NDFIP1 Proteine (NDFIP1)

Bezeichnung:
Nedd4 Family Interacting Protein 1 Proteine (NDFIP1)
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Synonyme:
0610010M22Rik, MGC108163, N4wbp5, NDFIP1, wu:fc17e11, zgc:55546
alle Proteine anzeigen Gen GeneID UniProt
NDFIP1 80762 Q9BT67
NDFIP1 65113 Q8R0W6
Ratte NDFIP1 NDFIP1 291609 Q5U2S1

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Weitere Proteine zu NDFIP1 Interaktionspartnern

Human Nedd4 Family Interacting Protein 1 (NDFIP1) Interaktionspartner

  1. Silencing of Ndfip1 inhibited cytokine-induced apoptosis of pancreatic islets and promoted glucose-stimulated insulin (zeige INS Proteine) secretion. These effects were associated with an increase in the cellular content of JunB (zeige JUNB Proteine), a potent inhibitor of ER stress and apoptosis.

  2. Data show that membrane protein Ndfip1 recruits E3 ubiquitin (Ub) ligase Nedd4-2 to the Golgi to target ether-a-go-go-related gene (hERG) channel for degradation while membrane protein Ndfip2 also mediates Nedd4-2 interaction with hERG in the Golgi.

  3. Ndfip1 is required during stress for ubiquitinating and trafficking BRAT1 (zeige C7orf27 Proteine) into the nucleus.

  4. In Parkinson's disease, increased iron levels are associated with increased Ndfip1 expression for the regulation of DMT1 (zeige DMRT1 Proteine), including abnormal Ndfip1 activation in non-neuronal cell types such as astrocytes.

  5. Ndfip1 negatively regulates RIG-I (zeige DDX58 Proteine)-dependent immune signaling by enhancing E3 ligase Smurf1 (zeige SMURF1 Proteine)-mediated MAVS (zeige MAVS Proteine) degradation.

  6. Cellular up-regulation of Nedd4 family interacting protein 1 (Ndfip1) using low levels of bioactive cobalt complexes.

  7. PTEN/Akt (zeige AKT1 Proteine) and MAP kinase (zeige MAPK1 Proteine) signaling pathways are regulated by the ubiquitin ligase activators Ndfip1 and Ndfip2 (zeige NDFIP2 Proteine)

  8. Ndfip1 is required for the exosomal secretion of Nedd4 family proteins

  9. Data show that the small PY-containing membrane proteins, NDFIP1 and NDFIP2 (NEDD4 family-interacting proteins), activate the catalytic activity of ITCH and of several other HECT ligases by binding to them.

  10. Ndfip1 plays a critical role in regulating metal transport in human neurons through its regulation of DMT1 (zeige DMRT1 Proteine).

Mouse (Murine) Nedd4 Family Interacting Protein 1 (NDFIP1) Interaktionspartner

  1. Data indicate thar Janus kinase 1 (Jak1 (zeige JAK1 Proteine)) degradation is dependent on Nedd4 family interacting proteins Ndfip1/Ndfip2 (zeige NDFIP2 Proteine).

  2. Silencing of Ndfip1 inhibited cytokine-induced apoptosis of pancreatic islets and promoted glucose-stimulated insulin (zeige INS Proteine) secretion. These effects were associated with an increase in the cellular content of JunB (zeige JUNB Proteine), a potent inhibitor of ER stress and apoptosis.

  3. transgene expression of Ndfip1 in the developing brain increased nuclear Pten and lengthened the cell cycle of neuronal progenitors, resulting in microencephaly.

  4. It attenuates 6-OHDA-induced iron accumulation via regulating the degradation of DMT1 (zeige SLC11A2 Proteine).

  5. The results of this study indicated that Ndfip1, through its Nedd4 effectors, is important for the development of dendrites and dendritic spines in the cortex

  6. Ndfip1 is required during stress for ubiquitinating and trafficking BRAT1 (zeige C7orf27 Proteine) into the nucleus.

  7. Ndfip1 regulates itch ligase activity and airway inflammation via UbcH7 (zeige UBE2L3 Proteine).

  8. Genomic deletion of Ndfip1 abrogated nuclear trafficking of ubiquitinated Pten, even in the presence of Rab5 (zeige RAB5A Proteine).

  9. Iron status and lipopolysaccharide regulate Ndfip1 by activation of nuclear factor-kappa B.

  10. Ndfip1 deficiency precipitated autoimmune pancreatic destruction and diabetes; however, this depended on a further accumulation of nontolerant anti-self T cells from strong stimulation by exogenous tolerogen

NDFIP1 Protein Überblick

Protein Überblick

The protein encoded by this gene belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins.

Alternative names and synonyms associated with NDFIP1

  • Nedd4 family interacting protein 1 (ndfip1)
  • Nedd4 family interacting protein 1 (NDFIP1)
  • Nedd4 WW domain-binding protein 5 (n4wbp5)
  • Nedd4 family interacting protein 1 (Ndfip1)
  • 0610010M22Rik Protein
  • MGC108163 Protein
  • N4wbp5 Protein
  • NDFIP1 Protein
  • wu:fc17e11 Protein
  • zgc:55546 Protein

Bezeichner auf Proteinebene für NDFIP1

Nedd4 WW binding protein 5 , Nedd4 family interacting protein 1 , Nedd4 WW domain-binding protein 5 , NEDD4 family-interacting protein 1 , breast cancer-associated protein SGA-1M , putative MAPK-activating protein PM13 , putative NF-kappa-B-activating protein 164 , putative NFKB and MAPK-activating protein , NEDD4 WW domain-binding protein 5 , Nedd4 WW-binding protein 5

GENE ID SPEZIES
324047 Danio rerio
416342 Gallus gallus
613097 Xenopus (Silurana) tropicalis
100036827 Xenopus laevis
462156 Pan troglodytes
100136080 Oncorhynchus mykiss
80762 Homo sapiens
478044 Canis lupus familiaris
541196 Bos taurus
65113 Mus musculus
291609 Rattus norvegicus
100726594 Cavia porcellus
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