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Human CTNNB1 Protein expressed in Wheat germ - ABIN1350670
Bian, Bai, Chapin, Le Moellic, Dong, Caplan, Sigworth, Navaratnam: Interactions between ?-catenin and the HSlo potassium channel regulates HSlo surface expression. in PLoS ONE 2011
Human CTNNB1 Protein expressed in Baculovirus infected Insect Cells - ABIN2004177
Hülsken, Birchmeier, Behrens: E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton. in The Journal of cell biology 1995
Show all 6 Pubmed References
temporal expression of CTNNB1 mRNA during dermal wound repair in the horse
These results indicate that Wnt (zeige WNT2 Proteine)/beta-catenin signaling may play a key role in fibrotic scar formation after traumatic spinal cord injury.
Data show that phospholipase C (PLC (zeige PLC Proteine))-beta1 (PLC (zeige HSPG2 Proteine)-beta1) overexpression determines an increase in beta-catenin translocation and that PLC (zeige HSPG2 Proteine)-beta1, inositol polyphosphate multikinase (IPMK (zeige IPMK Proteine)) and beta-catenin are mediators of the same signaling pathway.
FGF23 (zeige FGF23 Proteine) promotes myocardial fibrosis and exacerbates diastolic dysfunction induced by myocardial infarction or ischemia/reperfusion , which is associated with the upregulation of active beta-catenin and TGF-beta (zeige TGFB1 Proteine)
Suggest that Pygo2 has a tumor promoting function related to Wnt/ss-catenin signaling activity during intestinal tumor initiation and progression.
Data suggest that Wnt (zeige WNT2 Proteine) signaling directs fatty acid metabolism via canonical mechanism involving activation of beta-catenin in osteoblasts; beta-catenin accumulation and activation are required for normal lipid catabolism in osteoblasts and white adipose tissue.
Stretch induced p120 (zeige CTNND1 Proteine) degradation and the endocytosis of E-cadherin (zeige CDH1 Proteine), which induced beta-catenin translocation into the nucleus, a key event in lung injury progress and repair.
Expression of a dominant stable form of beta-catenin in hepatocytes results in severe cholestasis and biliary type fibrosis.
These data suggested that Wnt (zeige WNT2 Proteine)/beta-catenin pathway might be a potential target to treat the LPS (zeige TLR4 Proteine)-induced inflammation in ALI.
Data show that Wnt (zeige WNT2 Proteine) beta-Catenin signaling pathway activation followed by Notch (zeige NOTCH1 Proteine) inhibition strongly promotes the mitotic regeneration of new hair cell (HC) in both normal and neomycin-damaged cochleae.
KY1022, a small molecule that destabilizes both beta-catenin and Ras by targeting the Wnt (zeige WNT2 Proteine)/beta-catenin pathway, inhibitits cellular events, including epithelial mesenchymal transformation, an initial process of metastasis, and apoptosis in colorectal cancer cells.
The expression of c-kit and beta-catenin suggests that erythropoietin (zeige EPO Proteine) may exert a role in regeneration reducing the extent of tubular damage from the outset after gentamicin administration.
Net1-regulated beta-catenin activation plays a crucial role in the dorsal axis formation during zebrafish development.
Wnt (zeige WNT2 Proteine)/beta-catenin signaling induces expression of col12a1a/b and deposition of Collagen XII, which is necessary for axons to actively navigate the non-neural lesion site environment.
Mechanistically, Hif-3alpha2 binds to beta-catenin and destabilizes the nuclear beta-catenin complex.
Nuclear beta-catenin is an indication of an activated Wnt (zeige WNT2 Proteine) pathway, therefore suggesting a possible role for Wnt (zeige WNT2 Proteine) signalling during zebrafish tooth development and replacement.
Findings suggest that microRNA 19b (miR (zeige MYLIP Proteine)-19b) regulates laterality development and heart looping in embryos by targeting beta-catenin ctnnb1.
Custos binds to beta-catenin in a Wnt (zeige WNT2 Proteine) responsive manner without affecting its stability, but rather modulates the cytoplasmic to nuclear translocation of beta-catenin.
The role of the beta-catenin mechanosensitive pathway in mesoderm identity has been conserved over the large evolutionary distance separating zebrafish and Drosophila.
The Wnt (zeige WNT2 Proteine)/beta-catenin signaling pathway establishes neuroanatomical asymmetries and their laterality. (Review)
This study demonstrated that beta-catenin/Wnt (zeige WNT2 Proteine) signaling is initially required to activate cell-cycle re-entry in Muller glia following injury and that Wnt (zeige WNT2 Proteine) signaling subsequently controls the fate of the progeny of those cell divisions.
