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Results show that missense mutations exert dominant negative effects on the keratins K1/K10 (zeige KRT10 Proteine) protein structure by altering inter-chain interactions.
casein kinase 1 phosphorylates the SQSTM1 (zeige SQSTM1 Proteine) S349 residue when harmful proteins accumulate under HSF1 (zeige HSF1 Proteine) stress
Maintenance of the progenitors thus requires cooperation by PRMT1 (zeige PRMT1 Proteine) and CSNK1a1 to sustain proliferation gene expression and suppress premature differentiation driven by GRHL3 (zeige GRHL3 Proteine)
These data indicate that CK1alpha has a dominant and non-redundant function in melanoma cells
KRT1 and the specific polymorphism of KRT1 in this Chinese Han population are associated with autoimmune diseases SLE and SSc (zeige CYP11A1 Proteine)
Disruption of CK1alpha function in myeloma cells resulted in decreased Mdm2 (zeige MDM2 Proteine), increased p53 (zeige TP53 Proteine) and p21 (zeige CDKN1A Proteine) and reduced expression of beta-catenin (zeige CTNNB1 Proteine) and AKT (zeige AKT1 Proteine).
CK1delta enhances EPO (zeige EPO Proteine) secretion from liver cancer cells under hypoxia by modifying HIF-2alpha (zeige EPAS1 Proteine) and promoting its nuclear accumulation.
CKIalpha-mediated NS5A S235 phosphorylation is critical for HCV replication. CaMKII (zeige CAMK2G Proteine) gamma and delta may have negative roles in the HCV life cycle.
Case Report: post-zygotic mosaicism of KRT/1o mutations in epidermolytic Ichthyosis (zeige LBR Proteine).
KRT1 played an important role of maintaining epithelial barrier and its down-regulation in intestinal tissue was correlated with the progression of inflammatory bowel disease.
Interactome analyses revealed that the Jade-1S mutant unable to be phosphorylated by CK1alpha has an increased binding affinity to proteins involved in chromatin remodelling, histone deacetylation, transcriptional repression, and ribosome biogenesis.
Phosphorylation of LRRK2 by casein kinase 1alpha regulates trans-Golgi clustering via differential interaction with ARHGEF7 (zeige ARHGEF7 Proteine).
Phosphorylation of FADD (zeige FADD Proteine) by the kinase CK1alpha promotes KRASG12D-induced lung cancer.
Csnk1a1 knockdown results in decreased Rps6 (zeige RPS6 Proteine) phosphorylation, increased p53 (zeige TP53 Proteine) activity, and myeloid differentiation.
study for the first time demonstrates that CK1alpha is required for chromosome alignment and segregation during oocyte meiotic maturation and early embryo development
Silencing or deleting the p53 (zeige TP53 Proteine) gene demonstrated that genotoxic stress elicited Wnt (zeige WNT2 Proteine) signaling in a p53 (zeige TP53 Proteine)-independent manner. Instead, this response occurred through reduced abundance of Csnk1a1 (CK1alpha), a kinase that inhibits beta-catenin (zeige CTNNB1 Proteine).
maintenance of intestinal homeostasis in CKIalpha-deficient gut (zeige GUSB Proteine) requires p53 (zeige TP53 Proteine)-mediated growth control, because the combined ablation of Csnk1a1 and either p53 (zeige TP53 Proteine) or its target gene p21 triggered high-grade dysplasia with extensive proliferation
Casein kinase I (zeige CSNK1D Proteine) and casein kinase II (zeige CSNK2A1 Proteine) differentially regulate axin (zeige AXIN1 Proteine) function
CK1alpha-mediated phosphorylation modulates the mRNA binding ability of hnRNP-C
CK1 regulates fast synaptic transmission by glutamate (zeige GRIN1 Proteine) in brain. Activation of CK1 decreases NMDA receptor activity in the striatum via activation by this kinase of protein phosphatase 1 (zeige PPP1CB Proteine) &/or 2A & increased dephosphorylation of NMDA receptors.
Here, we report that in response to factors that promote cell motility, the Rap guanine exchange factor RAPGEF2 is rapidly phosphorylated by I-kappa-B-kinase-beta and casein kinase-1alpha and consequently degraded by the proteasome.
The phosphorylation of p53 (zeige TP53 Proteine) by CK1 is an isoform-specific reaction to the K(221)RQK(224) loop.
data provide a molecular insight into the structural features that underlie the site specificity of CK1a
we identify Casein Kinase I alpha (CK1alpha) as an additional negative-regulator of Cap-H2. CK1a-depletion stabilizes Cap-H2 protein and results in an accumulation of Cap-H2 on chromosomes.
Expected genes in the Scar-Arp2 (zeige ACTR2 Proteine)/3 actin (zeige ACTB Proteine) nucleation pathway were identified as well as casein kinase I, which had a similar morphological RNAi signature.
CKI(Casein kinase I) functions as a negative regulator of Arm protein, by phosphorylating it on Ser (zeige SIGLEC1 Proteine) and Thr (zeige TRH Proteine) residues in the N-terminus and targeting it for degradation.
2 proteins reported to function in Wingless(Wg) signaling identified as Hh pathway components: Dally-like protein required for Hh signal reception, and casein kinase 1alpha, a candidate tumor suppressor that regulates activities of both Hh and Wg pathways
expression of doubletime in Drosophila S2 cells produced a CKI-7-sensitive kinase activity which was reduced by both the dbt(S) and dbt(L) mutations of circadian rhythm
doubletime and CKII (zeige CSNK2A1 Proteine) kinases collaborate to potentiate Drosophila PER transcriptional repressor activity
Several CKI isoforms including CKIalpha and Gish/CKIgamma can phosphorylate the Wg coreceptor Arrow (Arr), which may account, at least in part, for their positive roles in the Wg pathway.
Mutation of ck1alpha or -epsilon or sgg/gsk3beta in wing imaginal discs results in the accumulation of dMyc protein, suggesting a physiological role for these kinases in vivo.
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
, casein kinase I isoform alpha
, clock regulator kinase
, down-regulated in lung cancer
, 67 kDa cytokeratin
, cytokeratin 1
, epidermolytic hyperkeratosis 1
, hair alpha protein
, keratin, type II cytoskeletal 1
, type-II keratin Kb1
, casein kinase I-alpha
, casein kinase I alpha LS
, protein kinase CK1 (casein kinase 1) isoform alpha
, casein kinase 1 alpha
, caesin kinase I alpha
, casein kinase 1
, casein kinase 1a
, casein kinase 1alpha
, casein kinase I
, casein kinase ialpha