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Data suggest a solid basis for further research into understanding how six-transmembrane epithelial antigen of prostate member 1 (STEAP1) activities may affect cancer progression.
These findings highlight the ability of immuno-PET with (89)Zr-2109A to detect acute changes in STEAP1 expression
Data indicate that six transmembrane epithelial antigen of the prostate 1 (STEAP1) is consistently overexpressed in malignant prostate tissue, namely adenocarcinoma and prostatic intraepithelial neoplasia (PIN (zeige DYNLL1 Proteine)) lesions.
The findings provide evidence that STEAP1 is a biomarker of worse prognosis in prostate carcinomas patients.
STEAP1 is down-regulated by dihydrotestosterone and estradiols in LNCaP cells and in rat prostate.
STEAP1 overexpression predicts improved outcome of Ewing's sarcoma patients, possibly due to enhanced sensitivity towards ROS (zeige ROS1 Proteine)-generating chemotherapeutics.
EWS (zeige EWSR1 Proteine)-FLI1 (zeige FLI1 Proteine) mediated overexpression of STEAP1 increases the invasiveness and oxidative stress levels of Ewing tumor cells.
Studies suggest that activated human gammadelta T cells can efficiently present PRAME (zeige PRAME Proteine) and STEAP1-derived epitopes and allow breaking tolerance against these tumor-associated self-antigens.
Data suggest that zoledronic acid may affect cancer cells also by targeting the gene expression of STEAP.
Peptide STEAP-292.2L (MLAVFLPIV) may have potential as an antitumor peptide vaccine.
Data show that six-transmembrane epithelial antigen of prostate member 1 (STEAP1) is capable of reducing transition metal ion complexes of Fe(3+) and Cu(2+).
This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions.
, six-transmembrane epithelial antigen of prostate 1
, six transmembrane epithelial antigen of the prostate 1
, metalloreductase STEAP1-like
, six transmembrane endothelial antigen of PAEC