We identified the amphibian leap2 (zeige LEAP2 Proteine) gene which is highly related to its mammalian orthologues at both structural and sequence levels. The gene is expressed in the embryo mostly in the endoderm-derived tissues. Accordingly it is induced in pluripotent animal cap cells by FGF, activin or a combination of vegT/beta-catenin.
Together, these results indicate that capsaicin inhibits the patterning of the dorso-ventral and anterior-posterior body axes of embryo by repressing PP2A (zeige PPP2R2B Proteine) and thereby down-regulating the Wnt (zeige WNT2 Proteine)/beta-catenin signaling.
maternal Wnt (zeige WNT2 Proteine)/STOP signaling, but not beta-catenin signaling, has a role in cleavage after fertilization and cell cycle progression
Wnt (zeige WNT2 Proteine) signalling can benefit from nucleo-cytoplasmic shuttling of APC (zeige APC Proteine), Axin (zeige AXIN1 Proteine) and GSK3, although they are in general beta-catenin antagonising proteins.
Phosphoinositide 3-kinase and Rac (zeige AKT1 Proteine) polarization depend specifically on the N-cadherin (zeige CDH2 Proteine)-p120 catenin (zeige CTNND1 Proteine) complex, whereas myosin II light chain and actin filament polarization depend on the N-cadherin (zeige CDH2 Proteine)-beta-catenin complex.
HERG (zeige KCNH2 Proteine) channel activity is stimulated by beta-catenin
Zic3 (zeige ZIC3 Proteine) can suppress Wnt (zeige WNT2 Proteine)/beta-catenin signaling and control development of the notochord and Spemann's organizer.
Notch initially destabilises beta-catenin in a process that does not depend on its phosphorylation by GSK3
The tyrosine kinase receptor (zeige KDR Proteine), PTK7 (zeige PTK7 Proteine), is implicated in beta-catenin-dependent developmental processes.
Infection with bacterial AvrA-expressing Salmonella activates the STAT3 (zeige STAT3 Proteine) pathway, which induces the beta-catenin signals and enhances colonic tumorigenesis. (Review)
High CTNNB1 expression is associated with epithelial-mesenchymal transition in hepatocellular carcinoma.
Therefore, our study demonstrates that miR (zeige MLXIP Proteine)-183 is a tumor suppressor microRNA that plays a major role in OS.
Suppression of AXL by shRNA and inhibitor prolonged survival of chronic myelogenous leukemia (CML) mice and reduced the growth of leukemia stem cells ( LSCs) in mice. Gas6/AXL ligation stabilizes beta-catenin in an AKT-dependent fashion in human CML CD34(+) cells. Our findings improve the understanding of LSC regulation and validate Gas6/AXL as a pair of therapeutic targets to eliminate CML LSCs
This beta-catenin-mediated activation of PHB (zeige PHB Proteine) expression was independent of cMYC (zeige MYC Proteine) activation, a product of Wnt (zeige WNT2 Proteine) signaling.These data indicate that PHB (zeige PHB Proteine) is a direct target of beta-catenin and the increased level of PHB (zeige PHB Proteine) in leukemia can be regulated by Wnt (zeige WNT2 Proteine) signaling
Silencing p65 (zeige GORASP1 Proteine) attenuates FOXM1 (zeige FOXM1 Proteine) and beta-catenin expression. NF-kappaB (zeige NFKB1 Proteine) activation is required for nuclear translocation of FOXM1 (zeige FOXM1 Proteine) and beta-catenin. FOXM1 (zeige FOXM1 Proteine) and beta-catenin positively regulate NF-kappaB.Knockdown of beta-catenin and FOXM1 (zeige FOXM1 Proteine) downregulates p65 (zeige GORASP1 Proteine) protein and NF-kappaB (zeige NFKB1 Proteine)-dependent reporter activity.
this study showed that Annexin A2 (zeige ANXA2 Proteine) inhibition suppresses proliferation and invasion in ovarian cancer via beta-catenin/EMT (zeige ITK Proteine), proposing the potential role of Annexin A2 (zeige ANXA2 Proteine) in the prevention and treatment of ovarian cancer
Kindlin-2 (zeige FERMT2 Proteine) is up-regulated in glioma cells and acts as an oncogene (zeige RAB1A Proteine). It is an independent risk factor for poor prognosis. The Kindlin-2 (zeige FERMT2 Proteine)/YB-1 (zeige YBX1 Proteine)/beta-catenin complex promotes EGFR (zeige EGFR Proteine) transcription and contributes to glioma progression. Kindlin-2 (zeige FERMT2 Proteine) is a potential diagnostic and prognostic marker in glioma, and inhibition of Kindlin-2 (zeige FERMT2 Proteine) may be a novel strategy for glioma treatment.
