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Weitere Synonyme anzeigen
Human CTNNB1 Protein expressed in Wheat germ - ABIN1350670
Bian, Bai, Chapin, Le Moellic, Dong, Caplan, Sigworth, Navaratnam: Interactions between ?-catenin and the HSlo potassium channel regulates HSlo surface expression. in PLoS ONE 2011
Human CTNNB1 Protein expressed in Baculovirus infected Insect Cells - ABIN2004177
Hülsken, Birchmeier, Behrens: E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton. in The Journal of cell biology 1995
Show all 6 Pubmed References
temporal expression of CTNNB1 mRNA during dermal wound repair in the horse
Study validates the DNAJB1 (zeige DNAJB1 Proteine)-PRKACA (zeige PRKACA Proteine) fusion kinase as an oncogenic driver and candidate drug target for fibrolamellar hepatocellular carcinoma in mouse model in which tumorigenesis was significantly enhanced by genetic activation of beta-catenin.
BCAS2 (zeige BCAS2 Proteine) is an upstream regulator of beta-catenin gene expression and plays a role in dendrite growth at least partly through beta-catenin in the forebrain.
LncRNA MALAT1 is dysregulated in diabetic nephropathy and involved in high glucose-induced podocyte injury via its interplay with beta-catenin and SRSF1 (zeige SRSF1 Proteine).
These findings suggest a suppressive function for Ctbp2 (zeige CTBP2 Proteine) in reducing the protein level of beta-catenin, along with priming its position on core pluripotency genes to hinder beta-catenin deposition, which is central to commitment to the appropriate lineage.
Beta-catenin deletion in cathepsin K (CtsK (zeige CTSK Proteine))-expressing cells causes a severe loss of bone mass.
the GSK-3beta/beta-catenin signal pathway mediates the adverse effects of Ti particles on osteoblast differentiation and bone destruction
HIV and drug abuse mediate astrocyte senescence in a beta (zeige SUCLA2 Proteine)-catenin-dependent manner leading to neuronal toxicity.
The absence of hepatic beta-catenin predisposes mice to hepatic injury and fibrosis following iron overload, which was reminiscent of hemochromatosis (zeige HFE Proteine) and associated with enhanced steatohepatitis and fibrosis.
beta-catenin and p65 (zeige NFkBP65 Proteine) are activated in separate cellular compartments during liver regeneration, with p65 (zeige NFkBP65 Proteine) activity in nonparenchymal compartment contributing to the activation of hepatocyte beta-catenin, cyclin D1 (zeige CCND1 Proteine) expression, and subsequent proliferation
beta-catenin mutations were not involved in early-stage hepatocarcinogenesis induced by protoporphyrinogen oxidase (zeige PPOX Proteine) inhibitors
The results demonstrate that the argon plasma jet (zeige FBXL15 Proteine) has no adverse effects on fin regeneration and embryogenesis in zebrafish, and does not interrupt the (Wnt (zeige WNT2 Proteine))/beta-Catenin-signaling pathways.
The expression of c-kit and beta-catenin suggests that erythropoietin (zeige EPO Proteine) may exert a role in regeneration reducing the extent of tubular damage from the outset after gentamicin administration.
Net1-regulated beta-catenin activation plays a crucial role in the dorsal axis formation during zebrafish development.
Wnt (zeige WNT2 Proteine)/beta-catenin signaling induces expression of col12a1a/b and deposition of Collagen XII, which is necessary for axons to actively navigate the non-neural lesion site environment.
Mechanistically, Hif-3alpha2 binds to beta-catenin and destabilizes the nuclear beta-catenin complex.
Nuclear beta-catenin is an indication of an activated Wnt (zeige WNT2 Proteine) pathway, therefore suggesting a possible role for Wnt (zeige WNT2 Proteine) signalling during zebrafish tooth development and replacement.
Findings suggest that microRNA 19b (miR (zeige MYLIP Proteine)-19b) regulates laterality development and heart looping in embryos by targeting beta-catenin ctnnb1.
Custos binds to beta-catenin in a Wnt (zeige WNT2 Proteine) responsive manner without affecting its stability, but rather modulates the cytoplasmic to nuclear translocation of beta-catenin.
The role of the beta-catenin mechanosensitive pathway in mesoderm identity has been conserved over the large evolutionary distance separating zebrafish and Drosophila.
