anti-DAAM1 (DAAM1) Antikörper

Human Dishevelled Associated Activator of Morphogenesis 1 (DAAM1) Interaktionspartner

1. Integrin alphavbeta3-associated DAAM1 is essential for collagen-induced invadopodia extension and cell haptotaxis in breast cancer cells

2. coiling phagocytosis is a mechanism for borrelial internalization by neuroglial cells mediated by Daam1

3. Results provide evidence that Daam1 activates RhoA to regulate Wnt5ainduced glioblastoma cell invasion.

4. DAAM1 organizes actin filaments into a nodal complex

5. Kank1 plays a crucial role in regulating the activity of RhoA through retrieving excess Daam1 and balancing the activities of RhoA and its effectors.

6. High Daam-1 expression may upregulate the Wnt/PCP pathway and cause idiopathic pulmonary arterial hypertension

7. Kif26b, together with Dvl3/Daam1, initiates cell polarity through the control of planar cell polarity-signaling pathway-dependent activation in endothelial cells.

8. Daam1 plays a dual role in the phagocytic uptake of borreliae.

9. A developmentally restricted function of miR-490 and its putative DAAM1 target are associated with exaggerated megakaryocytopoiesis and/or proplatelet formation.

10. Wnt5a promotes breast cancer cell migration via Dvl2/Daam1/RhoA.

11. DAAM1 is a formin required for centrosome re-orientation during cell migration.

12. Fli-I promotes the GTP-bound active Rho-mediated relief of the autoinhibition of Daam1 and mDia1. Thus, Fli-I is a novel positive regulator of Rho-induced linear actin assembly mediated by DRFs.

13. DAAM1 regulates endothelial cell growth through MT stabilization in a cell type-selective manner

14. DAAM1 was shown to bind to the SH3 domain of CIP4 in vivo.

15. Results report that Profilin1 is an effector downstream of Daam1 required for cytoskeletal changes during gastrulation.

16. The DAAM1 FH2 domain structure, determined at 2.25 A resolution, and DAAM1 actin binding activity

17. Crystal structure of human DAAM1 formin homology 2 domain

18. a carboxyl-terminal binding partner, Dvl, has a role in activation of Daam1

19. mDia1 and Daam1 are platelet actin assembly factors having distinct efficiencies, and they are directly regulated by Rho GTPases

Mouse (Murine) Dishevelled Associated Activator of Morphogenesis 1 (DAAM1) Interaktionspartner

1. The data suggested that Daam1 affected actin assembly during oocyte meiotic division via the regulation of fascin expression.

2. DAAM1 organizes actin filaments into a nodal complex

3. DAAM1 loss evokes invasive abilities of epithelial cells.

4. Daam1 knockout mice that were also homozygous for Daam2 had stronger noncompaction cardiomyopathy, severely reduced cardiac function, disrupted sarcomere structure, and increased myocardial proliferation.

5. Fascin and Daam1 coimmunoprecipitated from cell extracts, and silencing of fascin led to a striking loss of Daam1 localization to filopodial shafts. Purified fascin bound directly to Daam1; fascin recruited Daam1 to and stabilized Daam1 on actin bundles.

6. Daam1 is important for regulating filamentous actin assembly and organization, and consequently for cytoskeletal function in cardiomyocytes, which contributes to proper heart morphogenesis.

7. involved in pivotal steps in neuronal cell differentiation and movement

8. Daams are expressed in tissues known to require Wnts, so effectors of Wnt signaling during vertebrate development.

9. a carboxyl-terminal binding partner, Dvl, has a role in activation of Daam1

Xenopus laevis Dishevelled Associated Activator of Morphogenesis 1 (DAAM1) Interaktionspartner

1. Inturned links NPHP4 to Daam1 to control the subapical actin network in multiciliated cells

2. Daams are expressed in tissues known to require Wnts, so effectors of Wnt signaling during vertebrate development.

Zebrafish Dishevelled Associated Activator of Morphogenesis 1 (DAAM1) Interaktionspartner

1. Results indicate that Daam1a plays a key role in asymmetric habenular morphogenesis mediating the growth of dendritic and axonal processes in dorsal habenular neurons.

2. Pronephric tubulogenesis requires the Daam1/WGEF/Rho PCP pathway.

3. Daam1 is a dynamic coordinator of endocytosis and cytoskeletal remodeling underlying the convergent extension movement of notochord cells.