UGT1A8 Proteine
(UDP Glucuronosyltransferase 1 Family, Polypeptide A8 (UGT1A8))
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity with many substrates including coumarins, phenols, anthraquinones, flavones, and some opioids.
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Empfohlene UGT1A8 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Insect Cells
Validierungen
- (1)
Kat. Nr.
ABIN3118233
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (1)
Kat. Nr.
ABIN2734969
Menge
20 μg
Datenblatt
Datenblatt
Synonyme und alternative Namen zu UGT1A8
UDP glucuronosyltransferase 1 family, polypeptide A8 (UGT1A8), UDP glucuronosyltransferase family 1 member A8 (UGT1A8), UDP glucuronosyltransferase 1 family, polypeptide A8 (Ugt1a8), UDP glycosyltransferase 1 family, polypeptide A8 (Ugt1a8), A116, OTTMUSG00000020811, UDPGT, UDPGT 1-8, UGT-1H, Ugt1, UGT1-08, UGT1.8, UGT1A8S, Ugt1a9, UGT1HBezeichner auf Proteinebene für UGT1A8
- UDP-glucuronosyltransferase 1-8
- UDP glycosyl transferase 1A8
- UDP glycosyltransferase 1 family, polypeptide A8
- UDP-glucuronosyltransferase 1 family polypeptide A8s
- UDP-glucuronosyltransferase 1-H
- UDP-glucuronosyltransferase 1A8
- A3
- UDPGT
- UGT1*8
- UGT1-08
- UGT1.8
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