The Wnt (zeige WNT2 Proteine)/beta-catenin signaling pathway establishes neuroanatomical asymmetries and their laterality. (Review)
We identified the amphibian leap2 (zeige LEAP2 Proteine) gene which is highly related to its mammalian orthologues at both structural and sequence levels. The gene is expressed in the embryo mostly in the endoderm-derived tissues. Accordingly it is induced in pluripotent animal cap cells by FGF, activin or a combination of vegT/beta-catenin.
Together, these results indicate that capsaicin inhibits the patterning of the dorso-ventral and anterior-posterior body axes of embryo by repressing PP2A (zeige PPP2R2B Proteine) and thereby down-regulating the Wnt (zeige WNT2 Proteine)/beta-catenin signaling.
maternal Wnt (zeige WNT2 Proteine)/STOP signaling, but not beta-catenin signaling, has a role in cleavage after fertilization and cell cycle progression
Wnt (zeige WNT2 Proteine) signalling can benefit from nucleo-cytoplasmic shuttling of APC (zeige APC Proteine), Axin (zeige AXIN1 Proteine) and GSK3, although they are in general beta-catenin antagonising proteins.
Phosphoinositide 3-kinase and Rac (zeige AKT1 Proteine) polarization depend specifically on the N-cadherin (zeige CDH2 Proteine)-p120 catenin (zeige CTNND1 Proteine) complex, whereas myosin II light chain and actin filament polarization depend on the N-cadherin (zeige CDH2 Proteine)-beta-catenin complex.
HERG (zeige KCNH2 Proteine) channel activity is stimulated by beta-catenin
Zic3 (zeige ZIC3 Proteine) can suppress Wnt (zeige WNT2 Proteine)/beta-catenin signaling and control development of the notochord and Spemann's organizer.
Notch initially destabilises beta-catenin in a process that does not depend on its phosphorylation by GSK3
The tyrosine kinase receptor (zeige KDR Proteine), PTK7 (zeige PTK7 Proteine), is implicated in beta-catenin-dependent developmental processes.
Data show that alteration in beta-catenin expression, a core component of the CDH17/beta-catenin axis, in tumors affects serine peptidase inhibitor Kazal type 1 (SPINK1 (zeige SPINK1 Proteine)) serum levels in hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) patients.
Subsequent experiments documented that activation of EGFR (zeige EGFR Proteine) signaling induced by PD98059 increased the amount of beta-catenin in the nucleus. Taken together, our findings may elucidate a possible mechanism explaining the ineffectiveness of MEK (zeige MAP2K1 Proteine) inhibitors in breast cancer treatment and improve our understanding of the role of MEK (zeige MAP2K1 Proteine) in cancer
Although Genome-Wide Association studies have not been carried out in the field of alcohol-related hepatocellular carcinoma (HCC (zeige FAM126A Proteine)), common single nucleotide polymorphisms conferring a small increase in the risk of liver cancer risk have been identified. Specific patterns of gene mutations including CTNNB1, TERT (zeige TERT Proteine), ARID1A and SMARCA2 (zeige SMARCA2 Proteine) exist in alcohol-related HCC (zeige FAM126A Proteine). [review]
PAK1 (zeige PAK1 Proteine) expression, evaluated by immunohistochemistry, was positively correlated with pERK (zeige EIF2AK3 Proteine) and beta-catenin expression in lung tumors. Patients with high-PAK1 (zeige PAK1 Proteine), high-pERK (zeige EIF2AK3 Proteine), and high-nuclear beta-catenin tumors more frequently showed an unfavorable response to cisplatin-based chemotherapy when compared to their counterparts.
We conclude that a combined analysis of beta-catenin and p53 (zeige TP53 Proteine) could have prognostic importance as markers for predicting the progression of colorectal cancer and contribute to the identification of patients with a high risk of mortality
This study demonstrated that Desmoid-type fibromatosis carrying T41A or S45F mutations and WT beta-catenin are two distinct molecular subgroups with regard to beta-catenin stability, alpha-catenin (zeige CTNNA1 Proteine) affinity, and gene expression profiling.
Odd-skipped related 1 (OSR1 (zeige OSR1 Proteine)) downregulated the activity of the Wnt (zeige WNT2 Proteine) signaling pathway by suppressing the expression of sex-determining region Y (zeige SRY Proteine)-box 9 (SOX9 (zeige SOX9 Proteine)) and beta-catenin.
