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Human Polyclonal CDC25C Primary Antibody für IF (p), IHC (p) - ABIN1387108
Ghate, Chaudhuri, Sarkar, Sajem, Panja, Rout, Mandal: An antioxidant extract of tropical lichen, Parmotrema reticulatum, induces cell cycle arrest and apoptosis in breast carcinoma cell line MCF-7. in PLoS ONE 2013
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Human Polyclonal CDC25C Primary Antibody für IF (p), IHC (p) - ABIN746993
Yin, Jiang, Peng, Cui, Zhou, He, Zuo, Ouyang, Fan, Fang: The molecular mechanism of G2M cell cycle arrest induced by AFB1 in the jejunum. in Oncotarget 2016
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Human Monoclonal CDC25C Primary Antibody für IHC, ELISA - ABIN1724739
Busch, Barton, Morgenstern, Götz, Günther, Noll, Montenarh: The G2/M checkpoint phosphatase cdc25C is located within centrosomes. in The international journal of biochemistry & cell biology 2007
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Human Polyclonal CDC25C Primary Antibody für IHC - ABIN965834
Chen, Zhang, Bower, Lu, Leonard, Ding, Castranova, Piwnica-Worms, Shi: Arsenite-induced Cdc25C degradation is through the KEN-box and ubiquitin-proteasome pathway. in Proceedings of the National Academy of Sciences of the United States of America 2002
Overexpression of the CDK1 and CDC25A may have a role in the pathogenesis of the NFPA.
Mdm2 (zeige MDM2 Antikörper) overexpression and Cdc25C downregulation delay cell cycle progression through the G2/M phase.
Xanthatin functions as a DNA-damaging agent in non-small cell lung carcinomas by activating Chk1 (zeige CHEK1 Antikörper)-mediated DDR (zeige DDR1 Antikörper) and lysosome-mediated degradation of Cdc25C.
Myelodysplastic syndrome -related P95 (zeige NBN Antikörper) point mutants of SRSF2 (zeige SRSF2 Antikörper) lead to alternative splicing of CDC25C in a manner that is not dependent on the DNA damage response.
The aim of this review is to shed light on the role of four different phosphatases (PTEN, PP2A (zeige PPP2R4 Antikörper), CDC25 (zeige RASGRF1 Antikörper) and DUSP1 (zeige DUSP1 Antikörper)) in five different solid tumors (breast cancer, lung cancer, pancreatic cancer, prostate cancer and ovarian cancer), in order to better understand the most frequent and aggressive primary cancer of the central nervous system, glioblastoma.
Data show that TRIB2 (zeige TRIB2 Antikörper)-mediated degradation of CDC25C is associated with lysine-48-linked CDC25C polyubiquitination driven by the TRIB2 (zeige TRIB2 Antikörper) kinase-like domain.
the biology of the activation/deactivation of CDC25 (zeige RASGRF1 Antikörper) by kinases/phosphatases to maintain the level of CDK (zeige CDK4 Antikörper)-cyclin (zeige PCNA Antikörper) activities and thus the genomic stability
the knockdown of CDC25C can reduce both the radiotherapy sensitivity and the proliferation activity of EC9706 cells.
results identify CDC25C as a downstream target of the mutated tyrosine kinase (zeige TXK Antikörper) FLT3 (zeige FLT3 Antikörper)-ITD affecting cell-cycle regulation in a model of AML (zeige RUNX1 Antikörper)
Suggest that the p53 (zeige TP53 Antikörper)-p21 (zeige CDKN1A Antikörper)-DREAM-CDE/CHR pathway regulates p53 (zeige TP53 Antikörper)-dependent repression of Survivin (zeige BIRC5 Antikörper), CDC25C, and PLK1 (zeige PLK1 Antikörper) in HCT116 cells.
oxidative stress-induced (zeige SQSTM1 Antikörper) DNA damage of mouse zygotes triggers the cell cycle checkpoint, which results in G2/M cell cycle arrest, and that phospho-Cdc25B (zeige CDC25B Antikörper) (Ser323), phospho-Cdc25C (Ser216), and phospho-Cdc2 (zeige CDK1 Antikörper) (Tyr15) participate in activating the G2/M checkpoint.
The role of Cdc25c and Cdc25b (zeige CDC25B Antikörper) in activating G2/M cell cycle checkpoint in zygote.
an asymmetrical distribution pattern for Cdc25c transcripts in 2-cell embryos.
CDC25A (zeige CDC25A Antikörper) and CDC25B (zeige CDC25B Antikörper) but not CDC25C compensate for each other to maintain the proliferative capacity of intestinal epithelial stem and progenitor cells
A single cell cycle genes homology region controls transcription of the cdc25C gene and is able to cooperate with E2F (zeige E2F1 Antikörper) or Sp1 (zeige SP1 Antikörper)/3 sites
Cdc25A (zeige CDC25A Antikörper), or possibly other phosphatases, is able to functionally compensate for the loss of Cdc25B (zeige CDC25B Antikörper) and Cdc25C in mice
The present study was aimed to investigate the possibility that selenium (Se)-induced oxidative stress mediated alterations in Cdc25c and p21 (zeige D4S234E Antikörper) may cause modulations in the CDC2 (zeige CDK1 Antikörper)/Cyclin B1 (zeige CCNB1 Antikörper) complex responsible for G2/M phase checkpoint in spermatogenesis.
In Lzts1 (zeige LZTS1 Antikörper)(-/-) mouse embryo fibroblasts (MEFs), Cdc25C degradation was increased during M phase, resulting in decreased Cdk1 (zeige CDK1 Antikörper) activity.
PP2A:B56delta as a key upstream regulator of Cdk1 (zeige CDK1 Antikörper) activity upon exit from mitosis
Blocking mitotic entry by adding the catalytic subunit of protein kinase A results in increased wee1 Ser549 phosphorylation and maintenance of cdc25C.
These observations identify PP2A (zeige PPP2R2B Antikörper)/B56delta as a central checkpoint effector and suggest a mechanism for controlling 14-3-3 (zeige YWHAQ Antikörper) interactions to promote mitosis.
In Xenopus oocytes, p42 MAPK (zeige MAPK1 Antikörper) interacts with hypophosphorylated Cdc25 before meiotic induction. During meiotic induction, p42 MAPK (zeige MAPK1 Antikörper) phosphorylates Cdc25 at three sites, increasing Cdc25's phosphatase activity.
This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.
cell division cycle 25 homolog C (S. pombe)
, m-phase inducer phosphatase 3-like
, cell division cycle 25 homolog C
, cell division cycle 25C
, Dual specificity phosphatase Cdc25C
, M-phase inducer phosphatase 3
, dual specificity phosphatase Cdc25C
, dual specificity phosphatase CDC25C
, mitosis inducer CDC25
, phosphotyrosine phosphatase
, protein phosphatase 1, regulatory subunit 60
, cell cycle phosphatase CDC25C
, cell division cycle control protein 25C