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Osr1/Osr2 normally repress bmp4 (zeige BMP4 Proteine) expression in the lateral plate mesoderm prior to respiratory specification.
nephrogenic transcription factors (osr1, osr2, hnf1b (zeige HNF1B Proteine), lhx1 (zeige LHX1 Proteine), pax8 (zeige PAX8 Proteine))play important role in nephrogenesis but have no pronephros induction potential upon overexpression; they activate transcription cascades reflecting activation by activin A (zeige INHBA Proteine), retinoic acid
OSR1 (zeige OXSR1 Proteine) was downregulated in RCC (zeige XRCC1 Proteine) cells by promoter methylation. OSR1 (zeige OXSR1 Proteine) can function as a tumor suppressor via inhibition of invasion and proliferation in RCC (zeige XRCC1 Proteine) cells, possibly via upregulating tumor suppressor genes and downregulating oncogenes.
OSR1 (zeige OXSR1 Proteine) was sequenced in 186 children with primary vesicoureteric reflux, and 17 have single nucleotide polymorphisms
Both SPAK (zeige STK39 Proteine) and OSR1 (zeige OXSR1 Proteine) kinases entering cells through exosomes are preferentially expressed at the plasma membrane and that the kinases in exosomes are functional and maintain NKCC1 (zeige SLC12A2 Proteine) in a phosphorylated state.
In summary, our study implicated a gene network involving Tbx5 (zeige TBX5 Proteine), Osr1 (zeige OXSR1 Proteine) and Pcsk6 interaction in second heart field for atrial septation, providing a molecular framework for understanding the role of Tbx5 (zeige TBX5 Proteine) in congenital heart disease ontogeny.
SPAK (zeige STK39 Proteine) and OSR1 (zeige OXSR1 Proteine) are both stimulators of Kir2.1 (zeige KCNJ2 Proteine) activity.
SPAK (zeige STK39 Proteine) and OSR1 (zeige OXSR1 Proteine) are powerful stimulators of the intestinal Na+-coupled phosphate co-transporter NaPi-IIb (zeige SLC34A2 Proteine)
OSR1 (zeige OXSR1 Proteine) protein has both the potential to up-regulate KCNQ1 (zeige KCNQ1 Proteine)/E1 protein abundance in the cell membrane, an effect possibly participating in the regulation of cell volume, excitability, epithelial transport and metabolism.
SPAK (zeige STK39 Proteine) and OSR1 (zeige OXSR1 Proteine) are powerful negative regulators of the excitatory glutamate (zeige GRIN1 Proteine) transporters EAAT1 (zeige SLC1A3 Proteine) and EAAT2 (zeige SLC1A2 Proteine).
SPAK (zeige STK39 Proteine) and OSR1 (zeige OXSR1 Proteine) are negative regulators of EAAT3 (zeige SLC1A1 Proteine) activity
OSR1 has the capacity to downregulate the peptide transporters PEPT1 and PEPT2 by decreasing the carrier protein abundance in the cell membrane
Osr1 is a candidate gene implicated in the pathogenesis of vesicoureteric reflux and congenital abnormalities of the kidney and urinary tract in mice
Our data reveal that together SPAK (zeige STK39 Proteine) and OSR1 play essential roles in the pathway along the distal convoluted tubules that responds to fluctuations in plasma potassium
These results indicate that Osr1 and Wt1 (zeige WT1 Proteine) act synergistically to regulate nephron endowment by controlling metanephric mesenchyme specification during early nephrogenesis.
Tbx5 (zeige TBX5 Proteine) and Osr1 interact to regulate posterior second heart field cell cycle progression for cardiac septation.
odd-skipped related 1 is involved in regulation of mammalian kidney development
ROMK1 (zeige KCNJ1 Proteine) protein abundance and activity are down-regulated by SPAK (zeige STK39 Proteine) and OSR1
study identifies a separation of functions for the WNK1 (zeige WNK1 Proteine)-activated protein kinases OSR1 and SPAK (zeige STK39 Proteine) in mediating proliferation, invasion, and gene expression in endothelial cells
WNK 1 (zeige WNK1 Proteine), 3, 4, OSR1, and SPAK (zeige STK39 Proteine) signaling system known to play a role in regulating the phosphorylation status, and hence activity of the CCCs in other tissues, is also present in the rat and human lenses.
Osr1 plays crucial roles in Six2 (zeige SIX2 Proteine)-dependent maintenance of nephron progenitors during mammalian nephrogenesis.
Data indicate that Activin A (zeige INHBA Proteine) and retinoic acid (RA) induced theto embryonic stem cells (mESCs) expression of marker genes and proteins for intermediate mesoderm, odd-skipped related 1 (Osr1) and Wilms Tumor 1 (Wt1 (zeige WT1 Proteine)).
hand2 (zeige HAND2 Proteine) and the co-expressed zinc-finger transcription factor osr1 have functionally antagonistic influences on kidney development. Together, our data suggest that hand2 (zeige HAND2 Proteine) functions in opposition to osr1 to balance the formation of kidney and vein progenitors by regulating cell fate decisions at the lateral boundary of the Iintermediate mesoderm
findings identify osr1 as a Nodal-induced, negative feedback regulator of Nodal signaling that acts at the earliest stages of endoderm differentiation to limit the number of endoderm progenitors.
Our results place osr1 in a framework of transcriptional regulators that control the expression of podocin and nephrin (zeige NPHS1 Proteine) and thereby mediate podocyte differentiation.
The Osr1 and Osr2 genes act in the pronephric anlage downstream of retinoic acid signaling and upstream of Wnt2b (zeige WNT2B Proteine) to maintain pectoral fin development.
osr1 reveals a novel role for endoderm in regulating kidney versus vascular cell fate.
Transcription factor that plays a role in the regulation of embryonic heart and urogenital development (By similarity).
odd-skipped related 1 (Drosophila)
, protein odd-skipped-related 1
, zinc finger transcription factor
, odd-skipped homolog
, oxidative-stress responsive 1