anti-STK3 (STK3) Antikörper

Human serine/threonine Kinase 3 (STK3) Interaktionspartner

1. Through a comprehensive set of biochemical, biophysical, mutational and structural studies, we quantitatively assess how phosphorylation of MOB1A (zeige MOBKL1B Antikörper) regulates its interaction with both MST (zeige MAP3K10 Antikörper) kinases and LATS (zeige LATS1 Antikörper)/NDR (zeige STK38 Antikörper) family kinases in vitro.

2. In this study, we investigated the mechanisms behind the recruitment of MST1 (zeige MST1 Antikörper) and MST2 kinases to MOB1 (zeige MOBKL3 Antikörper), which facilitate signal transmission in the Hippo pathway by bringing the MST1 (zeige MST1 Antikörper) and MST2 kinases in close vicinity to their substrates, the LATS (zeige LATS1 Antikörper) family kinases.

3. Findings indicate that long-term exposure to IM results in dysregulation of stem cell renewal-regulatory Hippo (MST1 (zeige MST1 Antikörper)/2)/YAP (zeige YAP1 Antikörper) signaling, and that inhibition of miR (zeige MLXIP Antikörper)-181a using a microRNA sponge inhibitor resulted in decreased transcription of SOX2 (zeige SOX2 Antikörper) and SALL4 (zeige SALL4 Antikörper).

4. These findings reveal a novel layer of regulation for MST2 in mitosis and its role in tumorigenesis.

5. TNFAIP8 (zeige TNFAIP8 Antikörper) regulates Hippo (MST1 (zeige MST1 Antikörper)/2) signaling through its interaction with LATS1 (zeige LATS1 Antikörper).

6. Data suggest that Hippo (MST1 (zeige MST1 Antikörper)/2 protein kinases) - Yes associated protein 1 (YAP (zeige YAP1 Antikörper)) pathway involved in carcinogenesis of pancreatic cancer and in the inhibition effect of stiehopus japonieus acidic mucopolysaccharide (SJAMP) to the proliferation of pancreatic cancer cell.

7. H-ras (zeige HRAS Antikörper), via an Erk (zeige EPHB2 Antikörper)-dependent mechanism, downregulates Mst1 (zeige MST1 Antikörper)/Mst2 activity by inducing the formation of inactive Mst1 (zeige MST1 Antikörper)/Mst2 heterodimers.

8. Results show that STK3 is targeted by Casp6 (zeige CASP6 Antikörper) and demonstrate that alterations in STK3 protein expression levels and post-translational modifications are detected in a cellular model of HD and caspase (zeige CASP3 Antikörper)-mediated generation of STK3 fragments observed under conditions of stress in cells expressing mhtt.

9. using an Mst2 mutation that disrupts homotypic dimerization, we showed that the monomeric Mst2-SARAH domain could form a stable complex of 1:1 stoichiometric ratio with WW45 (zeige SAV1 Antikörper) refolded under acidic pH.

10. The MST1/2-SAV1 complex, a core component of the Hippo pathway, promotes ciliogenesis.

Mouse (Murine) serine/threonine Kinase 3 (STK3) Interaktionspartner

1. It is involved in apoptosis and serine/threonine kinase 3 (STK3 (zeige PKN1 Antikörper)) is a recently identified caspase-6 (zeige CASP6 Antikörper) substrate.

2. Using a standard two-thirds partial hepatectomy (PH) model in young and aged mice, the activity of the core kinases MST1 (zeige MST1 Antikörper) and LATS1 (zeige LATS1 Antikörper) increased during the early hypertrophic phase and returned to steady state levels in the proliferative phase, coinciding with activation of YAP1 (zeige YAP1 Antikörper) target genes and hepatocyte proliferation.

3. Studies indicate that Hippo (Hpo (zeige GFER Antikörper); MST1 (zeige MST1 Antikörper)/2 in mammals) signaling pathway plays a central role in the cell fate-specification process.

4. Mst2 is involved in bone homeostasis, functioning as a reciprocal regulator of osteoclast and osteoblast differentiation through the NF-kappaB (zeige NFKB1 Antikörper) pathway

5. the TLR-Mst1 (zeige MST1 Antikörper)-Mst2-Rac (zeige AKT1 Antikörper) signaling axis is critical for effective phagosome-mitochondrion function and bactericidal activity

6. These data indicate that that inhibition of mammalian sterile 20-like kinase 1 (zeige STK4 Antikörper) rescued cardiac fibrosis and myocardial dysfunction in chronic beta1-adrenergic receptor stimulation-induced cardiomyopathy

7. Phosphorylation of LC3 (zeige MAP1LC3A Antikörper) by the STK3 (zeige PKN1 Antikörper) and STK4 is essential for autophagy.

8. These results identify MST2, not MST1 (zeige MST1 Antikörper), as a critical regulator of caspase (zeige CASP3 Antikörper)-mediated photoreceptor cell death in the detached retina and indicate its potential as a future neuroprotection target.

9. results reveal a novel role of Mst2 in stress-dependent cardiac hypertrophy and remodeling in the adult mouse and likely human heart

10. Mst1 (zeige MST1 Antikörper)/2 regulate placental development by control of trophoblast cell differentiation and labyrinthine vasculature at midgestation and Mst1 (zeige MST1 Antikörper)/2 control labyrinth morphogenesis in trophoblast- and fetal endothelial-dependent manners.