast: The role of cyclin-dependent kinase inhibitor p27Kip1 in anti-HER2 antibody-induced G1 cell cycle arrest and tumor growth inhibition. in The Journal of biological chemistry 2003 (PubMed)
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Human Polyclonal CDKN1B Primary Antibody für FACS, IF (p) - ABIN672621 : Sun, Yang, Luo, Wang, Chen, Zhang, Wang, Li: Thyroid hormone inhibits the proliferation of piglet Sertoli cell via PI3K signaling pathway. in Theriogenology 2014 (PubMed)
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Human Polyclonal CDKN1B Primary Antibody für IHC (p), WB - ABIN546389 : McAllister, Becker-Hapak, Pintucci, Pagano, Dowdy: Novel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions. in Molecular and cellular biology 2002 (PubMed)
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Human Polyclonal CDKN1B Primary Antibody für IHC (p), WB - ABIN537704 : Wingate, Zhang, McGarhen, Bedrosian, Harper, Keyomarsi: The tumor-specific hyperactive forms of cyclin E are resistant to inhibition by p21 and p27. in The Journal of biological chemistry 2005 (PubMed)
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Human Polyclonal CDKN1B Primary Antibody für IHC (p), WB - ABIN537705 : Kawamata, Inagaki, Mizumura, Sugimoto, Sakajiri, Ohyanagi-Hara, Oshimi: Methylation status analysis of cell cycle regulatory genes (p16INK4A, p15INK4B, p21Waf1/Cip1, p27Kip1 and p73) in natural killer cell disorders. in European journal of haematology 2005 (PubMed)
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Human Polyclonal CDKN1B Primary Antibody für IHC (p), WB - ABIN537706 : Andreu, Lledó, Poch, Ivorra, Albero, Martínez-Climent, Montiel-Duarte, Rifón, Pérez-Calvo, Arbona, Prósper, Pérez-Roger: BCR-ABL induces the expression of Skp2 through the PI3K pathway to promote p27Kip1 degradation and proliferation of chronic myelogenous leukemia cells. in Cancer research 2005 (PubMed)
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Weitere Antikörper gegen CDKN1B Interaktionspartner

