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Human AXIN1 Protein expressed in HEK-293 Cells - ABIN2715088
Cha, Cho, Lee, Lee, Jeong, Moon, Yun, Yang, Choi, Yoon, Kim, Kim, Kaduwal, Lee, Min, Kim, Han, Choi: Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation. in Nature chemical biology 2016
analysis of differential role of Axin RGS (zeige PITX2 Proteine) domain function in Wnt (zeige WNT2 Proteine) signaling during anteroposterior patterning and maternal axis formation
APC (zeige APC Proteine) and Axin are involved in the Wnt (zeige WNT2 Proteine) pathway
Axin binds directly to the export factor CRM1 (zeige XPO1 Proteine) in the presence of RanGTP
Genetic association of polymorphisms in AXIN1 gene with clear cell renal cell carcinoma (zeige MOK Proteine) in a Chinese population.
Colorectal cancer cell lines identified VACO6 cells as a carrier of a canonical PTPRK (zeige PTPRK Proteine)(e1)-RSPO3 (zeige RSPO3 Proteine)(e2) fusion; cell line displayed marked in vitro and in vivo sensitivity to WNT (zeige WNT2 Proteine) blockade by the porcupine (zeige PORCN Proteine) inhibitor LGK974. Long-term treatment of VACO6 cells with LGK974 led to the emergence of a resistant population carrying two frameshift deletions of the WNT (zeige WNT2 Proteine) pathway inhibitor AXIN1, with consequent protein loss.
role in the formation of degradasomes and degradation of beta-catenin (zeige CTNNB1 Proteine) induced by the TNKSi G007-LK in colorectal cancer cells
VDR (zeige CYP27B1 Proteine) is important for the maintenance of physiological level of Axin1
RUNX1 (zeige RUNX1 Proteine) and AXIN1 proteins are strongly correlated in ER(-) tumors as well.
Mutagenesis and binding studies using the bivalent TNKS (zeige TNKS Proteine) binding domain of Axin1 demonstrate that only certain ankyrin repeat clusters combinations function together. SAXS analysis is consistent with a dynamic ensemble of TNKS (zeige TNKS Proteine) ankyrin repeat conformations modulated by Axin1 interaction.
LGALS3 (zeige LGALS3 Proteine) and AXIN1 genes affect tumor sizes and the mucinous component via Wnt (zeige WNT2 Proteine)/ beta-catenin (zeige CTNNB1 Proteine) pathway in the pathogenesis of colorectal cancer
The AXIN1 rs1805105 SNP was associated with small tumor size and early tumor stage in hepatocellular carcinoma.
AXIN1 is expressed in meningioma along with APC (zeige APC Proteine) and E-cadherin (zeige CDH1 Proteine)
Data show that poly(ADP-ribose) polymerase (PARP (zeige PARP1 Proteine)) enzyme Tankyrase (TNKS (zeige TNKS Proteine)) inhibition in colon cancer cells decreases beta-catenin (zeige CTNNB1 Proteine) signaling at the level of both Axin and APC2.
Axin-1 is critical for spindle organization and cell cycle progression during meiotic maturation in mouse oocytes.
Axin1 promotes dendritic spine stabilization through Cdc42 (zeige CDC42 Proteine)-dependent cytoskeletal reorganization.
Axin1 and Axin2 (zeige AXIN2 Proteine) do not have equivalent functions in satellite cells, but are both involved in repression of Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signalling to maintain proliferation and contribute to controlling timely myogenic differentiation.
Study reports that NRF2 (zeige NFE2L2 Proteine) participates in the formation of a protein complex with Axin1/GSK-3/beta-TrCP (zeige BTRC Proteine) that is disrupted by WNT-3A (zeige WNT3A Proteine), a prototypic canonical WNT (zeige WNT2 Proteine) ligand, and leads to upregulation of the NRF2 (zeige NFE2L2 Proteine) transcriptional signature.
Smurf1 (zeige SMURF1 Proteine)-mediated Lys29-linked nonproteolytic polyubiquitination of axin1 negatively regulates Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling.
This study demonistrated that Axin directs the amplification and differentiation of intermediate progenitors in the developing cerebral cortex in mice.
results suggestg HSV-1 replication enhancement might be mediated by the axin RGS (zeige PITX2 Proteine) domain.
an asymmetrical distribution pattern for Axin1 transcripts in 2-cell embryos.
Conditional disruption of Axin1 leads to development of liver tumors in mice.
beta-catenin1 cannot revert the ich (zeige ACE Proteine) phenotype because it may be under the control of a GSK3beta-independent mechanism that required Axin's RGS (zeige PITX2 Proteine) domain function.
Wnt (zeige WNT2 Proteine)/Axin/beta-catenin (zeige CTNNB1 Proteine) pathway has a role in ventral CNS development
Overactivation of Wnt (zeige WNT2 Proteine)/Axin1/beta-catenin (zeige CTNNB1 Proteine) signaling during late gastrulation leads to bilateral epithalamic expression of Nodal pathway genes independently of lateral plate mesoderm Nodal signaling.
A dorsalization pathway that is exerted by Axin/JNK (zeige MAPK8 Proteine) signaling and its inhibitor Aida (zeige AIDA Proteine) during vertebrate embryogenesis, is defined.
Dab2 (zeige DAB2 Proteine) stabilizes Axin and attenuates Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling by preventing PP1 from binding Axin
This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene.
, axin 1, isoform 1
, axis inhibition protein 1
, axis inhibitor 1
, fused, mouse, homolog of
, protein phosphatase 1, regulatory subunit 49
, protein Fused
, GSK-3beta interacting protein rAxin