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Human CDK1 Protein expressed in Wheat germ - ABIN1348775
Ovejero-Benito, Frade: Brain-derived neurotrophic factor-dependent cdk1 inhibition prevents G2/M progression in differentiating tetraploid neurons. in PLoS ONE 2013
the miR (zeige MLXIP Proteine)-181a was down-regulated in NSCLC and miR (zeige MLXIP Proteine)-181a inhibited the cell proliferation by regulating CDK1 expression.
Thus, Cyclin A/Cdk1 phosphorylation primes MYPT1 for Plk1 binding. These data demonstrate cross-regulation between Cyclin A/Cdk1-dependent and Plk1-dependent phosphorylation of substrates during mitosis to ensure efficient correction of kinetochore microtubule attachment errors necessary for high mitotic fidelity.
It has been suggested that through interaction with miR (zeige MLXIP Proteine)-490-3p DLEU1 may influence the expression of CDK1, CCND1 (zeige CCND1 Proteine) and SMARCD1 (zeige SMARCD1 Proteine) protein, subsequently promoting the development and progression of ovarian carcinoma.
The present study suggested that abnormal activation of CDK1 was implicated in the proliferation and apoptosis regulation of ovarian cancer cells, which might due to the aberrant regulations of the upstream Chk1 (zeige CHEK1 Proteine)-CDC25C (zeige CDC25C Proteine) and P53 (zeige TP53 Proteine)-P21WAF1 signaling pathway.
CDK1-mediated mitotic phosphorylation of PDZ-binding kinase (zeige PBK Proteine) is involved in cytokinesis and inhibits its oncogenic activity.
DNM2 (zeige DNM2 Proteine) is a substrate for CDK1-dependent phosphorylation, which plays an important role in the regulation of human sperm acrosomal exocytosis.
These findings suggest that Cdc2 is positively associatd with the development of taxol resistance. The Cdc2 inhibitor, purvalanol A, enhanced the cytotoxic effects of taxol through Op18/stathmin (zeige STMN1 Proteine).
With tissue microarrays of hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) patients, we determined the prognostic values of the core genes in the network and found that RAD21 (zeige RAD21 Proteine), CDK1, and HDAC2 (zeige HDAC2 Proteine) expression levels were negatively associated with overall survival for HCC (zeige FAM126A Proteine) patients. The multivariate Cox (zeige COX8A Proteine) regression analyses suggested that CDK1 was an independent prognostic factor, which was validated in an independent case cohort.
this study shows that CDK1 is a prognostic biomarker for lung adenocarcinoma
cytoplasmic Cdk1 expression is elevated in ovarian cancer and predicts a poor overall survival
Results provide evidence that cdc2/cyclin B1 (zeige CCNB1 Proteine) kinase activation was synchronous with the initial appearance of cytoskeletal lesions in mouse with Niemann-Pick disease type C.
CDK1, Aurora-B (zeige AURKC Proteine), and Rho-kinase (zeige ROCK2 Proteine) phosphorylate keratin 5 (zeige KRT36 Proteine)/14.
the ability of oocytes to mature, as well as oocyte CDK1 levels, were dependent on follicle size, but CDK1 expression in oocytes from preantral follicles was not acutely altered by the activity of follicle stimulating hormone (FSH (zeige BRD2 Proteine)).
our results show that the phosphorylation of 4E-BP1 (zeige EIF4EBP1 Proteine) promotes translation at the onset of meiosis to support the spindle assembly and suggest an important role of CDK1 and mTOR (zeige FRAP1 Proteine) kinases in this process
Study shows that Cdk1 phosphorylates Ska3 to promote its direct binding to the Ndc80 complex (Ndc80C), a core outer kinetochore component, also show that this phosphorylation occurs specifically during mitosis and is required for the kinetochore localization of the Ska complex.
loss of LAR (zeige PTPRF Proteine) activity resulted in reduced activity of CDK1.
CDK1 is a positive regulator of the IFN signaling pathway. The overexpression of CDK1 might contribute to the abnormally amplified type I IFN signaling in systemic lupus erythematosus.
Cdk1-induced desmin (zeige DES Proteine) phosphorylation is required for efficient separation of desmin (zeige DES Proteine)-IFs and generally detected in muscular mitotic cells in vivo.
using in vitro dephosphorylation assays, we demonstrate that Mastl (zeige MASTL Proteine) promotes persistent MPS1 phosphorylation by inhibiting PP2A (zeige PPP2R2B Proteine)/B55 (zeige MINK1 Proteine)-mediated MPS1 dephosphorylation rather than affecting Cdk1 kinase activity. Our findings establish a key regulatory function of the Greatwall (zeige MASTL Proteine) kinase/Mastl (zeige MASTL Proteine) - PP2A (zeige PPP2R2B Proteine)/B55 (zeige MINK1 Proteine) pathway in preventing premature SAC (zeige ADCY10 Proteine) silencing
oxidative stress-induced (zeige SQSTM1 Proteine) DNA damage of mouse zygotes triggers the cell cycle checkpoint, which results in G2/M cell cycle arrest, and that phospho-Cdc25B (zeige CDC25B Proteine) (Ser323), phospho-Cdc25C (zeige CDC25C Proteine) (Ser216), and phospho-Cdc2 (Tyr15) participate in activating the G2/M checkpoint.
intestinal clock controls the expression of key cell cycle regulators, such as cdc2, wee1 (zeige WEE1 Proteine), p21 (zeige CDKN1A Proteine), PCNA (zeige PCNA Proteine) and cdk2 (zeige CDK2 Proteine), but only weakly influences cyclin B1 (zeige CCNB1 Proteine), cyclin B2 (zeige CCNB2 Proteine) and cyclin E1 (zeige CCNE1 Proteine) expression.