Human Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) Interaktionspartner

Results indicated that WAVE2 and ACTN4 were necessary for the regulation of p27 phosphorylation. Also, WAVE2 and p27 cooperatively promote the motility and invasiveness of pancreatic ductal adenocarcinoma cells.
p27 regulated the cell cycle and inhibited cell proliferation by affecting formation of the cell cycle-dependent complex CDK6/CCND1, but did not directly affect the expression of CDK6 and CCND1.
HuD enhanced p27 mRNA translation by interacting with both the 5'-untranslated region (UTR) and the 3'-UTR of p27 mRNA, and consequently suppressed cell cycle progression and growth of pancreatic neuroendocrine tumors.
ER stress treatment generates a marginal increase in Gp78 endogenous levels, and this elevation effect was prominent for intracellular accumulation of p27 in cells. Taken together, our current findings suggest a valuable multifactorial regulatory mechanism and linkage of p27 with UPS pathway
genetic polymorphism of GAS5 may influence the development of gastric cancer and so could be a new marker of this disease. The link with disease may involve p27Kip1 expression.
This is the first report of AC026166.2-001 acting as a tumor suppressor in laryngeal squamous cell carcinoma by regulating the miR-24-3p/p27 axis.
UBCH7/UBE2L3 catalyzes the conjugation of heterotypic ubiquitin chains on p27(Kip1) that are proteolytically incompetent
our findings suggested that miR-222 may promote the progression of polycystic ovary syndrome by targeting p27 Kip1.
These results demonstrated that JSK could trigger cell cycle arrest at the G2/M phase and apoptosis in A549 and H460 cells, which was likely mediated via the p53/p21WAF1/CIP1 and p27KIP1 pathways. Overall, the results indicated that JSK may be used as an anticancer agent for the treatment of nonsmall cell lung cancer (NSCLC)
Study found that PSMD2 was markedly upregulated in breast cancer. High PSMD2 expression was significantly correlated with poor prognosis. PSMD2 knockdown inhibited cell proliferation and arrested cell cycle at G0/G1 phase in vitro, as well as suppressed tumor growth in vivo. Mechanically, PSMD2 physically interacted with p21 and p27 and mediated their ubiquitin-proteasome degradation with the cooperation of USP14.
BAP31 levels were significantly increased in tumor tissues from patients with gastric intestinal-type adenocarcinoma. Study in gastric cancer cell lines and mouse xenograft model found that BAP31 could combine with p27kip1 and regulate its proteasome degradation.
PHLPP2 stabilization by p27 mediates its inhibition of bladder cancer invasion by promoting autophagic degradation of MMP2 protein.
Theaflavin-3,3'-digallate (TF3) up-regulated the expression of p27 to induce G0/G1 cell cycle arrest in OVCAR-3 cells. Our study indicated that Chk2 and p27 were vital anticancer targets of TF3 and provided more evidence that TF3 might be a potent agent to be applied as adjuvant treatment for ovarian cancer.
Global analysis of p27 and cJun chromatin binding and gene expression shows that cJun recruitment to many target genes is p27 dependent, increased by p27 phosphorylation, and activates programs of epithelial-mesenchymal transformation and metastasis.
our results suggest that p27 may participate in the regulation of mitotic progression in a CDK-independent manner by modulating PRC1 activity.
Study shows that Cdk2/cyclin A-bound p27 samples lowly-populated conformations that provide access to the BCR-ABL and Src kinases promoting intra-assembly phosphorylation of p27 on distal T187. Even when tightly bound to Cdk2/cyclin A, intrinsic flexibility enables p27 to integrate and process signaling inputs, and generate outputs including altered Cdk2 activity, p27 stability, and, ultimately, cell cycle progression.
HP plays an important role in the development and progression of GC through silencing of CDH1, RUNX3, p21WAF and p27 expression
Rapamycin treatment increased the level of the p27(KIP1) cyclin-dependent kinase inhibitor, and rapamycin-induced ciliogenesis was abrogated in p27(KIP1)-depleted cells. These results indicate that mTORC1 inactivation induces ciliogenesis through p27(KIP1) upregulation, but not through autophagy.
we firstly demonstrate that BCRC-3 is down-regulated in BC tissues and cell lines for the first time. BCRC-3 is capable of functioning as ceRNA for miR-182-5p to regulate the expression of p27.
Our findings demonstrate that circYAP1 functions as a tumor suppressor in GC cells by targeting the miR-367-5p/p27 (Kip1) axis and may provide a prognostic indicator of survival in GC patients.

Zebrafish Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) Interaktionspartner

The retinoic acid pathway is activated in hair cell loss an regulates p27kip in hair cell regeneration.

Cow (Bovine) Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) Interaktionspartner

p27Kip1 inhibition has an effect on proliferation of bovine corneal endothelial cells by RNA interferenc

Pig (Porcine) Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) Interaktionspartner

FoxO1a can regulate p27kip nuclear localization
the activation of Rac1 due to the cell-cell contact plays a critical role in the transcriptional up-regulation of p27Kip1 in vascular endothelial cells.

Mouse (Murine) Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) Interaktionspartner

