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TLE1 is a potential immunohistochemical marker for glomus tumors
studies indicate Bit1 (zeige PTRH2 Proteine) is an inhibitor of EMT (zeige ITK Proteine) and metastasis in lung cancer and hence can serve as a molecular target in curbing lung cancer aggressiveness
Authors present data indicating that TLE1 is rapidly excluded from the nucleus following epidermal growth factor receptor (zeige EGFR Proteine) pathway activation, an effect that likely accounts for its inability to mediate effective repression under such conditions.
TLE1 is not a stand-alone diagnostic immunohistochemical marker for synovial sarcoma
Data suggest TLE1 is highly expressed in macrophages cultured in vitro, in macrophages of atherosclerotic plaques, and in macrophages of visceral adipose tissue from obese women; expression of TLE1 is up-regulated upon macrophage activat (zeige IL4 Proteine)ion.
TLE1 has a role in regulating epithelial-to-mesenchymal transition in A549 cells through its repressive effect on E-cadherin (zeige CDH1 Proteine)
There was no difference in TLE-1 staining between different subtypes of synovial sarcoma
GrG1 is involved in pancreatic cell differentiation, establishing a monohormonal beta cell identity. Grg1 is the predominant Groucho expressed in human beta-cells but acts functionally similarly to Grg3.
TCF (zeige HNF4A Proteine)/TLE tetramer complex promotes structural transitions of chromatin to mediate repression.
signaling and increases the expression (zeige NOTCH1 Proteine)of recombinant recognition sequence binding protein at the Jkappa site (RBP-J) and transducin-like enhancer of Split (zeige RBPJ Proteine)(TLE).
Demethylation of TLE1 promoter region activates the self-expression in diabetic mice intestinal epithelium cells (IECs). Subsequently, TLE1, through the transcriptional suppression on expression of Hes1 (zeige HES1 Proteine), contributes to the aberrant differentiation of IECs in DM mice.
Data suggest that Tle1 is highly expressed in activated macrophages cultured in vitro; expression of Tle1 is low in resting macrophages and is up-regulated upon macrophage activation (here, stimulated with recombinant human interleukin-4 (zeige IL4 Proteine)).
Loss of Tle1 not only results in increased phosphorylation and activation of proinflammatory NF-kappaB but also results in decreased Hes1 (hairy and enhancer of split-1), a negative regulator of inflammation in macrophages
TLE1/TLE3-NuRD corepressor complex facilitates Tbx20 (zeige TBX20 Proteine)-dependent transcriptional repression.
Data indicate that cAMP activates Notch (zeige NOTCH1 Proteine) signaling and increases the expression of recombinant recognition sequence binding protein at the Jkappa site (RBP-J (zeige RBPJ Proteine)) and transducin (zeige GNAT1 Proteine)-like enhancer of Split (TLE).
Studies suggest that TLE1 and TLE3 might also play roles independent of HESX1 (zeige HESX1 Proteine) by interacting with other transcription factors like PROP1 (zeige PROP1 Proteine).
Grg1-S may operate in conjunction with beta-catenin (zeige CTNNB1 Proteine) and Tcf (zeige HNF4A Proteine) factors to regulate vertebrate gut (zeige GUSB Proteine) epithelial cell differentiation
Grg6 (zeige TLE6 Proteine) interferes with the binding of Gro (zeige CXCL1 Proteine)/TLE1 to BF-1 (zeige FOXG1 Proteine) and does not repress transcription when targeted to DNA.
Inhibition of cortical neuron differentiation by Groucho/TLE1 requires interaction with WRPW, but not Eh1 (zeige EPHX1 Proteine), repressor peptides
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
, enhancer of split groucho 1
, enhancer of split groucho-like protein 1
, transducin-like enhancer of split 1, homolog of Drosophila E(sp1)
, transducin-like enhancer protein 1
, groucho-related protein 1
, transducin-like enhancer of split 4 (homolog of Drosophila E(spl)) - like
, transducin-like enhancer of split 1
, transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)