Oligosaccharides of hyaluronan induce angiogenesis through distinct CD44 (zeige CD44 Proteine) and RHAMM (zeige HMMR Proteine)-mediated signalling pathways involving Cdc2 and gamma-adducin (zeige ADD3 Proteine).
Here the authors show that CPEB4 activity is regulated by ERK2- and Cdk1-mediated hyperphosphorylation. These phosphorylation events additively activate CPEB4 in M-phase by maintaining it in its monomeric state.
the fine-tuning of Cdc6 (zeige CDC6 Proteine) accumulation is essential to ensure two meiotic waves of Cdk1 activation and to avoid unscheduled DNA replication during meiotic maturation.
equilibrium between CDK1 and PP2A (zeige PPP2R2B Proteine) specifies the timing of M-phase entry and exit and regulates the dynamics of cyclin B degradation upon M-phase exit in Xenopus laevis first embryonic mitosis.
CDK1 activation proceeds with concomitant inhibition by CDC6 (zeige CDC6 Proteine), which tunes the timing of the M-phase entry during the embryonic cell cycle
Xenopus Cdk1-AS rescues HT2-19 cells from apoptosis.
Ras suppresses cyclin-dependent kinase 1 in a complex manner: It induces continuous accumulation of cyclin B2 (zeige CCNB2 Proteine), but also causes persistent inhibitory phosphorylation of tyr (zeige TYR Proteine)-15-cyclin-dependent kinase 1.
Greatwall (zeige MASTL Proteine) kinase and cyclin B-Cdk1 are both critical constituents of M-phase-promoting factor.
By promoting CtIP (zeige RBBP8 Proteine)-dependent resection of double-strand break (DSB) ends while preventing Rad51 chromatin assembly, Cdk1 inhibits both the nonhomologous and homologous modes of DSB repair during mitosis.
Examination of H1 histones reveals isoform-specific regulation by Cdk1 and RanGTP; mitotic Cdk1 functions to enhance H1 binding in egg extracts and embryos
Cdc2 displays cytoskeleton-dependent localization in blastomere cortex during Xenopus embryonic cell cycle.
Physical interaction between p115 and Cdk1, suggests that p115 sequesters or re-localizes Cdk1 during mitosis to allow the complete activation of Cdk1 and consequently correct progression through mitosis in Drosophila imaginal cells.
Here the authors show that CDK1 phosphorylation of GNU negatively regulates PNG (zeige ETS2 Proteine) kinase activity.
Cdk1 waves are not controlled by the mitotic switch but by a double-negative feedback between Cdk1 and Chk1 (zeige CHEK1 Proteine). In Drosophila embryos, Cdk1 positive feedback serves primarily to ensure the rapid onset of mitosis, while wave propagation is regulated by S phase events.
Cdk1 phosphorylates the conserved centriole protein Sas-4 during mitosis. This creates a Polo-docking site that helps recruit Polo to daughter centrioles.
Our results indicate that the cyclic changes in Gwl (zeige MASTL Proteine) localization at mitotic entry and exit are directly regulated by the antagonistic cyclin B-Cdk1 and PP2A (zeige PPP2R2B Proteine)-Tws enzymes
Cdk1 mediates the role of TARA and CycA (zeige CCNA2 Proteine) in sleep regulation.
Y15 phosphorylation can both inhibit Cdk1 catalytic activity and de-stabilize Cdk1/Cyclin (zeige PCNA Proteine) complexes, whereas T161 phosphorylation facilitates stable interactions between cyclin B and Cdk1.
Phosphorylation of Cdk1 on Y15 appeared to be crucial for developmental and DNA damage-induced G2-phase checkpoint arrest, consistent with other evidence that Myt1 (zeige MYT1 Proteine) is the major Y15-directed Cdk1 inhibitory kinase at this stage of development.
nonmuscle myosin II regulation by Cdc2 activity
CDK1 activation may be the cell cycle regulated event that determines the timing of emi1 destruction.
CDK7 (zeige CDK7 Proteine) and CCNH (zeige CCNH Proteine) activate CDC2 by T161 phosphorylation and make up CDK-activating kinase (zeige CDK7 Proteine), which is required for normal meiotic progression during porcine oocyte maturation.
Results describe the expression of maternal cyclin B1 (zeige CCNB1 Proteine) and Cdc2 during in vitro maturation of porcine oocytes.
