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Human CTNNB1 Protein expressed in Baculovirus infected Insect Cells - ABIN2004177
Hülsken, Birchmeier, Behrens: E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton. in The Journal of cell biology 1995
Show all 6 Pubmed References
Human CTNNB1 Protein expressed in Wheat germ - ABIN1350670
Bian, Bai, Chapin, Le Moellic, Dong, Caplan, Sigworth, Navaratnam: Interactions between ?-catenin and the HSlo potassium channel regulates HSlo surface expression. in PLoS ONE 2011
significantly increased gene expression in early osteochondrosis osteochondral junction chondrocytes compared to controls
temporal expression of CTNNB1 mRNA during dermal wound repair in the horse
Data indicate a function of GATA binding protein 4 (GATA4) as a cardiac repressor of the transcription factor 7-like 2 protein (TCF7L2)/beta-catenin complex.
Bioinformatic analysis of the protein networks implies potentially novel functions for beta-catenin, particularly in mRNA translation, and we confirm a direct interaction between beta-catenin and the fragile X mental retardation protein (FMRP).
Ablation of beta-catenin resulted in STAT3 downregulation and STAT1 activation, leading to elevated macrophage inflammatory responses and increased atherosclerosis in Ldl receptor deficient mice.
This study show that beta-catenin in excitatory neurons of the adult neocortex is essential for the optimal processing of visual information.
nuclear organization of motor neurons is dependent on inside-out positioning, orchestrated by N-cadherin, catenin, and afadin activities, controlling cell body layering on the medio-lateral axis.
these indicate that SLIT3/ROBO2 promotes chondrocyte maturation via the inhibition of beta-catenin signaling.
mechanical unloading decreases MACF1 expression, and MACF1 up-regulates osteoblast proliferation through enhancing beta-catenin signaling. This study has thus provided a mechanism for mechanical unloading-induced inhibited osteoblast proliferation.
beta-catenin, which acts as a positive regulator of osteogenic differentiation, was negatively regulated by miR-92a1-5p.
we identified beta-catenin as a central player in maintaining Treg function and regulating the production of both IFN-gamma and IL-10 cytokines
TP53INP2 modulates adipogenesis through autophagy-dependent sequestration of GSK3beta into late endosomes and beta catenin activation, regulating adiposity.
The association of specific modifications of beta-catenin during normal lung development and again in response to lung injury supports the widely held concept that repair of lung injury involves the recapitulation of developmental programs.
beta-catenin inactivation in GLAST-expressing cells enhanced anxious/depressive-like responses.
Gfi1b regulates the level of Wnt3a/beta-catenin signaling in hematopoietic stem cells and megakaryocytes.
variations in Wnt/Beta-catenin signaling activity contribute to the severity of the osteochondroma phenotype by affecting both, osteochondroma size and number, in distinct manners.
This is the first demonstration of a reciprocal interaction between beta-catenin and Osx and the first report to show that a pathway downstream of Osx that signals through Tcf/Lefs is critical for cementogenesis during tooth development.
Intriguingly, Wnt3a, a Wnt/beta-catenin signalling ligand, significantly inhibited Mycobacterium bovis Bacillus Calmette-Guerin (BCG)-induced autophagy, with decreased autophagy rates and autophagic flux.
Major findings of the last decade document that Wnt/beta-catenin signaling in partnership with glial cells is critically involved in each step and at every level in the regulation of nigrostriatal dopaminergic neuronal health, protection, and regeneration in in the MPTP mouse model of Parkinson's disease. (Review)
It has been shown that the Wnt3a/beta-catenin/BDNF axis in the spinal neural circuit plays an important role in regulating capsaicin-induced pain.
mitochondria support osteoblast differentiation by promoting beta-catenin acetylation and activity
High CTNNB1 expression is associated with kidney fibrosis.
Studied apoptosis and the Wnt/beta-catenin pathway in the cases of bisphenol A (BPA) and di(2-ethylhexyl) phthalate (DEHP) exposure in zebrafish embryos.
Wnt/beta-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling in the process of neovascularization of the central nervous system and blood-brain barrier formation.
