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These results provided evidence supporting the oncogenic potential of NFAT3 (zeige NFATC4 Proteine) and suggested that CDK3-mediated phosphorylation of NFAT3 (zeige NFATC4 Proteine) has an important role in skin tumorigenesis.
The analysis of tumor and matched normal lung tissues indicates that miR (zeige MLXIP Proteine)-150 downregulation in lung tumors correlates with higher CDK3 levels. In addition, miR (zeige MLXIP Proteine)-150 transfection experiments with cancer-derived cell lines reveal that miR (zeige MLXIP Proteine)-150-mediated CDK3 suppression directly induces growth inhibition.
High Cdk3-promoted epithelial-mesenchymal transition through activating AP-1 (zeige FOSB Proteine) is involved in colorectal cancer metastasis.
Data indicate that microRNA miR (zeige MLXIP Proteine)-214 has tumor-suppressive activity in hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) through inhibition of E2F2 transcription factor (E2F2 (zeige E2F2 Proteine)), cyclin (zeige PCNA Proteine)-dependent kinases CDK3 and CDK6 (zeige CDK6 Proteine).
Mir (zeige MLXIP Proteine)-873 inhibits ESR1 (zeige ESR1 Proteine) activity and cell growth via targeting CDK3.
CDK3 is associated with the progression of NPC (zeige NPC1 Proteine), and may be a potential biomarker for prediction of the prognosis of patients with NPC (zeige NPC1 Proteine).
The Walleye dermal sarcoma virus cyclin (zeige PCNA Proteine) functions as a structural ortholog of cyclin C (zeige CCNC Proteine) in spite of its limited amino acid sequence identity with C cyclins or with any known cyclins and activates Cdk8 (zeige CDK8 Proteine) and Cdk3.
A non-cdk8 (zeige CDK8 Proteine)-associated cellular pool of cyclin C (zeige CCNC Proteine) combines with cdk3 to stimulate pRb (zeige RB1 Proteine) phosphorylation at S807/811 during the G0/G1 transition, and this phosphorylation is required for cells to exit G0 efficiently.
Expression level of cdk3 is higher in human cancer cell lines and glioblastoma tissue compared with normal brain tissue. cdk3 phosphorylates activating transcription factor 1 (ATF1 (zeige AFT1 Proteine))and enhances the transactivation and transcriptional activities of ATF1 (zeige AFT1 Proteine).
Results indicated that CDKL3 (zeige CDKL3 Proteine) may be involved in proliferation of cells surrounding the brain ventricle where neuronal progenitor cells are enriched during the late embryo st
CDKL3 (zeige CDKL3 Proteine) is involved in neuronal morphogenesis during development.
This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0.
cyclin-dependent kinase 3
, cell division protein kinase 3