Data demonstrate the presence of a novel structure in the cortex of porcine oocytes that comprises ERES and transiently accumulates CDC2 prior to germinal vesicle breakdown.
insufficient amount of Cdc2 and continuous activation of Wee1 B are the cause of meiotic failure of small oocytes in pigs
These results suggest that the inhibitory phosphorylation of CDC2, which is catalyzed by pigWee1B (zeige WEE2 Proteine), but not pigMyt1, is involved in the meiotic arrest of porcine oocytes.
Data show that phosphatidylcholine (PC) biosynthesis is repressed by disruption of the core cell cycle regulator CYCLIN-DEPENDENT KINASE A;1 (CDKA;1) and that this repression is reliant on PHOSPHATIDIC ACID PHOSPHOHYDROLASE (PAH).
Cyclin-dependent kinase A (CDKA) phosphorylates eukaryotic initiation factor 4A (zeige DDX39 Proteine) (eIF4A)eIF4A1 (zeige EIF4A1 Proteine) and eIF4A2 (zeige EIF4A2 Proteine) on a conserved threonine residue (threonine-164) within the RNA-binding motif.
CDKA;1 and CYCD3;2 are required for the terminal division in the stomatal lineage.
Data indicate that the in vivo confirmation of substrates of CDKA;1 showing a direct link between cell proliferation and the control of the redox state.
The crucial function of CDKA;1 is the control of the plant Retinoblastoma homolog RBR1 and codepletion of RBR1 and CDKA;1 rescued most defects of cdka;1 mutants.
Expression of a dominant negative CDKA;1 allele under the control of the STM (zeige SHMT1 Proteine) promoter perturbs post-embryonic development. Inhibition of CDK (zeige CDK4 Proteine) activity at the shoot apex (zeige APEX1 Proteine) results in premature differentiation of shoot apical meristem cells.
When a single cdka;1 sperm was delivered, either female gamete could be fertilized leading to similar proportions of seeds containing either a single endosperm or a single embryo.
However, we show here that the DNA damage checkpoint in Arabidopsis can also operate independently of the phosphorylation of CDKA;1.
CDC2A participates in the fertilization process of endosperm
The balance between cell division and differentiation is regulated through the interaction between CDKA;1 and the antiphosphatase PAS2. [CDKA;1]
These results reveal a crucial and conserved role of phosphorylation of the N terminus of Bora for Plk1 activation and mitotic entry.
CDK-1 regulates PLK-1 activity during mitosis in C. elegans embryos through multisite phosphorylation of the PLK-1 activator SPAT (zeige AGXT Proteine)-1
Conversion of microtubule-organizing center state involves the conserved C. elegans centrosome protein SPD-2/CEP192 and cell-cycle-dependent kinase activity from the mitotic cell.
Our results support a model in which CYB (zeige CSTB Proteine)-2.1/2/CDK-1 antagonize CUL-2 (zeige CUL2 Proteine) activity to promote stabilization of PAR-6 (zeige PARD6A Proteine) levels during polarization of the early C. elegans embryo.
CDK-1 activates PLK-1 via SPAT (zeige AGXT Proteine)-1 phosphorylation to promote entry into mitosis.
model in which Wnt signaling and CDK-1 modify WRM-1 in a temporal and spatial manner to unmask an intrinsic polarity cue required for proper orientation of the endomesoderm cell division axis
results indicate that CDC-25.1 is required for maintaining proper rate of germline mitotic cell cycle; propose that CDC-25.1 regulates the rate of germline mitotic cell cycle by counteracting WEE (zeige WEE1 Proteine)-1.3 and by positively controlling CDK-1
CDK-1 blocks rotation by inhibiting dynein association with microtubules.
Use of loss- and gain-of-function genetic approaches demonstrates that CYY-1, a cyclin (zeige PCNA Proteine) box-containing protein, drives synapse removal in this process.
NPP-16 and CDK-1 function to arrest prophase blastomeres in C. elegans embryos
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
cell cycle controller CDC2
, cell division control protein 2 homolog
, cell division cycle 2, G1 to S and G2 to M
, cell division protein kinase 1
, p34 protein kinase
, cyclin-dependent kinase 1
, cell cycle p34 CDC2 kinase protein
, cell division cycle 2 homolog A
, cell division cycle control protein 2a
, Cell division cycle control protein 2
, cell division cycle 2
, Cell division control protein 2 homolog 1
, cell division control protein 2-A
, cell division cycle 2 like
, cell division protein kinase 1-A
, cyclin-dependent kinase 1-A
, p34 protein kinase 1
, cdc2 kinase
, cyclin dependent kinase
, cyclin-dependent kinase
, cell division cycle 2 protein
, protein cdc2 kinase
, putative cyclin-dependent kinase A family protein
, cell division control protein 2 homolog 2
, cell division control protein 2-B
, cell division protein kinase 1-B
, cyclin-dependent kinase 1-B
, p34 protein kinase 2
, DNA polymerase delta
, DNA-directed DNA polymerase delta 1
, polymerase (DNA directed), delta 1, catalytic subunit 125kDa
, Cell division control protein 2 homolog
, Cell division protein kinase 1
, Cell division control protein 2