The results demonstrate that the argon plasma jet has no adverse effects on fin regeneration and embryogenesis in zebrafish, and does not interrupt the (Wnt)/beta-Catenin-signaling pathways.
The expression of c-kit and beta-catenin suggests that erythropoietin may exert a role in regeneration reducing the extent of tubular damage from the outset after gentamicin administration.
Net1-regulated beta-catenin activation plays a crucial role in the dorsal axis formation during zebrafish development.
Wnt/beta-catenin signaling induces expression of col12a1a/b and deposition of Collagen XII, which is necessary for axons to actively navigate the non-neural lesion site environment.
Mechanistically, Hif-3alpha2 binds to beta-catenin and destabilizes the nuclear beta-catenin complex.
Nuclear beta-catenin is an indication of an activated Wnt pathway, therefore suggesting a possible role for Wnt signalling during zebrafish tooth development and replacement.
Findings suggest that microRNA 19b (miR-19b) regulates laterality development and heart looping in embryos by targeting beta-catenin ctnnb1.
Custos binds to beta-catenin in a Wnt responsive manner without affecting its stability, but rather modulates the cytoplasmic to nuclear translocation of beta-catenin.
The role of the beta-catenin mechanosensitive pathway in mesoderm identity has been conserved over the large evolutionary distance separating zebrafish and Drosophila.
The Wnt/beta-catenin signaling pathway establishes neuroanatomical asymmetries and their laterality. (Review)
This study demonstrated that beta-catenin/Wnt signaling is initially required to activate cell-cycle re-entry in Muller glia following injury and that Wnt signaling subsequently controls the fate of the progeny of those cell divisions.
A novel role for Eaf1 and Eaf2 in inhibiting canonical Wnt/beta-catenin signaling, which might form the mechanistic basis for Eaf1 and Eaf2 tumor suppressor activity.
Ccr7 functions during axis formation as a GPCR to inhibit beta-catenin, likely by promoting Ca(2+) transients throughout the blastula.
ctnnb1 and ctnnb2 regulate multiple processes of laterality development in zebrafish embryos through similar and distinct mechanisms.
2-OST functions within the Wnt pathway, downstream of Wnt ligand signaling and upstream of Gsk3beta and beta-catenin intracellular localization and function
It was shown that Wnt3a-Wnt8a/beta-catenin signaling directly regulates ciliogenic transcription factor foxj1a expression and ciliogenesis in zebrafish Kupffer's vesicle.
A Disc1 peptide binds to GSK3beta, and Disc1 directs early brain development and neurogenesis, by promoting beta-catenin-mediated Wnt signaling and inhibiting GSK3beta activity.
Foxo3b played a very important role in embryogenesis and negatively regulated maternal and zygotic Wnt/beta-catenin signaling by directly interacting with both beta-catenin1 and beta-catenin2.
We identified the amphibian leap2 gene which is highly related to its mammalian orthologues at both structural and sequence levels. The gene is expressed in the embryo mostly in the endoderm-derived tissues. Accordingly it is induced in pluripotent animal cap cells by FGF, activin or a combination of vegT/beta-catenin.
Together, these results indicate that capsaicin inhibits the patterning of the dorso-ventral and anterior-posterior body axes of embryo by repressing PP2A and thereby down-regulating the Wnt/beta-catenin signaling.
maternal Wnt/STOP signaling, but not beta-catenin signaling, has a role in cleavage after fertilization and cell cycle progression
Wnt signalling can benefit from nucleo-cytoplasmic shuttling of APC, Axin and GSK3, although they are in general beta-catenin antagonising proteins.
Phosphoinositide 3-kinase and Rac polarization depend specifically on the N-cadherin-p120 catenin complex, whereas myosin II light chain and actin filament polarization depend on the N-cadherin-beta-catenin complex.
HERG channel activity is stimulated by beta-catenin
Zic3 can suppress Wnt/beta-catenin signaling and control development of the notochord and Spemann's organizer.
Notch initially destabilises beta-catenin in a process that does not depend on its phosphorylation by GSK3
The tyrosine kinase receptor, PTK7, is implicated in beta-catenin-dependent developmental processes.
Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP, and modulates RhoA activity.
