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Our study revealed an association between Pygo2 function and obesity or diabetes. we showed that Pygo2 exhibited a declined expression pattern during adipocyte differentiation, resulting in an attenuated Wnt/beta-catenin output level. We further showed impaired glucose tolerance and decreased systemic insulin sensitivity in Pygo2-deficient mice.
Suggest that Pygo2 has a tumor promoting function related to Wnt/ss-catenin signaling activity during intestinal tumor initiation and progression.
Transcriptional cofactors Bcl9, Bcl9l and Pygo1/2 act independently of beta-catenin to ensure proper enamel formation.
It analyzed Wnt1-cre(+/-)::Pygo2(-/-) mice in which the beta-catenin co-activator gene, Pygopus 2 (Pygo2), is deleted specifically in neural crest cells.
These findings identify Pygo2 as an important regulator of Wnt/beta-catenin function in skin epithelia and p53 activation as a prominent downstream event of beta-catenin/Pygo2 action in stem cell activation.
these results suggest that Pygo2 acts at a step downstream of mammary stem cell accumulation to facilitate transformation, and that it regulates the tumor initiating capacity and lineage preference of the already transformed mammary cells, in MMTV-Wnt1 mice.
even in the absence of the potentially redundant Pygo1, Pygo2 does not require the H3K4me2/3 binding activity to sustain its function during mouse development
Mouse pygo2 expression was detected in the developing epidermis and hair follicles, which suggests that mpygo2 might mediate the effect of this signaling pathway in mouse skin.
In mammals, the Pygo1/Pygo2 genes are not absolutely required for canonical Wnt signaling in most developing systems, but rather function as quantitative transducers, or modulators, of Wnt signal intensity
Pygo2 can function in the Wnt pathway, but its activity in lens development is Wnt pathway-independent
ablation of pygo2 expression causes defects in morphogenesis of both ectodermally and endodermally derived tissues, including brain, eyes, hair follicles, and lung
Study finds canonical Wnt signaling to be predominantly active in the mesenchyme at the time when mPygo2 is required and demonstrate the dependence of Wnt signal transduction on mPygo2.
Pygo2 is involved in the chromatin remodeling events that lead to nuclear compaction of male germ cells
Pygo2 converges with Wnt/beta-catenin signaling on progenitor cell regulation and cell cycle gene expression.
Elevated PYGO2 expression in primary prostate adenocarcinoma is a potential risk factor for biochemical recurrence.
Overexpression of Pygo2 facilitated the expression of P-glycoprotein, which acts as a drug efflux pump, by promoting the transcription of MDR1 at the MDR1 promoter loci, resulting in acceleration of the efflux of paclitaxel in human glioma cells.
We also determined the effect of Pygo2 on the sensitivity of breast tumors resistant to doxorubicin in a mouse model. Finally, RNA samples from 64 paired patient tumors (before and after chemotherapy) highly and significantly overexpressed Pygo2 and/or MDR1 after treatment, thus underlining a pivotal role for the Pygo2-mediated Wnt/b-catenin pathway in the clinical chemoresistance of breast cancer.
Findings are consistent with a model in which acetylation of Pygo2 by CBP/p300 family members in the active TCF/beta-catenin complex occurs coincident with histone acetylation and may be required for the recycling of Pygo2 away from the complex subsequent to target gene activation.
The activation of its expression by ERalpha and/or specificity protein-1 (SP1) suggests hPYGO2 as a theranostic target for hormone therapy responsive and refractory breast cancer.
Pygo2 functions as a prognostic factor for glioma due to its up-regulation of H3K4me3 and promotion of MLL1/MLL2 complex recruitment.
this study demonstrated that SNPs in the coding region of Pygo2 might be one of the causative factors in idiopathic oligospermia and azoospermia, resulting in male infertility.
Our findings suggest that Pygopus-2 may be an important predictor of poor outcome in HCC patients, and could serve as a novel biomarker for HCC.
Pygopus-2 over-expression is associated with hepatic carcinoma.
Pygo2 is a common node downstream of oncogenic Wnt and Akt signaling pathways.
The results of the present study suggest a novel involvement of Pygo in the promotion of rRNA transcription in cancer cells
We conclude that abnormal Pygo2 protein expression may be a marker for advanced non-small cell lung cancer
PYGO2 is identified as a new molecular marker of invasive tumors in esophageal squamous cell carcinoma.
SNPs in the coding region of Pygo2 gene may be one of the causative factors in idiopathic oligospermia and azoospermia, resulting in male infertility.
Pygo2 directly occupies the promoters of multiple histone genes and enhances the acetylation of lysine 56 in histone H3.
Pygo2 is highly expressed in and promotes the growth of glioma cells
The study demonstrated that Pygo2 was highly expressed in glioma tissue and required for growth of glioblastoma cells.
Data show that Pygo2 associates with MLL2 histone methyltransferase and STAGA histone acetyltransferase to facilitate their interaction with beta-catenin and Wnt1-induced, TCF/LEF-dependent transactivation in breast cancer cells.
Pygo2 PHD is the only known PHD finger that is capable of interacting simultaneously with two functional ligands, B9L and BCL9
The Expression of pygopus 2 protein mRNA levels were significantly higher in the epithelial ovarian cancer cell lines.
Involved in signal transduction through the Wnt pathway.
pygopus homolog 2
, pygopus 2