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our findings demonstrate that DKK2 functions as a tumor suppressor through inhibiting cell proliferation and inducing apoptosis via regulating Wnt (zeige WNT2 Proteine) signaling during breast tumorigenesis.
Knock down of the dickkopf (zeige DKK1 Proteine) WNT (zeige WNT2 Proteine) signaling pathway inhibitor 2 (DKK2) resulted in a significant suppression of HOXD10 (zeige HOXD10 Proteine), HOXD11 (zeige HOXD11 Proteine) and HOXD13 (zeige HOXD13 Proteine) while over-expression of DKK2 and stimulation with factors of the WNT (zeige WNT2 Proteine) signaling pathway.
epigenetic silencing of Wnt (zeige WNT2 Proteine) antagonists was associated with gastric carcinogenesis, and concurrent hypermethylation of SFRP2 (zeige SFRP2 Proteine) and DKK2 could be a potential marker for a prognosis of poor overall survival.
the genotyping and functional findings are consistent with the hypothesis that DKK2 is a tumor suppressor; by selectively retaining a transcriptionally inactive DKK2 allele, the reduction of DKK2 function results in unchecked Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling, contributing to hepatocellular carcinoma oncogenesis.
The present report suggested that DKK2 downregulation suppressed the proliferation and invasion of prostate cancer cells by inhibiting the Wnt/betacatenin signaling pathway.
these findings reveal that the miR (zeige MLXIP Proteine)-187-5p-DKK2 pathway regulates Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling, cell growth, and apoptosis. Our findings provide the first evidence of a role for miR (zeige MLXIP Proteine)-187-5p in promotion of B-cell ALL.
Genetic variant in DKK2 gene is associated with gallbladder cancer.
targeting of DKK2 by miR (zeige MLXIP Proteine)-154 leads to upregulation of beta-catenin (zeige CTNNB1 Proteine) expression and activation of the classical Wnt (zeige WNT2 Proteine) signaling pathway and cardiac fibroblasts.
MiR (zeige MLXIP Proteine)-21 overexpression was significantly correlated with the DKK2-/beta-catenin (zeige CTNNB1 Proteine)- immunohistochemical phenotype.
Data indicate that inhibiting dickkopf-related protein 2 (DKK2)with siDKK2 reduced the expression of DKK2, but had no effect on leptin (zeige LEP Proteine) expression.
Data (including data from studies in transgenic mice) suggest that Dkk2 secreted from pericytes promotes angiogenesis and neurogenesis/neural regeneration via Angpt1 (zeige ANGPT1 Proteine)/Tie2 (zeige TEK Proteine)/Wnt (zeige WNT2 Proteine) signaling; here, overexpression of Dkk2 in diabetic mice enhances penile angiogenesis/neural regeneration and restores erectile function. (Dkk2 = dickkopf-2; Angpt1 (zeige ANGPT1 Proteine)= angiopoietin-1 (zeige ANGPT1 Proteine); Tie2 (zeige TEK Proteine) = endothelial-specific receptor tyrosine kinase Tie2 (zeige TEK Proteine))
Dkk2 deletion results in alterations of liver morphology leading to an increased frequency of liver cancer
Spermatogenesis-associated protein 3 (Spata3) and dickkopf-related protein 2 (Dkk2) were confirmed to interact with MIC3. The tandem repeat EGF (zeige EGF Proteine) domains of MIC3 were critical in mediating the interactions with the identified host proteins. The results show that MIC3 interacts with host proteins that are involved in reproduction, growth, and development.
these data reveal a novel mechanism that the Bmp4 (zeige BMP4 Proteine)-Msx1 (zeige MSX1 Proteine) pathway and Osr2 control tooth organogenesis through antagonistic regulation of expression of secreted Wnt (zeige WNT2 Proteine) antagonists.
These findings demonstrate that DKK1 (zeige DKK1 Proteine) and DKK2 have differential roles in normalization and functionality of tumor blood vessels, in addition to angiogenesis.
Bmp4 (zeige BMP4 Proteine) signaling suppresses tooth developmental inhibitors in the tooth mesenchyme, including Dkk2 and Osr2, and synergizes with Msx1 (zeige MSX1 Proteine) to activate mesenchymal odontogenic potential for tooth morphogenesis and sequential tooth formation
Dickkopf2 is a Wnt (zeige WNT2 Proteine) antagonist involved in regulation of glucose metabolism
Both Dkk1 (zeige DKK1 Proteine) and Dkk2 inhibit Wnt (zeige WNT2 Proteine) signaling that regulates early myocardial proliferation; each compensates for loss of the other in that role.
there are distinct functions of DKK1 (zeige DKK1 Proteine) and DKK2 in controlling angiogenesis
Dkk2 was localized in the perichondral mesenchyme outlining the anterior cranial base in embryogenesis.
the DKK2 gene might have potential effects on body measurement traits and meat quality traits in Qinchuan cattle.
Kremen1 (zeige KREMEN1 Proteine) modulates Wnt (zeige WNT2 Proteine) activity by restricting the range of secreted Dkk (zeige DKK1 Proteine) proteins during collective cell migration in the posterior lateral line primordium
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6).
dickkopf 2 homolog
, dickkopf homolog 2
, dickkopf related protein-2
, dickkopf-related protein 2
, dickkopf 2
, dickkopf homolog 1
, dickkopf homolog 4