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anti-Human CSNK1A1 Antikörper:
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Human Monoclonal CSNK1A1 Primary Antibody für ELISA, WB - ABIN536922
Knippschild, Wolff, Giamas, Brockschmidt, Wittau, Würl, Eismann, Stöter: The role of the casein kinase 1 (CK1) family in different signaling pathways linked to cancer development. in Onkologie 2005
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Human Polyclonal CSNK1A1 Primary Antibody für IP, PLA - ABIN438716
Hutchinson, Shanware, Chang, Tibbetts: Regulation of ribosomal protein S6 phosphorylation by casein kinase 1 and protein phosphatase 1. in The Journal of biological chemistry 2011
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Human Polyclonal CSNK1A1 Primary Antibody für IHC (p), ELISA - ABIN543836
Fish, Cegielska, Getman, Landes, Virshup: Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family. in The Journal of biological chemistry 1995
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Human Polyclonal CSNK1A1 Primary Antibody für IHC (p), WB - ABIN391597
Rodriguez, Yang, Hasselblatt, Liu, Zhou, Rauh-Hain, Ng, Choi, Fong, Agar, Welch, Berkowitz, Ng: Casein kinase I epsilon interacts with mitochondrial proteins for the growth and survival of human ovarian cancer cells. in EMBO molecular medicine 2012
CK1alpha bound the C-terminal tail of PTEN and enhanced both PTEN stability and activity by competitively antagonizing NEDD4-1-induced PTEN polyubiquitination and abrogating PTEN phosphorylation, thereby inhibiting AKT activity and activating FOXO3a-induced transcription of Atg7, to suppress lung tumor growth.
In summary, these results are indicative of a CKIalpha-mediated intramolecular, sequential phosphorylation cascade from S232 through S235 to S238 of the HCV NS5A protein. S225 and S229 also contribute substantially to the above sequential phosphorylation cascade of NS5A.
Study reports that CK1alpha similarly destabilizes FOXO4 in RAS-mutant cells by phosphorylation at serines 265/268.
Data indicate that casein kinase 1 alpha (CK1alpha) RNA levels might serve as prognostic marker for colorectal cancer (CRC).
cellular kinase, casein kinase 1alpha (CK1alpha), is crucial for IAV HA-induced degradation of both IFNGR1 and IFNAR1.
casein kinase 1 phosphorylates the SQSTM1 S349 residue when harmful proteins accumulate under HSF1 stress
Maintenance of the progenitors thus requires cooperation by PRMT1 and CSNK1a1 to sustain proliferation gene expression and suppress premature differentiation driven by GRHL3
These data indicate that CK1alpha has a dominant and non-redundant function in melanoma cells
Disruption of CK1alpha function in myeloma cells resulted in decreased Mdm2, increased p53 and p21 and reduced expression of beta-catenin and AKT.
CK1delta enhances EPO secretion from liver cancer cells under hypoxia by modifying HIF-2alpha and promoting its nuclear accumulation.
CKIalpha-mediated NS5A S235 phosphorylation is critical for HCV replication. CaMKII gamma and delta may have negative roles in the HCV life cycle.
Interactome analyses revealed that the Jade-1S mutant unable to be phosphorylated by CK1alpha has an increased binding affinity to proteins involved in chromatin remodelling, histone deacetylation, transcriptional repression, and ribosome biogenesis.
study focuses on, how the structural dynamics and conformational changes of two CK1 isoforms are synchronized in carcinogenic pathway
NIFK is required for lung cancer progression via the RUNX1-dependent CK1alpha repression, which activates TCF4/beta-catenin signaling in metastasis and the Ki-67-dependent regulation in cell proliferation.
The study describes the identification of a novel, tumor-specific missense mutation in the active site of casein kinase 1 alpha(CSNK1A1) using activity-based proteomics.
characterization of frequency and potential clinical impact of CSNK1A1 mutations in myelodysplastic syndrome(MDS) and acute myeloid leukemia following MDS in a large cohort of patients
The dynamical and conformational properties for each of three isoforms of CK1 are explored through molecular dynamics (MD) simulations.
Phosphorylation of LRRK2 by casein kinase 1alpha regulates trans-Golgi clustering via differential interaction with ARHGEF7.
Casein kinase 1alpha is a key negative regulator of oncogenic RAS-induced autophagy. Depletion or pharmacologic inhibition of CK1alpha enhanced autophagic flux in oncogenic RAS-driven human fibroblasts and multiple cancer cell lines.
