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the direct effects of S100A12 on human osteoclasts in vitro, were examined.
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serum S100A12 levels were higher in juvenile idiopathic arthritis patients
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S100A12 is differentially expressed in chronic rhinosinusitis subtypes and is significantly elevated in patients with chronic rhinosinusitis with nasal polyps and associated with chronic rhinosinusitis-specific disease severity
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Used fluorescence and NMR spectroscopy to analyze the interaction of S100A9 with S100A12. Binary complex models of S100A9-S100A12 were developed using data obtained from 1H-15N HSQC NMR titrations and the HADDOCK program; overlaid the complex models of S100A9-S100A12 with the same orientation of S100A9 and the RAGE V-domain. Complex showed that S100A12 protein blocks the interaction between S100A9 and the RAGE V-domain.
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S100A12 activates NLPR3 inflammasomes to induce MUC5AC production in airway epithelial cells. ATP induces MUC5AC production in a mechanistically similar mode to S100A12.
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The results suggest that S100A12 does not participate in the induction of inflammation in dental pulp. However, RAGE can participate in the inflammation in the pulp of males.
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S100A12 was a significant predictor of lung alveolar infiltration (OR 2.60, 95%CI 1.35-5.00, p = 0.004). These results suggest that S100A12 has the potential to assess the extent of alveolar infiltration in Pulmonary tuberculosis.
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Results indicated that S100A12 could increase the expression of MMP-2, MMP-9, and vascular cell adhesion molecule 1 (VCAM-1) in HASMCs via activation of ERK1/2 signal pathway, which leads to injury of HASMCs.
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S100A12 binds to CD36 in the low nanomolar range at the CD36 thrombospondin-1 binding site.
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data on the antimicrobial activity of S100A12 have been reported. Proinflammatory role of S100A12 is supported by another newly found receptor, Toll-like receptor 4 (TLR4).
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Report role of fecal S100A12 assay in the diagnosis and management of inflammatory bowel disease.
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The aim of this mini-review was to outline the pleiotropic actions of S100A12 and to highlight the potential clinical importance of this protein in kidney and cardiovascular diseases. [review]
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serum levels had significant, positive correlations with intensive care unit length of stay, 28-day mortality, and in-hospital mortality after major abdominal surgery
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Elevated S100A8 and S100A9 gene expression in SP-infected HMEECs and in the middle ear mucosa of OM, minor co-localized with neutrophil markers suggests that middle ear epithelial cell secretion of S100A8 and S100A9 may play a role in the pathogenesis of recurrent and chronic OM
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Expression of S100A8, S100A9 and S100A12 is modulated by eicosapentaenoic acid and docosahexaenoic acid during Inflammation in adipose tissue and mononuclear cells.
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The binding interface between S100A12 and the V domain of RAGE has been identified and mapped.
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S100A12 functions as a proinflammatory cytokine and activates dermal fibroblasts, causing dermal fibrosis
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S100A9 and S100A12 may have a role in the pathogenesis of pneumonia: S100A9 and CXCL1 may contribute solely in mild pneumonia, and CCL5 and CXCL11 may contribute in severe pneumonia.
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These data suggest that S100A12 is part of an innate and adaptive inducible antimicrobial network that contributes to host defense against mycobacteria in infected macrophages
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Among the investigated S100-proteins, S100A12 showed the closest association with disease activity and therapeutic response and might therefore provide a valuable biomarker for psoriasis
