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anti-FBXL5 (FBXL5) Antikörper

Bezeichnung:: anti-F-Box and Leucine-Rich Repeat Protein 5 Antikörper (FBXL5)

Auf www.antikoerper-online.de finden Sie aktuell 67 F-Box and Leucine-Rich Repeat Protein 5 (FBXL5) Antikörper von 20 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen FBXL5 Kits (12) und FBXL5 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 89 FBXL5 Produkte verfügbar.

Synonyme:: Fbl4, FBL5, FBXL5, Fir4, FLR1, MGC53238, wu:fb52d06

Alle Antikörper anzeigen	Gen	GeneID	UniProt
	FBXL5	26234	Q9UKA1
	FBXL5	242960	Q8C2S5
	FBXL5	305424
Alle Spezies anzeigen Weitere Synonyme anzeigen

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anti-Human FBXL5 Antikörper:

anti-Mouse (Murine) FBXL5 Antikörper:

anti-Rat (Rattus) FBXL5 Antikörper:

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Verknüpfte Pathways mit anti-FBXL5 Antikörper

Transition Metal Ion Homeostasis

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Weitere Antikörper gegen FBXL5 Interaktionspartner

Human F-Box and Leucine-Rich Repeat Protein 5 (FBXL5) Interaktionspartner

this study demonstrated that FBXL5 functioned as an oncogene in the progression of colon cancer through regulating PTEN/PI3K/AKT signaling
Transcriptomic analysis shows downregulation of FBXL5 expression in HSCs of patients with myelodysplastic syndrome.
regulatory circuit involving FBXL5 and CIA acts through both IRPs to control iron metabolism and promote optimal cell growth
analysis of the redox sensing mechanism by which FBXL5 can serve as an iron metabolism regulator within mammalian cells
FBXL5 regulates cortactin through induction of its ubiquitylation, and FBXL5 similarly regulates Snail1.
FBXL5-mediated degradation of CITED2 leads to the activation of HIF-1alpha.
results thus suggest that HERC2 regulates the basal turnover of FBXL5, and that this ubiquitin-dependent degradation pathway contributes to the control of mammalian iron metabolism
F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis
Data indicate that F-box and leucine-rich repeat protein 5 (FBXL5)-Hr (hemerythrin-like domain) undergoes substantive structural changes when iron becomes limiting, accounting for its switch-like behavior.
Detailed molecular and structural characterization of the ligand-responsive hemerythrin domain provides insights into the mechanisms by which FBXL5 serves as a unique mammalian metabolic sensor.
iron homeostasis is regulated by a proteolytic pathway that couples IRP2 degradation to intracellular iron levels through the stability and activity of FBXL5
observations suggest a mechanistic link between iron sensing via the FBXL5 hemerythrin domain, IRP2 regulation, and cellular responses to maintain mammalian iron homeostasis
Our findings provide a potential mechanism by which p150(Glued) protein function is regulated by SCFs.

Mouse (Murine) F-Box and Leucine-Rich Repeat Protein 5 (FBXL5) Interaktionspartner

Conditional deletion of Fbxl5 in mouse HSCs results in cellular iron overload and a reduced cell number. Bone marrow transplantation reveals that FBXL5-deficient HSCs are unable to reconstitute the hematopoietic system of irradiated recipients as a result of stem cell exhaustion. Transcriptomic analysis shows abnormal activation of oxidative stress responses and the cell cycle in FBXL5-deficient mouse HSCs.
FBXL5 contributes to regulation of neural stem progenitor cell proliferation during mammalian brain development.
we describe the iron and oxygen sensing mechanisms of the FBXL5 Hr-like domain and its role in mediating ROS biology.
F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis
The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo.

FBXL5 Antigen-Profil

Beschreibung des Gens

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternatively spliced transcript variants have been described for this locus.

Alternative names and synonyms associated with FBXL5

F-box and leucine rich repeat protein 5 (FBXL5) Antikörper
F-box and leucine-rich repeat protein 5 S homeolog (fbxl5.S) Antikörper
F-box and leucine-rich repeat protein 5 L homeolog (fbxl5.L) Antikörper
F-box and leucine-rich repeat protein 5 (fbxl5) Antikörper
F-box and leucine-rich repeat protein 5 (Fbxl5) Antikörper

Fbl4 Antikörper
FBL5 Antikörper
FBXL5 Antikörper
Fir4 Antikörper
FLR1 Antikörper
MGC53238 Antikörper
wu:fb52d06 Antikörper

Bezeichner auf Proteinebene für FBXL5

F-box and leucine-rich repeat protein 5 , F-box/LRR-repeat protein 5 , F-box/LRR-repeat protein 5-like , F-box protein FBL4/FBL5 , F-box protein FBL5 , p45SKP2-like protein

GENE ID	SPEZIES
479085	Canis lupus familiaris
100511143	Sus scrofa
422829	Gallus gallus
380440	Xenopus laevis
432131	Xenopus laevis
461125	Pan troglodytes
496483	Xenopus (Silurana) tropicalis
100012405	Monodelphis domestica
100074228	Ornithorhynchus anatinus
100173556	Pongo abelii
100351566	Oryctolagus cuniculus
100388303	Callithrix jacchus
100605502	Nomascus leucogenys
26234	Homo sapiens
519695	Bos taurus
242960	Mus musculus
305424	Rattus norvegicus
322181	Danio rerio
101106171	Ovis aries

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