CSNK1alpha1 has a role in mediating malignant plasma cell survival
Pro-opiomelanocortin (POMC), a precursor of alpha-melanocyte-stimulating hormone (alpha-MSH), was not activated in the CK1alpha ablation-induced hyperpigmentation, which is in contrast to the mechanism of p53-dependent UV tanning.
loss of one or two copies in the adipose lineage results in hyperglycaemia
Phosphorylation of FADD by the kinase CK1alpha promotes KRASG12D-induced lung cancer.
Csnk1a1 knockdown results in decreased Rps6 phosphorylation, increased p53 activity, and myeloid differentiation.
study for the first time demonstrates that CK1alpha is required for chromosome alignment and segregation during oocyte meiotic maturation and early embryo development
Silencing or deleting the p53 gene demonstrated that genotoxic stress elicited Wnt signaling in a p53-independent manner. Instead, this response occurred through reduced abundance of Csnk1a1 (CK1alpha), a kinase that inhibits beta-catenin.
maintenance of intestinal homeostasis in CKIalpha-deficient gut requires p53-mediated growth control, because the combined ablation of Csnk1a1 and either p53 or its target gene p21 triggered high-grade dysplasia with extensive proliferation
Casein kinase I and casein kinase II differentially regulate axin function
CK1alpha-mediated phosphorylation modulates the mRNA binding ability of hnRNP-C
CK1 regulates fast synaptic transmission by glutamate in brain. Activation of CK1 decreases NMDA receptor activity in the striatum via activation by this kinase of protein phosphatase 1 &/or 2A & increased dephosphorylation of NMDA receptors.
Casein kinase 1 alpha, a relevant double minute 2 (MDMX)-binding protein, plays an important role in regulating p53 activity in the absence or presence of stress.
Here, we report that in response to factors that promote cell motility, the Rap guanine exchange factor RAPGEF2 is rapidly phosphorylated by I-kappa-B-kinase-beta and casein kinase-1alpha and consequently degraded by the proteasome.
The phosphorylation of p53 by CK1 is an isoform-specific reaction to the K(221)RQK(224) loop.
data provide a molecular insight into the structural features that underlie the site specificity of CK1a
Sensitivy of a biosensor to detect alphas1-CN concentrations ranging from 8.8 to 12.06 mg/ml.
glucose regulatory role
we identify Casein Kinase I alpha (CK1alpha) as an additional negative-regulator of Cap-H2. CK1a-depletion stabilizes Cap-H2 protein and results in an accumulation of Cap-H2 on chromosomes.
Expected genes in the Scar-Arp2/3 actin nucleation pathway were identified as well as casein kinase I, which had a similar morphological RNAi signature.
CKI(Casein kinase I) functions as a negative regulator of Arm protein, by phosphorylating it on Ser and Thr residues in the N-terminus and targeting it for degradation.
2 proteins reported to function in Wingless(Wg) signaling identified as Hh pathway components: Dally-like protein required for Hh signal reception, and casein kinase 1alpha, a candidate tumor suppressor that regulates activities of both Hh and Wg pathways
expression of doubletime in Drosophila S2 cells produced a CKI-7-sensitive kinase activity which was reduced by both the dbt(S) and dbt(L) mutations of circadian rhythm
doubletime and CKII kinases collaborate to potentiate Drosophila PER transcriptional repressor activity
Several CKI isoforms including CKIalpha and Gish/CKIgamma can phosphorylate the Wg coreceptor Arrow (Arr), which may account, at least in part, for their positive roles in the Wg pathway.
Mutation of ck1alpha or -epsilon or sgg/gsk3beta in wing imaginal discs results in the accumulation of dMyc protein, suggesting a physiological role for these kinases in vivo.
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May play a role in segregating chromosomes during mitosis.
, casein kinase I isoform alpha
, clock regulator kinase
, down-regulated in lung cancer
, casein kinase I-alpha
, casein kinase I alpha LS
, epithelial keratin 1
, epithelial keratin-1
, keratin 1 (epidermolytic hyperkeratosis)
, keratin, type II cytoskeletal 1
, type-II keratin Kb1
, protein kinase CK1 (casein kinase 1) isoform alpha
, casein kinase 1 alpha
, CK II alpha
, casein kinase 2, alpha subunit
, casein kinase II subunit alpha
, caesin kinase I alpha
, casein kinase 1
, casein kinase 1a
, casein kinase 1alpha
, casein kinase I
, casein kinase ialpha