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our findings suggest that glucocorticoid-induced expression of Dkk-1 could be a key factor in modulating the differentiation ability of MSCs used for osteonecrosis of the femur head and other stem cell therapies.
MicroRNA152 inhibits cell proliferation of osteosarcoma through DKK1.
this study shows that DKK1 is increased in vitiligo (zeige MITF Proteine) in lesional and peri (zeige PLIN1 Proteine)-lesional skin of acral and non-acral lesions
Dkk-1 and PTH (zeige PTH Proteine) levels in psoriatic arthritis are lower than healthy female controls, in contrast with rheumatoid arthritis, in which they are increased
this study suggests that higher expression of DKK1 in the dermis induced senescence in melanocytes that may lead to hypopigmentation and play role in vitiligo (zeige MITF Proteine) pathogenesis
TNF-alpha (zeige TNF Proteine), DKK1, and OPG (zeige TNFRSF11B Proteine) have roles in pathogenesis of knee osteoarthritis
Serum level of DKK-1 is elevated in patients with rheumatoid arthritis (RA) compared to healthy controls, suggesting an important role of DKK-1 in the pathogenesis and treatment of RA [review].
the staining intensity of DKK1 was significantly stronger in the placentas of the severe preeclampsia group
Serum OPN (zeige SPP1 Proteine) and DKK1 levels of hepatocellular carcinoma patients could be considered as novel biomarkers showing prognostic significance after hepatectomy based on long-term survival data
These findings suggested that decreased circulating DKK-1 levels are associated with the development and severity of exudative age-related macular degeneration, and have potential to become a biomarker for exudative age-related macular degeneration.
The decreased expression of Dkk-1 in somatic cell nuclear transfer cotyledons that are prone to abnormal placentation suggests a role in cotyledon formation but the mechanism and regulatory control is yet to be revealed[DICKKOPF-1]
Palmatin effect on osteoarthritis is likely mediated via the Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) and Hedgehog (zeige SHH Proteine) signaling
DKK1 inhibits the WNT (zeige WNT2 Proteine) signaling pathway and improves pig oocyte maturation.
Association analysis showed that different genotypes of DKK1 were associated with loin muscle area.
activation of the FGF signaling pathway induces the formation of a dorsal axis with a complete head structure through the expression of chd (zeige CHRD Proteine) and subsequent maintenance of dkk1b expression levels.
Kremen1 (zeige KREMEN1 Proteine) modulates Wnt (zeige WNT2 Proteine) activity by restricting the range of secreted Dkk proteins during collective cell migration in the posterior lateral line primordium
Neuromast size is controlled by a balance between growth-promoting Wnt (zeige WNT2 Proteine) signaling activity in proliferation-competent cells and Wnt (zeige WNT2 Proteine)-inhibiting Dkk activity produced by differentiated sensory cells.
Dkk1b is abundantly produced by dense regions of androgen-regulated epidermal tubercles on the surfaces of adult male zebrafish pectoral fins
Data show that injury-dependent induction of Ascl1a suppressed expression of the Wnt (zeige WNT2 Proteine) signaling inhibitor, Dkk, and induced expression of the Wnt (zeige WNT2 Proteine) ligand, Wnt4a.
Collectively, our data strongly suggest that stress-related neurohormones, such as GCs (zeige UGCG Proteine), cause DP cells to secrete DKK1, which in turn inhibits hair growth.
Diabetic conditions increase the expression of DKK1.
DKK1 prevents lung metastasis of breast cancer cells but promotes breast-to-bone metastasis.
Membrane-bound DKK-1 is a novel Foxp3 (zeige FOXP3 Proteine) postive Treg cell derived mediator to maintain immunological tolerance in T-cell-mediated autoimmune colitis.
Dkk1 promotes hematopoietic regeneration via direct effects on hematopoietic stem cells, decreasing the levels of mitochondrial reactive oxygen species and suppressing senescence, and via indirect effects on bone marrow endothelial cells, inducing EGF (zeige EGF Proteine) secretion.
Recombinant Dkk1 suppresses beta-catenin (zeige CTNNB1 Proteine) target genes in myeloid-derived suppressor cells (MDSCs) from mice and humans and anti-Dkk1 loses its antitumor effects in mice lacking beta-catenin (zeige CTNNB1 Proteine) in myeloid cells or after depletion of MDSCs, demonstrating that Dkk1 directly targets MDSCs.
A negative feedback loop involving WNT6 (zeige WNT6 Proteine) and DKK1 attenuates canonical WNT6 (zeige WNT6 Proteine)-beta-catenin (zeige CTNNB1 Proteine) signaling, thereby allowing teratocarcinoma cells to differentiate.
Collectively, miR (zeige MLXIP Proteine)-9 promotes osteoblast differentiation of mesenchymal stem cells by suppressing DKK1 gene expression.
that Dkk1 negatively regulates BMP9 (zeige GDF2 Proteine)-induced osteogenic differentiation.
Disturbed oscillatory flow increases DKK1 expression. DKK1 knockdown attenuates OSS-induced monocyte adhesion and endothelial impairment. Genetic silencing of DKK1 limits atherogenesis in ApoE (zeige APOE Proteine)-/- mice.
dkk1 preferentially induced the expression of POX2, suggesting that dkk1 works as a morphogen (zeige SHH Proteine) to determine the different lineages.
N1 is a novel signaling domain within the intact protein that is responsible for the potent effects of Dkk1 on the induction and patterning of the body axis and heart
target Wnts of Dkk activity are maternal Wnt5a (zeige WNT5A Proteine) and Wnt11, and that both Wnts are essential for canonical and non-canonical signaling
This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.
dickkopf 1 homolog
, dickkopf related protein-1
, dickkopf-1 like
, dickkopf-like protein 1
, dickkopf-related protein 1
, dickkopf homolog 1
, dickkopf 1
, dickkopf protein