Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Weitere Synonyme anzeigen
Wählen Sie die gewünschte Spezies
Human CTNNB1 Protein expressed in Wheat germ - ABIN1350670
Bian, Bai, Chapin, Le Moellic, Dong, Caplan, Sigworth, Navaratnam: Interactions between ?-catenin and the HSlo potassium channel regulates HSlo surface expression. in PLoS ONE 2011
Human CTNNB1 Protein expressed in Baculovirus infected Insect Cells - ABIN2004177
Hülsken, Birchmeier, Behrens: E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton. in The Journal of cell biology 1995
Show all 6 Pubmed References
temporal expression of CTNNB1 mRNA during dermal wound repair in the horse
Rspo3 (zeige RSPO3 Proteine)-LGR4 (zeige LGR4 Proteine) axis protects hepatocytes from hypoxia/reoxygenation injury via activating beta-catenin.
Modulation of beta-catenin levels or disruption of its cell adhesion role is correlated with aggressive tumorigenesis in basal ErbB2 (zeige ERBB2 Proteine)-driven mammary tumors with preexisting beta-catenin activation. Our data also emphasize the tumor suppressor role of beta-catenin, similar to other adherens junction proteins, in maintaining junctional integrity during tumor progression.
study uncovers a role for Pdpn (zeige PDPN Proteine) in mammary SC function and, importantly, identifies Pdpn (zeige PDPN Proteine) as a new regulator of Wnt (zeige WNT2 Proteine)/beta-catenin signaling, a key pathway in mammary development and tumorigenesis
CEACAM1 (zeige CEACAM1 Proteine) controls epithelial-mesenchymal transition in vitro and in vivo by site-specific regulation of beta-catenin phosphorylation
increased mesenchymal Wnt (zeige WNT2 Proteine) signaling inhibits the sequential formation of teeth, and suggest that Axin2 (zeige AXIN2 Proteine)/Runx2 (zeige RUNX2 Proteine) antagonistic interactions modulate the level of mesenchymal Wnt (zeige WNT2 Proteine)/beta-catenin signaling, underlying the contrasting dental phenotypes caused by human AXIN2 (zeige AXIN2 Proteine) and RUNX2 (zeige RUNX2 Proteine) mutations
beta-catenin (CTNNB1) maintains lung progenitors by promoting a hierarchical lung progenitor gene signature, suppressing gastrointestinal (GI) genes, and regulating NK2 homeobox 1 (NKX2.1 (zeige NKX2-1 Proteine)) and SRY box 2 (SOX2 (zeige SOX2 Proteine)) in a developmental stage-dependent manner.
findings provide the first line of evidence that links beta-catenin function to the cell proliferation and progenitor establishment during larynx and vocal fold development.
In mice that were separated from their mothers, cdh-1 is upregulated in the prefrontal cortex in both males and females. In addition, hippocampal CDH-1 mRNA levels were positively correlated with recognition memory performance in females. Maternal-separated reared male mice exhibited higher beta -Cat mRNA levels in the hippocampus.
PTEN-beta-catenin signaling is a novel regulator involved in modulating Treg development and may lead to a potential therapeutic target in liver ischemia/reperfusion injury
These results indicate that Wnt (zeige WNT2 Proteine)/beta-catenin signaling may play a key role in fibrotic scar formation after traumatic spinal cord injury.
The results demonstrate that the argon plasma jet (zeige FBXL15 Proteine) has no adverse effects on fin regeneration and embryogenesis in zebrafish, and does not interrupt the (Wnt (zeige WNT2 Proteine))/beta-Catenin-signaling pathways.
The expression of c-kit and beta-catenin suggests that erythropoietin (zeige EPO Proteine) may exert a role in regeneration reducing the extent of tubular damage from the outset after gentamicin administration.
Net1-regulated beta-catenin activation plays a crucial role in the dorsal axis formation during zebrafish development.
Wnt (zeige WNT2 Proteine)/beta-catenin signaling induces expression of col12a1a/b and deposition of Collagen XII, which is necessary for axons to actively navigate the non-neural lesion site environment.
Mechanistically, Hif-3alpha2 binds to beta-catenin and destabilizes the nuclear beta-catenin complex.
Nuclear beta-catenin is an indication of an activated Wnt (zeige WNT2 Proteine) pathway, therefore suggesting a possible role for Wnt (zeige WNT2 Proteine) signalling during zebrafish tooth development and replacement.
