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A loss of epidermal PLCdelta1 impairs epidermal barrier function through dysregulation of Ca2 (zeige CA2 Proteine)+ and p38 mitogen-activated protein kinase (zeige MAPK14 Proteine) (MAPK (zeige MAPK1 Proteine)) signaling. This study also reveals a possible link among PLCdelta1 downregulation, p38 MAPK (zeige MAPK14 Proteine) hyperactivation, and barrier defects in psoriasis-like skin inflammation.
PLCD1 acts as a tumour suppressor, by KIF3A (zeige KIF3A Proteine)-mediated suppression of ERK1/2/beta-catenin (zeige CTNNB1 Proteine)/MMP7 (zeige MMP7 Proteine) signalling, at least in part, in breast cancer.
Nine of the 32 (28.1%) iCCA (zeige PRRT2 Proteine) patients had gene mutations at chromosome 3p, totaling 11 mutations across five genes. Those included five (15.6%) BAP1 (zeige RNF2 Proteine) mutations, two each (6.3%) of CACNA2D3 (zeige CACNA2D3 Proteine) and RASSF1 (zeige RASSF1 Proteine) mutations, and one each (3.1%) of ATG7 (zeige ATG7 Proteine) and PLCD1 mutations. Six (18.8%) cases had concurrent loss of chromosome 3p and gene mutations.
The PLCdelta1 negatively regulates autophagy, and PLCdelta1 suppression contributes to the tolerance of CRC cells harboring KRAS mutations to nutrient deprivation and anti-cancer drug treatment.
Phospholipase C delta 1 is both a KLF15-regulated gene and a novel repressor of airway smooth muscle hypertrophy.
High PLC (zeige HSPG2 Proteine) delta expression is associated with breast cancer.
slow phase of Gi/o-mediated TRPC4 (zeige TRPC4 Proteine) activation was diminished by inhibiting RhoA (zeige RHOA Proteine) or enhancing PLCdelta function
Neuropeptide Y (zeige NPY Proteine) decreased PLCD1 expression in HUVECs.
PLC (zeige HSPG2 Proteine)-delta1 and TRPV6 (zeige TRPV6 Proteine) are critical actor of Ca(2 (zeige CA2 Proteine)+) homeostasis in CF human bronchial epithelial cells.
Ectopic expression of PLCD1 inhibits breast tumor cell proliferation in vivo by inducing apoptosis and suppressed tumor cell migration by regulating cytoskeletal reorganization.
Results show that de novo polarisation of the embryo at the 8-cell stage is directed by phospholipase C (PLC) and protein kinase C (PKC).
PLCd1 negatively regulates lipopolysaccharide-induced production of IL-1b (zeige IL1B Proteine) and Fc gamma receptor (zeige FCGR1A Proteine)-mediated phagocytosis in macrophages.
Data show that phospholipase C delta1 (PLCD1) transfection can induce the apoptosis of CAPAN-1 and BXPC-3 pancreatic cancer cells, arrest the cell cycle in G0 /G1 phase.
the Ca(2 (zeige CA2 Proteine)+) dependence of the interaction between PRIP (zeige NCOA6 Proteine)-C2 and Syt1 (zeige SYT1 Proteine)-C2A was attributed to Ca(2 (zeige CA2 Proteine)+) binding with Syt1 (zeige SYT1 Proteine)-C2A, but not PRIP (zeige NCOA6 Proteine)-C2, using a series of mutants prepared from both C2 domains.
Expression of PLCdelta1 is increased in ALS mouse spinal cord and in neurons from ALS mice. Genetic ablation of this protein in ALS mice significantly increases survival
Identification, characterization and regulatory properties of a novel PLCD1 isoform in mouse.
Plcd1 and Plcd3 (zeige PLCd3 Proteine) have synergistic effects on the murine hair follicle in specific regions of the body surface.
Loss of phospholipase Cdelta1 from keratinocytes causes features of interleukin-17 (zeige IL17A Proteine)-associated inflammatory skin diseases.
Results suggest that phospholipase C delta(1) is required for skin stem cell lineage commitment.
the PLC (zeige HSPG2 Proteine)-delta1 promoter is under the control of NF-kappaB (zeige NFKB1 Proteine), which mediates the expression of PLC (zeige HSPG2 Proteine)-delta due to Abeta42
This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1
, phosphoinositide phospholipase C-delta-1
, phospholipase C-III
, PLC-delta 1
, phospholipase C delta 1 Lf
, phospholipase C delta-1
, phospholipase C-delta-1
, Phospholipase C-delta1
, phosphoinositide phospholipase C
, phospholipase C delta 1 long form
, LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1