Activated Xenopus CTNNB1 regulates embryonic limb development via FGF signaling
data demonstrate a positive role for protein phosphatase 2A:B56epsilon in the Wnt/beta-catenin signaling pathway
Data support a mechanism in which maternal XSOX3 inhibits beta-catenin-mediated axis specification by repressing expression of Xnr5.
Chordin, Noggin, beta-Catenin, and Cerberus have roles in neural induction in Xenopus
Sox17 and beta-catenin interact to transcribe endodermal target genes
The localized activation of Wnt/beta-catenin signaling, which converts Tcf from a repressor to an activator, is required for the establishment of dorsal-ventral patterning in the prospective diencephalon.
Expression of Btg-x protein is regulated by both beta-Catenin and Nodal-related signals.
High activity of beta catenin led to efficient cell sorting from the notochord to the somites, whereas reduced activity led to sorting in the opposite direction.
Tcf/Lef genes encode factors of different activities, which function together in antagonistic or synergistic ways to modulate the intensity and outcome of Wnt/beta-catenin signalling and to trigger tissue-specific responses.
MiR-142-3p functions as a tumor suppressor in NSCLC progression through inhibiting MALAT1/beta-catenin signaling.
CTNNB1 3'-UTR variant rs2953 is associated with schizophrenia risk. rs2953 disrupted the binding of CTNNB1 and miR-485.
over-expression of miR-638 inhibited the activation of Wnt/beta-catenin signaling pathway.
In this case-control study, we found that cases of recurrent stage I, grade 1 endometrioid endometrial cancer had a significantly higher rate of CTNNB1 mutation and microsatellite stability than matched non-recurrent controls.
Study found that lncTIC1 is highly expressed in liver tumor-initiating cells (TICs) and required for the self-renewal of liver TICs. LncTIC1 drove liver TIC self-renewal through Wnt/beta-catenin signaling. LncTIC1 interacted with the N terminal of beta-catenin and inhibited the phosphorylation of beta-catenin, finally maintaining the stability of beta-catenin to drive the activation of Wnt/beta-catenin signaling and li...
UCH37 maintains the homeostasis of proteasomal degradation reciprocally by assisting the recruitment of the ubiquitin receptor Rpn13 into the proteasome and by reversing ubiquitination of certain critical substrates of the 26 S proteasome.
nuclear localization of beta-catenin assessed by immunohistochemistry does not detect all endometrial cancers with CTNNB1 gene mutation
The decreased hepatic expression of IRS1 and beta-catenin in nonalcoholic fatty liver disease is linked to histological progression such as ballooning, and might lead to diabetes as a result of impaired glucose metabolism.
These mutations increased binding of FLNB protein to the MAP3K1 and RAC1 signal transduction complex and activated beta-catenin and had different effects on phosphorylation of MAP kinase pathway intermediates and SOX9 expression. Direct activation of beta-catenin through the FLNB-MAP3K1-RAC1 complex by FLNB mutations is a novel mechanism for causing 46,XY gonadal dysgenesis
circular RNA derived from the beta-catenin gene locus is highly expressed in liver cancer tissues and affects a wide spectrum of Wnt pathway-related genes
FEZF1-AS1 might be a key regulator of cell cycle, EMT and Wnt/beta-catenin signaling in NPC cells.
TIMP-1 plays a negative regulatory role in the proliferation and osteogenesis of hBMSCs, at least partially, through Wnt/beta-catenin signaling.
Serum beta-catenin levels are correlated with necroinflammation parameters but not with viral load.
The coregulation of beta-catenin and RAS stabilities by the modulation of their interaction provides a mechanism for Wnt/beta-catenin and RAS-ERK pathway cross-talk and the synergistic transformation of colorectal cancer by both APC and KRAS mutations.
High CTNNB1 expression is associated with invasive breast carcinoma.
Results show that Akt1-deficient endothelial cells exhibited increased phosphorylation and nuclear translocation of phosphorylated beta-catenin.
These findings provide new insights into a mechanism of miR-152 involved in beta-catenin and PKM2 inhibition.
