(Triggering Receptor Expressed On Myeloid Cells 2 (TREM2))
This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012].
TREM2
Spezies: Maus
Wirt: Mammalian Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
TREM2
Spezies: Cynomolgus
Wirt: Mammalian Cells
Recombinant
The purity of the protein is greater than 90 % as determined by SDS-PAGE and Coomassie blue staining.
Woollacott, Nicholas, Heslegrave, Heller, Foiani, Dick, Russell, Paterson, Keshavan, Fox, Warren, Schott, Zetterberg, Rohrer: "Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroup." in: Alzheimer's research & therapy, Vol. 10, Issue 1, pp. 79, (2018) (PubMed).
Jendresen, Årskog, Daws, Nilsson: "The Alzheimer's disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway." in: Journal of neuroinflammation, Vol. 14, Issue 1, pp. 59, (2017) (PubMed).