HuD enhanced p27 mRNA translation by interacting with both the 5'-untranslated region (UTR) and the 3'-UTR of p27 mRNA, and consequently suppressed cell cycle progression and growth of pancreatic neuroendocrine tumors.
the AMPK/p27(Kip1) pathway likely regulates the autophagy/apoptosis balance in aged MuSCs and may be a potential target for improving muscle regeneration in older individuals.
Findings indicate that p27Kip1 is central for the decreased proliferation at lower temperature, since p27Kip1 KO mouse embryonic fibroblasts (MEFs) hardly increased their doubling time in cold conditions, whereas wild-type MEFs significantly delayed proliferation in response to cold stress.
defective p27-phospho-S10 modifies endothelial behavior and promotes aneurysm formation via COX-2 activation.
Our results reveal both major pathways of p27(Kip1) degradation are required for the accelerated Burkitt lymphoma (BL) development driven by LMP2A in our BL model.
The data characterize mitochondrial p27 as a common denominator that improves mitochondria-dependent processes and define an increase in mitochondrial p27 as a new mode of action of caffeine.
after irradiation, loss of p27 is associated to accumulation of residual DNA damage and increased number of mitotic aberration. We show that p27 expression is necessary to preserve genomic integrity and for correct recognition and clearing-out of aberrant cells.
Although expressed in all retinal cell types, p27 is required to maintain the quiescence of specific cell types including bipolar cells, Muller glia, and cones while it is dispensable for preventing cell cycle reentry in other cell types
Findings demonstrate functional interplay between a transcriptional regulator and p27(kip1) to mediate neuroprogenitor cell cycle exit, as well as to promote radial migration through a molecular mechanism consistent with suppression of RhoA signaling.
Specifically, the proteins p18INK4C, p21CIP1 and p27KIP1 seem to play an outstanding role in the maintenance of the differentiated state of adipocytes.
Data show that both bone marrow-derived and gastric epithelial cells contribute to the increased gastric cancer susceptibility of p27-deficient Helicobacter pylori (H. pylori) -infected mice.
Our results revealed that CKS1 is involved in normal glutamatergic synapse development and dendritic spine maturation in adult hippocampus through modulating p27 stability.
p27kip1 is involved in the decisive step around cell-cycle exit and plays an important role in activity-regulated and functionally relevant adult hippocampal neurogenesis.
p27(Kip1)-target genes are involved in cell adhesion and cell signaling in mouse embryonic fibroblasts.
This study demonstrates that LMP2A uses the role of MYC in the cell cycle, particularly in the p27(kip1) degradation process, to accelerate lymphomagenesis in vivo.
Study reports that p27 normally exerts a negative feedback on p21 expression: p27 directly represses the expression of the transcription factor Pitx2 which in turn maintains decreased p21 levels. Consequently, in cells lacking p27, de-repression of Pitx2 causes the up-regulation of p21 showing a new mechanism by which p27 regulates cell cycle progression by transcriptionally regulating the expression of Pitx2 and p21.
Our findings demonstrate a direct role for microRNAs in controlling the rate of liver regeneration after injury.
Fbxo7-deficient immature thymocytes failed to undergo expansion in the thymus due to a lack of Cdk6 activity, while mature T cells showed enhanced proliferative capacity upon T-cell receptor engagement due to reduced p27 levels. These studies reveal differential cell cycle regulation by Fbxo7 at different stages in T-cell development.
systems-level control of cell cycle arrest by pRB-E2F and p27-CDK regulation, is reported.
Results demonstrated that the addition of oncogenic mutations, such as loss of p27 or p53, promotes ovarian tumor development from the benign adenomas of germ cell-deficient ovaries.

CDKN1B Antigen-Profil

Beschreibung des Gens

This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.

Alternative names and synonyms associated with CDKN1B

cyclin dependent kinase inhibitor 1B (CDKN1B) Antikörper
cyclin-dependent kinase inhibitor 1Bb (cdkn1bb) Antikörper
cyclin-dependent kinase inhibitor 1B (Cdkn1b) Antikörper
cyclin dependent kinase inhibitor 1B (Cdkn1b) Antikörper
cyclin-dependent kinase inhibitor 1Ba (cdkn1ba) Antikörper

AA408329 Antikörper
AI843786 Antikörper
Cdki1b Antikörper
CDKN1B Antikörper
cdkn1bl Antikörper
CDKN4 Antikörper
Kip1 Antikörper
MEN1B Antikörper
MEN4 Antikörper
p27 Antikörper
p27Kip1 Antikörper
sb:cb611 Antikörper
wu:fb63g10 Antikörper
wu:fb64g10 Antikörper
wu:fe18e03 Antikörper

Bezeichner auf Proteinebene für CDKN1B

cyclin-dependent kinase inhibitor 1B , cyclin-dependent kinase inhibitor 1b (p27, kip1) , fb64g10 , kip1 , p27 , cyclin-dependent kinase inhibitor 1B (p27, Kip1) , cyclin-dependent kinase inhibitor p27 , p27Kip1 , Cyclin-dependent kinase inhibitor 1B (p27 Kip1) , Cyclin-dependent kinase inhibitor 1B (p27, Kip1) , cyclin-dependent kinase inhibitor p27/Kip1 , Cyclin-dependent kinase inhibitor p27 , cyclin-dependent kinase inhibitor 1b, like

GENE ID	SPEZIES
1027	Homo sapiens
368329	Danio rerio
374106	Gallus gallus
697188	Macaca mulatta
100127219	Ovis aries
466947	Pan troglodytes
512613	Bos taurus
403429	Canis lupus familiaris
83571	Rattus norvegicus
397584	Sus scrofa
12576	Mus musculus
100689401	Cricetulus griseus
100729359	Cavia porcellus
493958	Felis catus
402862	Danio rerio

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Show all anti-Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) Antikörper with Pubmed References