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Osr1/Osr2 normally repress bmp4 expression in the lateral plate mesoderm prior to respiratory specification.
Odd genes may also be required for proper development of the Malpighian tubules, the Drosophila renal organs
nephrogenic transcription factors (osr1, osr2, hnf1b, lhx1, pax8)play important role in nephrogenesis but have no pronephros induction potential upon overexpression; they activate transcription cascades reflecting activation by activin A, retinoic acid
Kir2.1 and Kir2.3, are activated by OSR1 through a motif variant, R-x-F-x-V/I.
Odd-skipped related 1 (OSR1) downregulated the activity of the Wnt signaling pathway by suppressing the expression of sex-determining region Y-box 9 (SOX9) and beta-catenin.
OSR1 was downregulated in RCC cells by promoter methylation. OSR1 can function as a tumor suppressor via inhibition of invasion and proliferation in RCC cells, possibly via upregulating tumor suppressor genes and downregulating oncogenes.
OSR1 was sequenced in 186 children with primary vesicoureteric reflux, and 17 have single nucleotide polymorphisms
In summary, our study implicated a gene network involving Tbx5, Osr1 and Pcsk6 interaction in second heart field for atrial septation, providing a molecular framework for understanding the role of Tbx5 in congenital heart disease ontogeny.
The findings of the present study showed, for the first time, the role of the OSR1 rs12329305 polymorphism in the development of congenital malformations in cases of stillborn/neonatal death.
OSR1 acts as a functional tumour suppressor in gastric cancer
OSR1 is expressed in human mesenchymal stem cells, the blastemal component of Wilms tumors and CD24+/CD133+ progenitor cells isolated from the mature kidney.
first report on molecular cloning and characterization of human OSR1
Transcriptome and functional analyses reveal that Osr1(+) cells provide a critical pro-myogenic niche via the production of muscle connective tissue specific extracellular matrix components and secreted signaling factors.
Hypothalamic OSR1 expression is suppressed by enhanced postnatal (maternal) care, but elevated by inflammatory microglia.
In contrast to H2A-interacting proteins, the H2A.Z-interacting proteins are involved in transcriptional regulation. We found that the transcription factor Osr1 interacts with H2A.Z both in vitro and in vivo. It also mediates H2A.Z incorporation to a large number of target sites and regulates gene expression
These results indicate that OSR1 and SPAK cooperatively regulate NKCC1-dependent spermatogenesis in a SC-restricted manner.
Osr1 is a candidate gene implicated in the pathogenesis of vesicoureteric reflux and congenital abnormalities of the kidney and urinary tract in mice
Our data reveal that together SPAK and OSR1 play essential roles in the pathway along the distal convoluted tubules that responds to fluctuations in plasma potassium
These results indicate that Osr1 and Wt1 act synergistically to regulate nephron endowment by controlling metanephric mesenchyme specification during early nephrogenesis.
Tbx5 and Osr1 interact to regulate posterior second heart field cell cycle progression for cardiac septation.
odd-skipped related 1 is involved in regulation of mammalian kidney development
ROMK1 protein abundance and activity are down-regulated by SPAK and OSR1
study identifies a separation of functions for the WNK1-activated protein kinases OSR1 and SPAK in mediating proliferation, invasion, and gene expression in endothelial cells
WNK 1, 3, 4, OSR1, and SPAK signaling system known to play a role in regulating the phosphorylation status, and hence activity of the CCCs in other tissues, is also present in the rat and human lenses.
Osr1 plays crucial roles in Six2-dependent maintenance of nephron progenitors during mammalian nephrogenesis.
Data indicate that Activin A and retinoic acid (RA) induced theto embryonic stem cells (mESCs) expression of marker genes and proteins for intermediate mesoderm, odd-skipped related 1 (Osr1) and Wilms Tumor 1 (Wt1).
Odd-skipped related-1 controls neural crest chondrogenesis during tongue development.
OSR1 is expressed in proximal renal tubules and participates in the regulation of FGF23 release and renal tubular phosphate transport.
WNK1 activation of the OSR1 signaling cascade is an essential pathway that regulates angiogenesis and cardiac formation during mouse embryo development.
Studies indicate that the Osr1 conditional mice will be valuable for tissue-specific analysis of the roles of Osr1 in embryonic and postnatal developmental processes.
These data indicate that Osr1 and Osr2 function redundantly to control synovial joint formation.
hand2 and the co-expressed zinc-finger transcription factor osr1 have functionally antagonistic influences on kidney development. Together, our data suggest that hand2 functions in opposition to osr1 to balance the formation of kidney and vein progenitors by regulating cell fate decisions at the lateral boundary of the Iintermediate mesoderm
findings identify osr1 as a Nodal-induced, negative feedback regulator of Nodal signaling that acts at the earliest stages of endoderm differentiation to limit the number of endoderm progenitors.
Our results place osr1 in a framework of transcriptional regulators that control the expression of podocin and nephrin and thereby mediate podocyte differentiation.
The Osr1 and Osr2 genes act in the pronephric anlage downstream of retinoic acid signaling and upstream of Wnt2b to maintain pectoral fin development.
osr1 reveals a novel role for endoderm in regulating kidney versus vascular cell fate.
Transcription factor that plays a role in the regulation of embryonic heart and urogenital development (By similarity).
odd-skipped related 1 (Drosophila)
, protein odd-skipped-related 1
, zinc finger transcription factor
, odd-skipped homolog
, oxidative-stress responsive 1