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The zebrafish-metastasis model confirms that the ARF1 gene depletion suppresses breast cancer cells to metastatic disseminate throughout fish body.
ARF1 is a critical regulator in prostate cancer progression
our findings demonstrate that ARF1 is a molecular switch for cancer progression and thus suggest that limiting the expression/activation of this GTPase (zeige RACGAP1 Proteine) could help improve outcome for breast cancer patients.
changes in distinct lipid ratios may converge on ARF1 to increase SBP-1/SREBP-1 (zeige SREBF1 Proteine) activity.
Experiments using a mutant form of ARF1 affecting GTP (zeige AK3 Proteine) hydrolysis suggest that ARF1[GTP (zeige AK3 Proteine)] is functionally required for the tubules to form.
ARNO-ARF1 regulates formation of podosomes by inhibition of RhoA/myosin-II and promotion of actin core assembly.
Activation of ARF1 dissociates ADRP (zeige PLIN2 Proteine) from lipid droplets. A constitute active form of ARF1 (ARF1Q71I) promotes HCV assembly. ADRP (zeige PLIN2 Proteine) played a positive role in Hepatitis C virus replication and negative role in Hepatitis C virus assembly.
ARF1 may reverse CAM-DR by regulating phosphorylation of p27 (zeige PAK2 Proteine) at T157 in MM. our data shed new light on the molecular mechanism of CAM-DR in MM, and targeting ARF1 may be a novel therapeutic approach for improving the effectiveness of chemotherapy in MM.
We report here that 2-methylcoprophilinamide (M-COPA (zeige COPA Proteine)), a compound that induces disassembly of the Golgi apparatus by inactivating ADP-ribosylation factor 1 (Arf1), suppresses Stx (zeige ST8SIA2 Proteine)-induced apoptosis. M-COPA (zeige COPA Proteine) inhibited transport of Stx (zeige ST8SIA2 Proteine) from the plasma membrane to the Golgi apparatus and suppressed degradation of anti-apoptotic proteins and the activation of caspases
observations indicate that Arf1 and Arf3 (zeige ARF3 Proteine) as well as Arf6 (zeige ARF6 Proteine) play important roles in cytokinesis.
The authors found that Arf1 occupies contrasting molecular environments within the Coat Protein (zeige GOLPH3 Proteine) Complex I, leading them to hypothesize that some Arf1 molecules may regulate vesicle assembly while others regulate coat disassembly.
ARF1 may be a plausible inter-player that mediates the transition to osteoclast fusion at multiple steps during osteoclast differentiation.
Increased gene dosage of Ink4a, Arf1 and p53 (zeige TP53 Proteine) delays age-associated central nervous system functional decline.
ARF1/TBCE (zeige TBCE Proteine)-mediated cross-talk that coordinates COPI formation and tubulin (zeige TUBB Proteine) polymerization at the Golgi.
These data establish for the first time that the Arf1 gene is indispensable for mouse embryonic development after implantation.
Arf modulates LRP6 (zeige LRP6 Proteine) phosphorylation for the transduction of Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling.
Down-regulation of ADP-ribosylation factor results in corneal neovascularization regression.
ARF1-dependent trafficking of procathepsin B and the maturation of autophagosomes results in cathepsin B-mediated trypsinogen activation induced by caerulein.
Egr1 mediates p53-independent c-Myc-induced apoptosis via a noncanonical ARF-dependent transcriptional mechanism
A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling
findings reveal a novel signalling pathway involved in development of the semicircular canal system, and suggest a previously unrecognized role for NCS-1 (zeige NCS1 Proteine) in mitochondrial function via its association with several mitochondrial proteins.
Vascular endothelial growth factor receptor-2 (zeige KDR Proteine) activates ADP-ribosylation factor 1 to promote endothelial nitric-oxide synthase (zeige NOS3 Proteine) activation and nitric oxide release from endothelial cells
Data show that AP-1 (zeige JUN Proteine) recruitment to the cell membrane was found to be dependent on myristoylated ADP-ribosylation factor (ARF1), GTP (zeige AK3 Proteine) or nonhydrolyzable GTP (zeige AK3 Proteine)-analogs, tyrosine signals, and small amounts of phosphoinositides.
NCS-1 (zeige NCS1 Proteine)-ARF1 interaction provides evidence for functional cross-talk between Ca(2 (zeige CA2 Proteine)+)-dependent and ARF-dependent pathways in TGN (zeige TG Proteine) to plasma membrane traffic
The ARF1 machinery also might produce movement- and fission-promoting forces through actin polymerization.
Binding of cargo signal peptides to AP-1 (zeige JUN Proteine) induces a conformational change in its core domain that greatly enhances its interaction with Arf-1-GTP (zeige AK3 Proteine).
Study shows that ARF DNA-binding domains ahomodimerize to generate cooperative DNA binding, which is critical for in vivo ARF5 (zeige ARF5 Proteine)/MP function. Strikingly, DNA-contacting residues are conserved between ARFs, and found that monomers have the same intrinsic specificity; ARF1 and ARF5 (zeige ARF5 Proteine) homodimers, however, differ in spacing tolerated between binding sites.
Data indicate that ArfGAP domain8 (AGD8) and ARF-GAP domain 9 (AGD9), are involved in the recruitment of Arf1-GDP to the Golgi apparatus .
ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
ADP-ribosylation factor 1
, adp-ribosylation factor 1
, ADP-ribosylation factor domain protein 1