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Human Polyclonal TRIM71 Primary Antibody für ELISA, WB - ABIN4331053
Lin, Hsieh, Kuo, Yu, Kuo, Lo, Lin, Yu, Li: Human TRIM71 and its nematode homologue are targets of let-7 microRNA and its zebrafish orthologue is essential for development. in Molecular biology and evolution 2007
TRIM71 acts through post-transcriptional repression of Lin28B and subsequent modulation of let-7-HMGA2 signaling during tumorigenesis to potentially function as a tumor suppressor.
Studies indicate most-studied TRIpartite Motif (TRIM (zeige TRAT1 Antikörper))-NHL (zeige RTEL1 Antikörper) proteins TRIM2 (zeige TRIM2 Antikörper), TRIM3 (zeige TRIM3 Antikörper), TRIM32 (zeige TRIM32 Antikörper) and TRIM71, and their mutations have been linked to diseases.
Consistent with the let-7 microRNA stimulatory role of TRIM71 via Lin28B (zeige LIN28B Antikörper) polyubiquitination.
The stem cell E3-ligase Lin-41 promotes liver cancer progression through inhibition of microRNA-mediated gene silencing.
Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation
Repression of human TRIM71 and the zebrafish lin-41 ortholog was abolished when predicted let-7 target sites were mutated. Regulation of TRIM71 expression by let-7 seems to have been evolutionarily conserved.
LIN41 interacts with p53 (zeige TP53 Antikörper), controls its abundance by ubiquitination and antagonizes p53 (zeige TP53 Antikörper)-dependent pro-apoptotic and pro-differentiation responses. In vivo, lack of LIN41 is associated with upregulation of Grhl3 (zeige GRHL3 Antikörper) and widespread caspase-3 (zeige CASP3 Antikörper) activation, 2 downstream effectors of p53 (zeige TP53 Antikörper) with essential roles in neural tube closure.
suggest that Trim71 keeps priming steps of differentiation in check, which do not pre-require a loss of the pluripotency network in ES cells
Two well-known E3 ubiquitin ligases, Trim25 (zeige TRIM25 Antikörper) (also called Efp (zeige TRIM25 Antikörper)) and Trim71 (also called Lin41), are validated as RNA-binding proteins, revealing a potential link between RNA biology and protein-modification pathways.
mLin41 acts as a temporal regulator to promote neural progenitor cell maintenance, not via the regulation of AGO2 (zeige EIF2C2 Antikörper) stability, but through FGF signaling.
Lin-41 is genetically and biochemically downstream of both the Shh (zeige SHH Antikörper) and Fgf signaling pathways and is expressed in three phases over developmental time and most notably is associated with the developing autopod.
lin-41 is temporally regulated by miRNAs in order to direct key developmental events such as limb formation.
May be involved in controlling the timing of organ formation during development (By similarity).
E3 ubiquitin-protein ligase TRIM71
, abnormal cell LINeage LIN-41
, homolog of C. elegans Lin-41
, protein lin-41 homolog
, tripartite motif-containing 71
, tripartite motif-containing protein 71
, B-box zinc finger, Filamin and NHL repeat containing protein (123.8 kD) (lin-41)
, Drosophila dappled/ vertebrate TRipartite Motif protein related
, lin-41 homolog