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Suggest that Pygo2 has a tumor promoting function related to Wnt/ss-catenin signaling activity during intestinal tumor initiation and progression.
Transcriptional cofactors Bcl9 (zeige BCL9 Proteine), Bcl9l (zeige BCL9L Proteine) and Pygo1 (zeige PYGO1 Proteine)/2 act independently of beta-catenin (zeige CTNNB1 Proteine) to ensure proper enamel formation.
It analyzed Wnt1 (zeige WNT1 Proteine)-cre(+/-)::Pygo2(-/-) mice in which the beta-catenin (zeige CTNNB1 Proteine) co-activator gene, Pygopus 2 (Pygo2), is deleted specifically in neural crest cells.
These findings identify Pygo2 as an important regulator of Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) function in skin epithelia and p53 (zeige TP53 Proteine) activation as a prominent downstream event of beta-catenin (zeige CTNNB1 Proteine)/Pygo2 action in stem cell activation.
these results suggest that Pygo2 acts at a step downstream of mammary stem cell accumulation to facilitate transformation, and that it regulates the tumor initiating capacity and lineage preference of the already transformed mammary cells, in MMTV-Wnt1 (zeige WNT1 Proteine) mice.
even in the absence of the potentially redundant Pygo1 (zeige PYGO1 Proteine), Pygo2 does not require the H3K4me2/3 binding activity to sustain its function during mouse development
Mouse pygo2 expression was detected in the developing epidermis and hair follicles, which suggests that mpygo2 might mediate the effect of this signaling pathway in mouse skin.
In mammals, the Pygo1 (zeige PYGO1 Proteine)/Pygo2 genes are not absolutely required for canonical Wnt (zeige WNT2 Proteine) signaling in most developing systems, but rather function as quantitative transducers, or modulators, of Wnt (zeige WNT2 Proteine) signal intensity
Pygo2 can function in the Wnt (zeige WNT2 Proteine) pathway, but its activity in lens development is Wnt (zeige WNT2 Proteine) pathway-independent
ablation of pygo2 expression causes defects in morphogenesis of both ectodermally and endodermally derived tissues, including brain, eyes, hair follicles, and lung
Elevated PYGO2 expression in primary prostate adenocarcinoma is a potential risk factor for biochemical recurrence.
Overexpression of Pygo2 facilitated the expression of P-glycoprotein, which acts as a drug efflux pump, by promoting the transcription of MDR1 at the MDR1 promoter loci, resulting in acceleration of the efflux of paclitaxel in human glioma cells.
We also determined the effect of Pygo2 on the sensitivity of breast tumors resistant to doxorubicin in a mouse model. Finally, RNA samples from 64 paired patient tumors (before and after chemotherapy) highly and significantly overexpressed Pygo2 and/or MDR1 after treatment, thus underlining a pivotal role for the Pygo2-mediated Wnt/b-catenin pathway in the clinical chemoresistance of breast cancer.
Findings are consistent with a model in which acetylation of Pygo2 by CBP/p300 (zeige CREBBP Proteine) family members in the active TCF (zeige HNF4A Proteine)/beta-catenin (zeige CTNNB1 Proteine) complex occurs coincident with histone acetylation and may be required for the recycling of Pygo2 away from the complex subsequent to target gene activation.
The activation of its expression by ERalpha (zeige ESR1 Proteine) and/or specificity protein-1 (SP1 (zeige SP1 Proteine)) suggests hPYGO2 as a theranostic target for hormone therapy responsive and refractory breast cancer.
Pygo2 functions as a prognostic factor for glioma due to its up-regulation of H3K4me3 and promotion of MLL1/MLL2 complex recruitment.
this study demonstrated that SNPs in the coding region of Pygo2 might be one of the causative factors in idiopathic oligospermia and azoospermia, resulting in male infertility.
Our findings suggest that Pygopus-2 may be an important predictor of poor outcome in HCC (zeige FAM126A Proteine) patients, and could serve as a novel biomarker for HCC (zeige FAM126A Proteine).
Pygopus-2 over-expression is associated with hepatic carcinoma.
Pygo2 is a common node downstream of oncogenic Wnt (zeige WNT2 Proteine) and Akt (zeige AKT1 Proteine) signaling pathways.
Involved in signal transduction through the Wnt pathway.
pygopus homolog 2
, pygopus 2