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Study shows that plexin-B2 (PLXNB2) is the functional receptor for ANG (zeige ANG ELISA Kits) in endothelial, cancer, neuronal, and normal hematopoietic and leukemic stem and progenitor cells.
Analysis of the interaction of Plexin-B1 (zeige PLXNB1 ELISA Kits) and Plexin-B2 with Rnd family proteins shows lack of binding specificity.
plexin-B2 is a downstream target for Rnd3 (zeige RND3 ELISA Kits), which contributes to its cellular function.
Results show that decreased expression of Sema4D (zeige SEMA4D ELISA Kits), plexin-B1 (zeige PLXNB1 ELISA Kits) and -B2 was associated with local recurrence and poor prognosis of breast neoplasm.
Two related guanine nucleotide exchange factors (GEFs), PDZ-RhoGEF (zeige ARHGEF11 ELISA Kits) and leukemia-associated RhoGEF (LARG (zeige ARHGEF12 ELISA Kits)), use their PDZ (zeige INADL ELISA Kits) domains to bind class B plexins and play critical roles in signaling.
Plexin-B2 promotes glioma invasion and vascularization
Blocking of CD100 (zeige SEMA4D ELISA Kits), plexin B1 (zeige PLXNB1 ELISA Kits) and/or B2 in adhesion experiments have shown that both CD100 (zeige SEMA4D ELISA Kits) and plexins act as adhesion molecules involved in monocyte-endothelial cell binding.
In endometrial luminal epithelium, cadherin 6 (zeige CDH6 ELISA Kits), desmoglein 2 (zeige DSG2 ELISA Kits) and plexin b2 were surprisingly found in the apical as well as the lateral membrane domain; their knock-down compromised epithelial integrity.
High PLEXIN B2 expression is associated with high-grade gliomas.
Plexin B2 associates directly with two members of a recently identified family of Dbl homology/pleckstrin (zeige PLEK ELISA Kits) homology containing guanine nucleotide exchange factors for Rho, PDZ-RhoGEF (zeige ARHGEF11 ELISA Kits), and Leukemia-associated Rho GEF (LARG (zeige ARHGEF12 ELISA Kits)).
Plexin-B1 (zeige PLXNB1 ELISA Kits) and -B2 play redundant or compensatory roles during forebrain development to ensure proper neuronal production and neocortical expansion.
During kidney morphogenesis and repair, renal tubular epithelial cells lacking the transmembrane receptor Plexin-B2 or its semaphorin ligands fail to correctly orient the mitotic spindle
Data show that the Plexin B2 receptor interacts physically and functionally with Rnd3 (zeige RND3 ELISA Kits) and stimulates RhoA (zeige RHOA ELISA Kits) activity in migrating cortical neurons.
In contrast to the GAP domain mutants, Plexin-B2 transgenic mice defective in Rho guanine nucleotide exchange factor (zeige ARHGEF28 ELISA Kits) binding are viable and fertile but exhibit abnormal development of the liver vasculature
these results show that Plexin-B2 plays a role in postnatal neurogenesis and in the migration of subventricular zone-derived neuroblasts
Data an association between Plexin-B2 and Plexin-D1 (zeige PLXND1 ELISA Kits) with the negative regulation of IL-12 (zeige IL12A ELISA Kits)/IL-23p40 in DCs.
In vitro blocking of plexin B2 or CD100 (zeige SEMA4D ELISA Kits) inhibited gamma-delta T cell activation.
Data show that Plexin-B2 functions in macrophages as a negative regulator of the GTPases Rac (zeige AKT1 ELISA Kits) and Cdc42 (zeige CDC42 ELISA Kits) and as a negative regulator of basal cell motility and wound healing.
deletion of Plexin B2 (Plxnb2), a semaphorin receptor that is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney, results in renal hypoplasia and occasional double ureters
We have identified here Sema4C (zeige SEMA4C ELISA Kits) and Sema4G (zeige SEMA4G ELISA Kits) as candidate ligands for Plexin-B2
Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002)
, differentially expressed in brain tumors