USP9X (zeige USP9X Proteine) stabilizes beta-catenin and activates Wnt (zeige WNT2 Proteine)/beta-catenin signal pathway to promote glioma cell proliferation and survival.
WM130 preferentially inhibits hepatic cancer stem-like cells by suppressing AKT (zeige AKT1 Proteine)/GSK3beta/beta-catenin signaling pathway.
Results highlight a potential role for the beta-catenin/Wnt (zeige WNT2 Proteine) and Notch (zeige NOTCH1 Proteine) signalling pathways during the infection of crypt cells by L. intracellularis.
Flutamide exposure led to decreased beta-catenin in corpus luteum of mid/late pregnancy.
beta-catenin signaling is involved in formation of contractile membranes by dedifferentiated retinal pigment epithelium cells.
Wnt3a (zeige WNT3A Proteine) produced a significant increase in heart valve interstitial cell number at day 4 and in the percentage of BrdU-positive nuclei at 24 h. The increase in proliferation was abolished by beta-catenin siRNA.
beta-catenin controls myocardin-related transcription factor-dependent transcription and emerges as a critical regulator of an array of cytoskeletal genes
beta-Catenin plays a critical role in mediating TGF-beta1 (zeige TGFB1 Proteine)-induced myofibroblast differentiation in aortic valve interstitial cells.
scratching-induced injury and repair of bronchial epithelial cells may involve inhibition of Glycogen synthase kinase 3beta activity which can lead to activation of the downstream signaling through beta-catenin
Data show that Wnt3a (zeige WNT3A Proteine) can inhibit the adipogenic differentiation of porcine AMSCs, and suggest that Wnt (zeige WNT2 Proteine)/beta-catenin signaling inhibits adipogenic differentiation potential and alters the cell fate from adipocytes to osteoblasts.
TNF-alpha (zeige TNF Proteine) inhibits adipogenesis through stabilization of beta-catenin protein in porcine preadipocytes.
Bovine herpesvirus 1 transiently increased beta-catenin protein levels in bovine kidney cells, but not in rabbit skin cells.
These results demonstrate that activation of AKT (zeige AKT1 Proteine) is required for gonadotropin regulation of CTNNB1 accumulation and subsequent ovarian E2 production.
beta-catenin, a transcription factor activated by the canonical Wnt signaling pathway, was frequently detected in bovine herpesvirus 1 ORF2-positive trigeminal ganglionic neurons of latently infected, but not mock-infected, calves.
These data demonstrate for the first time that FSH (zeige BRD2 Proteine) regulates CTNNB1 protein and WNT2 (zeige WNT2 Proteine) mRNA expressions in bovine granulosa cells, suggesting a potential role of canonical WNT (zeige WNT2 Proteine) signaling in ovarian steroidogenesis and follicular growth of cattle.
These data provide evidence that testosterone increases cellular beta-catenin content which promotes the expression of beta-catenin-targeted genes and myogenesis in the muscle-derived stem cells of cattle.
that beta-catenin is a plasma membrane-associated protein (zeige PDZK1IP1 Proteine) in airway smooth muscle that regulates active tension development, presumably by stabilizing cell-cell contacts and thereby supporting force transmission between neighboring cells.
This study demonstrated a relationship between the timing of the development of in vitro-produced bovine embryos and the distribution and localization of the junction protein beta-catenin.
TGF-beta3 (zeige TGFB3 Proteine) induces the chondrogenic differentiation of pericytes by inducing Wnt (zeige WNT2 Proteine)/beta-catenin signaling and T-cell factor-induced gene transcription.
cAMP/PKA regulation of GSK3beta/beta-catenin signaling contributes to the increase in progesterone production in corpus luteum.
Palmatin effect on osteoarthritis is likely mediated via the Wnt (zeige WNT2 Proteine)/beta-catenin and Hedgehog (zeige SHH Proteine) signaling
These results collectively showed that 2-Deoxy-D-glucose regulates dedifferentiation via beta-catenin pathway in rabbit articular chondrocytes.
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
catenin beta 1 subunit
, catenin beta-1
, beta catenin 1
, catenin (cadherin-associated protein), beta 1, 88kDa
, catenin beta-1-like
, catenin (cadherin associated protein), beta 1, 88kDa
, catenin beta
, beta catenin