We further confirmed absence of Sox9 expression in nuclear beta-catenin accumulating cells of adamantinomatous craniopharyngioma. Our results point to the conclusion that Sox2 and Sox9, seem to play essential roles not only in the specific formation of aCP, but also in processes involving the cerebral tumour environment, which needs to be illuminated in the future.
this study shows that thyroid hormone promotes beta-catenin activation and cell proliferation in colorectal cancer
In this study, animal experimentation verified that the canonical Wnt/beta-catenin signaling pathway was activated under a reduced activity of p-beta-catenin (Ser33/37/Thr41) and an increased accumulation of beta-catenin in the lungs and kidneys of pigs infected with a highly virulent strain of Haemophilus parasuis.
Results highlight a potential role for the beta-catenin/Wnt and Notch signalling pathways during the infection of crypt cells by L. intracellularis.
Flutamide exposure led to decreased beta-catenin in corpus luteum of mid/late pregnancy.
beta-catenin signaling is involved in formation of contractile membranes by dedifferentiated retinal pigment epithelium cells.
Wnt3a produced a significant increase in heart valve interstitial cell number at day 4 and in the percentage of BrdU-positive nuclei at 24 h. The increase in proliferation was abolished by beta-catenin siRNA.
This study tested whether prenatal and neonatal exposure to antiandrogen flutamide affected ovarian 17beta-estradiol synthesis and the associated gene expression in large antral follicles of adult pigs.
beta-catenin controls myocardin-related transcription factor-dependent transcription and emerges as a critical regulator of an array of cytoskeletal genes
beta-Catenin plays a critical role in mediating TGF-beta1-induced myofibroblast differentiation in aortic valve interstitial cells.
scratching-induced injury and repair of bronchial epithelial cells may involve inhibition of Glycogen synthase kinase 3beta activity which can lead to activation of the downstream signaling through beta-catenin
Data show that Wnt3a can inhibit the adipogenic differentiation of porcine AMSCs, and suggest that Wnt/beta-catenin signaling inhibits adipogenic differentiation potential and alters the cell fate from adipocytes to osteoblasts.
TNF-alpha inhibits adipogenesis through stabilization of beta-catenin protein in porcine preadipocytes.
Bovine herpesvirus 1 transiently increased beta-catenin protein levels in bovine kidney cells, but not in rabbit skin cells.
These results demonstrate that activation of AKT is required for gonadotropin regulation of CTNNB1 accumulation and subsequent ovarian E2 production.
beta-catenin, a transcription factor activated by the canonical Wnt signaling pathway, was frequently detected in bovine herpesvirus 1 ORF2-positive trigeminal ganglionic neurons of latently infected, but not mock-infected, calves.
These data demonstrate for the first time that FSH regulates CTNNB1 protein and WNT2 mRNA expressions in bovine granulosa cells, suggesting a potential role of canonical WNT signaling in ovarian steroidogenesis and follicular growth of cattle.
These data provide evidence that testosterone increases cellular beta-catenin content which promotes the expression of beta-catenin-targeted genes and myogenesis in the muscle-derived stem cells of cattle.
that beta-catenin is a plasma membrane-associated protein in airway smooth muscle that regulates active tension development, presumably by stabilizing cell-cell contacts and thereby supporting force transmission between neighboring cells.
This study demonstrated a relationship between the timing of the development of in vitro-produced bovine embryos and the distribution and localization of the junction protein beta-catenin.
TGF-beta3 induces the chondrogenic differentiation of pericytes by inducing Wnt/beta-catenin signaling and T-cell factor-induced gene transcription.
cAMP/PKA regulation of GSK3beta/beta-catenin signaling contributes to the increase in progesterone production in corpus luteum.
Palmatin effect on osteoarthritis is likely mediated via the Wnt/beta-catenin and Hedgehog signaling
These results collectively showed that 2-Deoxy-D-glucose regulates dedifferentiation via beta-catenin pathway in rabbit articular chondrocytes.
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
catenin beta 1 subunit
, catenin beta-1
, beta catenin 1
, catenin (cadherin-associated protein), beta 1, 88kDa
, catenin beta-1-like
, catenin (cadherin associated protein), beta 1, 88kDa
, catenin beta
, beta catenin