anti-Aconitase 1 (ACO1) Antikörper

Mouse (Murine) Aconitase 1 (ACO1) Interaktionspartner

1. IL-6 likely up-regulates IRP1 and DMT1 expression and down-regulates FPN1 expression in BV2 microglial cells through JNK signaling pathways

2. Using whole RNA sequencing of bone marrow cells in iron-overloaded mice, it was observed that Idh1 and Aco1, enzymes involved in the TCA cycle, were elevated.

3. The Irp1-/- mice develop polycythemia and pulmonary hypertension, and suggesting that Irp1 plays an essential role in erythropoiesis and in the pulmonary and cardiovascular systems.

4. IRP1 and IRP2 mutant mice rapidly succumb to systemic infection with Salmonella Typhimurium, a pathogenic bacterium that multiplies within macrophages, with increased bacterial burdens in liver and spleen.

5. results uncover an unexpected protective role of IRP1 in pathological conditions associated with altered Fe-S metabolism

6. Aco1 KD in fully differentiated 3T3-L1 adipocytes decreased lipogenic, Idh1, Adipoq, and Glut4 gene expression.

7. impaired mitochondrial [Fe-S] cluster biogenesis in Mfrn1(gt/gt) cells results in elevated IRP1 RNA-binding that attenuates ALAS2 mRNA translation and protoporphyrin accumulation

8. Data indicate that JTR-009, a benzimidazole, operated by preventing iron-regulatory protein-1 (IRP1) from binding to the iron-responsive element (IRE) in APP mRNA.

9. Human ACO1 is a moonlighting protein that has both aconitase enzyme activity as well as an mRNA binding function.

10. Aco1 is a moonlighting protein that has aconitase activity as well as mRNA binding ability.

11. IRP1 is the principal regulator of HIF2alpha mRNA translation

12. Irp1 deletion enhanced HIF2alpha protein expression in kidneys of Irp1(-/-) mice.

13. These results uncover separable physiological roles of each IRP and identify IRP1 as a therapeutic target for manipulating HIF-2alpha action in hematologic, oncologic, and other disorders.

14. The RNA-binding and aconitase forms of IRP-1 can undergo interconversion dependent on the density of cells growing in culture.

15. aconitase functions as a licensing factor in ERK-dependent proliferation and differentiation, thereby providing a regulatory input for iron in EPO-dependent erythropoiesis.

16. A wide network of mRNAs and proteins with iron-dependent regulation, IRP-dependent regulation, or both.

17. Iron regulatory protein 1 outcompetes iron regulatory protein 2 in regulating cellular iron homeostasis in response to nitric oxide.

18. Mice lacking both IRP1 in their hepatocytes suffer from mitochondrial iron deficiency and dysfunction associated with alterations of the ISC and heme biosynthetic pathways, leading to liver failure and death.

19. Iron regulatory protein-1 (Irp1)/aconitase activities studied in macrophages grown under control conditions or subjected to iron starvation or supplementation show that Irp1 is activated by direct disassembly of the Fe-S cluster of cytoplasmic aconitase.

20. A comparative study of the roles of iron regulatory proteins 1 and 2 in regulating iron metabolism.