Data show that plakoglobin (zeige JUP Proteine) interacted with p53R175H and decreased beta-catenin protein levels.
beta-Catenin is important in the pathogenesis of salivary gland pleomorphic adenomas and adenoid cystic carcinomas
These results suggested that increased ANXA2 (zeige ANXA2 Proteine) and less expressed beta-catenin were correlated to adenomyosis-associated dysmenorrhea
Results highlight a potential role for the beta-catenin/Wnt (zeige WNT2 Proteine) and Notch (zeige NOTCH1 Proteine) signalling pathways during the infection of crypt cells by L. intracellularis.
Flutamide exposure led to decreased beta-catenin in corpus luteum of mid/late pregnancy.
beta-catenin signaling is involved in formation of contractile membranes by dedifferentiated retinal pigment epithelium cells.
Wnt3a (zeige WNT3A Proteine) produced a significant increase in heart valve interstitial cell number at day 4 and in the percentage of BrdU-positive nuclei at 24 h. The increase in proliferation was abolished by beta-catenin siRNA.
beta-catenin controls myocardin-related transcription factor-dependent transcription and emerges as a critical regulator of an array of cytoskeletal genes
beta-Catenin plays a critical role in mediating TGF-beta1 (zeige TGFB1 Proteine)-induced myofibroblast differentiation in aortic valve interstitial cells.
scratching-induced injury and repair of bronchial epithelial cells may involve inhibition of Glycogen synthase kinase 3beta activity which can lead to activation of the downstream signaling through beta-catenin
Data show that Wnt3a (zeige WNT3A Proteine) can inhibit the adipogenic differentiation of porcine AMSCs, and suggest that Wnt (zeige WNT2 Proteine)/beta-catenin signaling inhibits adipogenic differentiation potential and alters the cell fate from adipocytes to osteoblasts.
TNF-alpha (zeige TNF Proteine) inhibits adipogenesis through stabilization of beta-catenin protein in porcine preadipocytes.
Bovine herpesvirus 1 transiently increased beta-catenin protein levels in bovine kidney cells, but not in rabbit skin cells.
These results demonstrate that activation of AKT (zeige AKT1 Proteine) is required for gonadotropin regulation of CTNNB1 accumulation and subsequent ovarian E2 production.
beta-catenin, a transcription factor activated by the canonical Wnt signaling pathway, was frequently detected in bovine herpesvirus 1 ORF2-positive trigeminal ganglionic neurons of latently infected, but not mock-infected, calves.
These data demonstrate for the first time that FSH (zeige BRD2 Proteine) regulates CTNNB1 protein and WNT2 (zeige WNT2 Proteine) mRNA expressions in bovine granulosa cells, suggesting a potential role of canonical WNT (zeige WNT2 Proteine) signaling in ovarian steroidogenesis and follicular growth of cattle.
These data provide evidence that testosterone increases cellular beta-catenin content which promotes the expression of beta-catenin-targeted genes and myogenesis in the muscle-derived stem cells of cattle.
that beta-catenin is a plasma membrane-associated protein (zeige PDZK1IP1 Proteine) in airway smooth muscle that regulates active tension development, presumably by stabilizing cell-cell contacts and thereby supporting force transmission between neighboring cells.
This study demonstrated a relationship between the timing of the development of in vitro-produced bovine embryos and the distribution and localization of the junction protein beta-catenin.
TGF-beta3 (zeige TGFB3 Proteine) induces the chondrogenic differentiation of pericytes by inducing Wnt (zeige WNT2 Proteine)/beta-catenin signaling and T-cell factor-induced gene transcription.
cAMP/PKA regulation of GSK3beta/beta-catenin signaling contributes to the increase in progesterone production in corpus luteum.
Palmatin effect on osteoarthritis is likely mediated via the Wnt (zeige WNT2 Proteine)/beta-catenin and Hedgehog (zeige SHH Proteine) signaling
These results collectively showed that 2-Deoxy-D-glucose regulates dedifferentiation via beta-catenin pathway in rabbit articular chondrocytes.
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
catenin beta 1 subunit
, catenin beta-1
, beta catenin 1
, catenin (cadherin-associated protein), beta 1, 88kDa
, catenin beta-1-like
, catenin (cadherin associated protein), beta 1, 88kDa
, catenin beta
, beta catenin