Findings suggest that microRNA 19b (miR (zeige MYLIP Proteine)-19b) regulates laterality development and heart looping in embryos by targeting beta-catenin ctnnb1.
Custos binds to beta-catenin in a Wnt (zeige WNT2 Proteine) responsive manner without affecting its stability, but rather modulates the cytoplasmic to nuclear translocation of beta-catenin.
The role of the beta-catenin mechanosensitive pathway in mesoderm identity has been conserved over the large evolutionary distance separating zebrafish and Drosophila.
The Wnt (zeige WNT2 Proteine)/beta-catenin signaling pathway establishes neuroanatomical asymmetries and their laterality. (Review)
We identified the amphibian leap2 (zeige LEAP2 Proteine) gene which is highly related to its mammalian orthologues at both structural and sequence levels. The gene is expressed in the embryo mostly in the endoderm-derived tissues. Accordingly it is induced in pluripotent animal cap cells by FGF, activin or a combination of vegT/beta-catenin.
Together, these results indicate that capsaicin inhibits the patterning of the dorso-ventral and anterior-posterior body axes of embryo by repressing PP2A (zeige PPP2R2B Proteine) and thereby down-regulating the Wnt (zeige WNT2 Proteine)/beta-catenin signaling.
maternal Wnt (zeige WNT2 Proteine)/STOP signaling, but not beta-catenin signaling, has a role in cleavage after fertilization and cell cycle progression
Wnt (zeige WNT2 Proteine) signalling can benefit from nucleo-cytoplasmic shuttling of APC (zeige APC Proteine), Axin (zeige AXIN1 Proteine) and GSK3, although they are in general beta-catenin antagonising proteins.
Phosphoinositide 3-kinase and Rac (zeige AKT1 Proteine) polarization depend specifically on the N-cadherin (zeige CDH2 Proteine)-p120 catenin (zeige CTNND1 Proteine) complex, whereas myosin II light chain and actin filament polarization depend on the N-cadherin (zeige CDH2 Proteine)-beta-catenin complex.
HERG (zeige KCNH2 Proteine) channel activity is stimulated by beta-catenin
Zic3 (zeige ZIC3 Proteine) can suppress Wnt (zeige WNT2 Proteine)/beta-catenin signaling and control development of the notochord and Spemann's organizer.
Notch initially destabilises beta-catenin in a process that does not depend on its phosphorylation by GSK3
The tyrosine kinase receptor (zeige KDR Proteine), PTK7 (zeige PTK7 Proteine), is implicated in beta-catenin-dependent developmental processes.
When considering endometrioid tumors of all grades and stages, CTNNB1 mutant tumors were associated with significantly higher rates of grades 1-2 disease, lower rates of deep myometrial invasion, and lower rates of lymphatic/vascular space invasion.
findings demonstrated that reduced membranous E-cadherin (zeige CDH1 Proteine) and aberrant beta-catenin expression were frequent events in SRCCs of various organs, and that the altered beta-catenin expression was significantly associated with advanced disease
Consistent with bioinformatics predictions, SOX7 (zeige SOX7 Proteine) was correlated positively with AXIN2 (zeige AXIN2 Proteine) and negatively with beta-catenin, suggesting that SOX7 (zeige SOX7 Proteine) and AXIN2 (zeige AXIN2 Proteine) might play important roles as co-regulators through the Wnt (zeige WNT2 Proteine)-beta-catenin pathway in the breast tissue to affect the carcinogenesis process.
application of dexamethasone reduced the expression of RUNX2 (zeige RUNX2 Proteine) and beta-catenin in human gingiva-derived mesenchymal stem cells
The lower apoptotic activity of low-grade slightly elevated adenomas can be partly attributed to upregulated beta-catenin pathway activity and downregulated c-Myc (zeige MYC Proteine) expression.
miR (zeige MLXIP Proteine)-330 inhibits IL-22 (zeige IL22 Proteine)-induced proliferation of HaCaT and HKC cell by targeting CTNNB1.
Overexpression of vPK led to reduced mRNA expression of cyclin D1 (zeige CCND1 Proteine), a well-known transcriptional product of Wnt (zeige WNT2 Proteine) signaling, suggesting that vPK effectively regulates the host signaling pathway through direct interactions with cellular proteins.
miR (zeige MLXIP Proteine)-218 promoted the apoptosis of human ovarian carcinoma cells via suppression of the WNT (zeige WNT2 Proteine)/beta-catenin signaling pathway.
