Solute Carrier Family 39 (Metal Ion Transporter), Member 5 Proteine (SLC39A5)

Mouse (Murine) Solute Carrier Family 39 (Metal Ion Transporter), Member 5 (SLC39A5) Interaktionspartner

1. The zinc transporter Zip5 (Slc39a5) regulates intestinal zinc excretion and protects the pancreas against zinc toxicity.

2. ZIP5 is directed to the same subcellular locations as PrP(C) and both proteins are seen to be endocytosed through vesicles decorated with the Rab5 marker protein.

3. miR-328 and miR-193a are expressed in tissues known to regulate Zip5 mRNA translation in response to zinc availability and both are polysome-associated consistent with Zip5 mRNA localization

4. Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells

5. ZIP4 and ZIP5 have roles in the adaptive response to dietary zinc in mice [ZIP5]

6. temporal and spatial patterns of expression of the mouse ZIP1, 3, 4, and 5 genes in the developing intestine and the effects of maternal dietary zinc deficiency on these patterns of expression were examined

7. Zip5 mRNA abundance does not change in response to zinc, but the translation of this mRNA was found to be zinc-responsive

Human Solute Carrier Family 39 (Metal Ion Transporter), Member 5 (SLC39A5) Interaktionspartner

1. we found that downregulation of ZIP5 by RNA interference inhibited esophageal cancer growth in vivo, reduced the expression of COX2, and promoted the expression of E-cadherin.

2. ZIP5 knockdown inhibited the proliferation, migration and invasion of ESCC and suppressed COX2, cyclin D1 and E-cadherin expression, which led to the inhibition of cell progression in esophageal squamous cell carcinoma .

3. mutation in LRPAP1 is associated with high myopia. Further studies are expected to evaluate the pathogenicity of the variants in CTSH, LEPREL1, ZNF644, SLC39A5, and SCO2.

4. Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells