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anti-Human PKC beta Antikörper:
anti-Mouse (Murine) PKC beta Antikörper:
anti-Rat (Rattus) PKC beta Antikörper:
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Human Polyclonal PKC beta Primary Antibody für IHC - ABIN966836
Zhang, Liao, Dufau et al.: Phosphatidylinositol 3-kinase/protein kinase Czeta-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated derepression [corrected] of ... in Molecular and cellular biology 2006
Show all 5 Pubmed References
Human Polyclonal PKC beta Primary Antibody für IF, IHC - ABIN871421
Castoria, Migliaccio, Di Domenico, Lombardi, de Falco, Varricchio, Bilancio, Barone, Auricchio: Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells. in Molecular and cellular biology 2004
Show all 5 Pubmed References
Cow (Bovine) Polyclonal PKC beta Primary Antibody für WB - ABIN2786693
Tatematsu, Yoshimoto, Okajima, Tanizawa, Kuroda: Identification of ubiquitin ligase activity of RBCK1 and its inhibition by splice variant RBCK2 and protein kinase Cbeta. in The Journal of biological chemistry 2008
An exaggerated vasoconstriction response to dexmedetomidine, an alpha-2 adrenergic agonist, has been associated with SNP rs9922316 in the gene for protein kinase C (zeige PKC Antikörper) type beta ( PRKCB).
our study indicated that PKC alpha and beta appeared coping with oncogenic Ras or mutated Akt to maintain the balance of the homeostasis in cancer cells. Once these PKC isoforms were suppressed, the redox state in the cancer cells was disrupted, which elicited persistent oncogenic stress and subsequent apoptotic crisis.
PKC beta would sensitize cervical cancer cells to chemotherapy via reducing the chemotherapy induced autophagy in cancer cells.
Loss of PRKCB2 expression is associated with colorectal cancer.
significantly different gene expressions of BECN1 and PRKCB between the control and the Alzheimer's disease (AD) groups and of CDKN2A between the control and the preclinical AD groups, are reported.
a primary functional variant of PRKCB (rs35015313) was identified by genotype imputation using a phased panel of 1,070 Japanese individuals from a prospective, general population cohort study and subsequent in vitro functional analyses. These results may lead to improved understanding of the disease pathways involved in primary biliary cholangitis.
our findings identify PRKCB gene as a novel candidate gene for familial Meniere's Disease (MD )and its expression gradient in supporting cells of the organ of Corti deserves attention, given the role of supporting cells in K(+ )recycling within the endolymph, and its apical turn location may explain the onset of hearing loss at low frequencies in MD
Activation of the Pro-Oxidant PKCbetaII-p66Shc (zeige SHC1 Antikörper) Signaling Pathway Contributes to Pericyte Dysfunction in Skeletal Muscles of Patients With Diabetes With Critical Limb Ischemia
Taken together, these data argue for a complex mechanism of PKC-beta-dependent regulation of SH (zeige POLD3 Antikörper)CA (p66) activation invol (zeige SIGLEC1 Antikörper)ving Ser(139) and a motif surroun (zeige SIGLEC1 Antikörper)ding Ser(213).
The study aimed to identify a small set of genetic signatures that may reliably predict the individuals with a high genetic propensity to heroin addiction. A set of 4 genes (JUN (zeige JUN Antikörper), CEBPB (zeige CEBPB Antikörper), PRKCB, ENO2 (zeige ENO2 Antikörper), or CEBPG (zeige CEBPG Antikörper)) could predict the diagnosis of heroin addiction with the accuracy rate around 85% in our dataset.
These results suggest that CD40-activated CD40L reverse signalling has striking and opposite effects on the growth and elaboration of dendrites among major classes of brain neurons by PKC-dependent mechanisms.
The absence of gut (zeige GUSB Antikörper) microbiota from birth was shown to be associated with decreased CREB (zeige CREB1 Antikörper) expression, followed by decreases of protein kinase C beta (PRKCB) and AMPA (zeige GRIA3 Antikörper) receptors expression, and an increase of phosphorylation CREB (zeige CREB1 Antikörper) (pCREB) expression.
These results provide a molecular explanation of how initiation of B cell activation (zeige BLNK Antikörper) discriminates substrate stiffness through a PKCbeta-mediated FAK (zeige PTK2 Antikörper) activation dependent manner.
propose that PKCbeta acts to suppress the degradation of FTO (zeige FTO Antikörper) protein and reveals the associated role of PKCbeta and FTO (zeige FTO Antikörper) in adipogenesis, suggesting a new pathway that affects the development of obesity and metabolic diseases
Cytosolic NELL2 specifically interacts with PKC beta isotypes and inhibits PKC beta1 through direct binding to the N-terminal pseudosubstrate domain of PKC beta1.
Taken together, these data argue for a complex mechanism of PKCbeta-dependent regulation of p66 (zeige POLD3 Antikörper) activation involving Ser (zeige SIGLEC1 Antikörper)(139) and a motif surrounding Ser (zeige SIGLEC1 Antikörper)(213).
Translocation of PKC-betaII from the cytoplasm to membranes is required for phagocytosis of apoptotic cells and is inhibited by soluble beta-glucan
repressor of myogenesis; opposes calcineurin function
a new mechanism by which PKC-beta activation promotes EC dysfunction caused by the de-regulation of the IL-18 (zeige IL18 Antikörper)/IL-18BP (zeige IL18BP Antikörper) pathway, leading to increased VCAM-1 (zeige VCAM1 Antikörper) expression, monocyte/macrophage adhesion, and accelerated atherosclerotic plaque formation in diabetes
These results demonstrate the importance of PKCbetaII in chronic lymphocytic leukemia-like disease progression and suggest a role for PKCalpha (zeige PKCa Antikörper) subversion in creating permissive conditions for leukemogenesis.
The study identified the serine phosphorylation (p-Ser (zeige SIGLEC1 Antikörper)) sites induced by PKC-Beta activation or AGT (zeige AGT Antikörper), which inhibits insulin (zeige INS Antikörper)-induced p-Tyr (zeige TYR Antikörper) sites on IRS2 (zeige IRS2 Antikörper) and its signals in endothelial cells.
ET-1 (zeige EDN1 Antikörper)-mediated myocardial contractile dysfunction during cardioplegia involves activation of protein kinase C beta II.
The PKCalpha (zeige PKCa Antikörper), PKCbeta1, and PKCbeta2 mRNA levels tended to be lower in ischemia-reperfused than in sham-operated eyes in both the retinal arteries and the neuroretina.
Increases in epicardial perivascular adipose tissue leptin (zeige LEP Antikörper) exacerbate coronary endothelial dysfunction in MetS (zeige MARS Antikörper) via a PKC-beta-dependent pathway.
first study to show the expression and cellular localization of PKC beta I in the retina of pigs with development, and these results suggest that PKC beta I, in accordance with PKC alpha (zeige PKCa Antikörper), plays important roles in signal transduction pathways in the pig retina with development
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
, protein kinase C beta type
, protein kinase C, beta 1 polypeptide
, protein kinase C beta-II
, protein kinase C, beta 1
, protein kinase C beta I
, protein kinase C beta II
, protein kinase C beta 1
, protein kinase C, beta
, protein kinase C beta 2