STK3 Antikörper (AA 228-252)

Produktnummer ABIN1882187

Produktdetails anti-STK3 Antikörper

Target: STK3 (serine/threonine Kinase 3 (STK3))

Bindungsspezifität: AA 228-252

Reaktivität: Human, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STK3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This DANRE stk3(36kDa subunit) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 228-252 amino acids from the Central region of DANRE stk3(36kDa subunit).

Klon: RB47395

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu STK3

Target: STK3 (serine/threonine Kinase 3 (STK3))

Andere Bezeichnung: stk3 (STK3 Produkte)

Synonyme: KRS1 antikoerper, MST2 antikoerper, 0610042I06Rik antikoerper, MST antikoerper, Mst2 antikoerper, Mst3 antikoerper, Ste20 antikoerper, mess1 antikoerper, mst2 antikoerper, xstk3 antikoerper, wu:fc19e11 antikoerper, zgc:55383 antikoerper, serine/threonine kinase 3 antikoerper, serine/threonine kinase 3 S homeolog antikoerper, serine/threonine kinase 3 (STE20 homolog, yeast) antikoerper, STK3 antikoerper, Stk3 antikoerper, stk3.S antikoerper, stk3 antikoerper

Hintergrund: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein stk3/mst2 and stk4/mst1, in complex with its regulatory protein sav1, phosphorylates and activates lats1/2 in complex with its regulatory protein mob1, which in turn phosphorylates and inactivates yap1 oncoprotein and wwtr1/taz. Phosphorylation of yap1 by lats2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (By similarity).

Molekulargewicht: 56081

UniProt: Q7ZUQ3

Pathways: Tube Formation