Infection with bacterial AvrA-expressing Salmonella activates the STAT3 (zeige STAT3 Proteine) pathway, which induces the beta-catenin signals and enhances colonic tumorigenesis. (Review)
High CTNNB1 expression is associated with epithelial-mesenchymal transition in hepatocellular carcinoma.
Results highlight a potential role for the beta-catenin/Wnt (zeige WNT2 Proteine) and Notch (zeige NOTCH1 Proteine) signalling pathways during the infection of crypt cells by L. intracellularis.
Flutamide exposure led to decreased beta-catenin in corpus luteum of mid/late pregnancy.
beta-catenin signaling is involved in formation of contractile membranes by dedifferentiated retinal pigment epithelium cells.
Wnt3a (zeige WNT3A Proteine) produced a significant increase in heart valve interstitial cell number at day 4 and in the percentage of BrdU-positive nuclei at 24 h. The increase in proliferation was abolished by beta-catenin siRNA.
beta-catenin controls myocardin-related transcription factor-dependent transcription and emerges as a critical regulator of an array of cytoskeletal genes
beta-Catenin plays a critical role in mediating TGF-beta1 (zeige TGFB1 Proteine)-induced myofibroblast differentiation in aortic valve interstitial cells.
scratching-induced injury and repair of bronchial epithelial cells may involve inhibition of Glycogen synthase kinase 3beta activity which can lead to activation of the downstream signaling through beta-catenin
Data show that Wnt3a (zeige WNT3A Proteine) can inhibit the adipogenic differentiation of porcine AMSCs, and suggest that Wnt (zeige WNT2 Proteine)/beta-catenin signaling inhibits adipogenic differentiation potential and alters the cell fate from adipocytes to osteoblasts.
TNF-alpha (zeige TNF Proteine) inhibits adipogenesis through stabilization of beta-catenin protein in porcine preadipocytes.
Bovine herpesvirus 1 transiently increased beta-catenin protein levels in bovine kidney cells, but not in rabbit skin cells.
These results demonstrate that activation of AKT (zeige AKT1 Proteine) is required for gonadotropin regulation of CTNNB1 accumulation and subsequent ovarian E2 production.
beta-catenin, a transcription factor activated by the canonical Wnt signaling pathway, was frequently detected in bovine herpesvirus 1 ORF2-positive trigeminal ganglionic neurons of latently infected, but not mock-infected, calves.
These data demonstrate for the first time that FSH (zeige BRD2 Proteine) regulates CTNNB1 protein and WNT2 (zeige WNT2 Proteine) mRNA expressions in bovine granulosa cells, suggesting a potential role of canonical WNT (zeige WNT2 Proteine) signaling in ovarian steroidogenesis and follicular growth of cattle.
These data provide evidence that testosterone increases cellular beta-catenin content which promotes the expression of beta-catenin-targeted genes and myogenesis in the muscle-derived stem cells of cattle.
that beta-catenin is a plasma membrane-associated protein (zeige PDZK1IP1 Proteine) in airway smooth muscle that regulates active tension development, presumably by stabilizing cell-cell contacts and thereby supporting force transmission between neighboring cells.
This study demonstrated a relationship between the timing of the development of in vitro-produced bovine embryos and the distribution and localization of the junction protein beta-catenin.
TGF-beta3 (zeige TGFB3 Proteine) induces the chondrogenic differentiation of pericytes by inducing Wnt (zeige WNT2 Proteine)/beta-catenin signaling and T-cell factor-induced gene transcription.
cAMP/PKA regulation of GSK3beta/beta-catenin signaling contributes to the increase in progesterone production in corpus luteum.
Palmatin effect on osteoarthritis is likely mediated via the Wnt (zeige WNT2 Proteine)/beta-catenin and Hedgehog (zeige SHH Proteine) signaling
These results collectively showed that 2-Deoxy-D-glucose regulates dedifferentiation via beta-catenin pathway in rabbit articular chondrocytes.
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
catenin beta 1 subunit
, catenin beta-1
, beta catenin 1
, catenin (cadherin-associated protein), beta 1, 88kDa
, catenin beta-1-like
, catenin (cadherin associated protein), beta 1, 88kDa
, catenin beta
, beta catenin