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anti-Human TLR3 Antikörper:
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Dog (Canine) Monoclonal TLR3 Primary Antibody für FACS, ICC - ABIN4360082
Wen, Peng, Li, Wong: The effect of innate immunity on autoimmune diabetes and the expression of Toll-like receptors on pancreatic islets. in Journal of immunology (Baltimore, Md. : 1950) 2004
Show all 65 Pubmed References
Dog (Canine) Monoclonal TLR3 Primary Antibody für FACS - ABIN4360083
Funami, Matsumoto, Oshiumi, Akazawa, Yamamoto, Seya: The cytoplasmic 'linker region' in Toll-like receptor 3 controls receptor localization and signaling. in International immunology 2004
Show all 25 Pubmed References
Dog (Canine) Monoclonal TLR3 Primary Antibody für FACS, ICC - ABIN4360084
Evangelista, Castro, Alves, Dias, Souza, Reis, Silva, Castañon, Farias, Juliano, Ferreira: Early IFN-γ production together with decreased expression of TLR3 and TLR9 characterizes EAE development conditional on the presence of myelin. in Autoimmunity 2016
Show all 24 Pubmed References
Dog (Canine) Monoclonal TLR3 Primary Antibody für ELISA - ABIN4248101
Ranjith-Kumar, Miller, Xiong, Russell, Lamb, Santos, Duffy, Cleveland, Park, Bhardwaj, Wu, Russell, Sarisky, Mbow, Kao: Biochemical and functional analyses of the human Toll-like receptor 3 ectodomain. in The Journal of biological chemistry 2007
Show all 21 Pubmed References
Human Polyclonal TLR3 Primary Antibody für FACS, IHC (fro) - ABIN252527
Patole, Gröne, Segerer, Ciubar, Belemezova, Henger, Kretzler, Schlöndorff, Anders: Viral double-stranded RNA aggravates lupus nephritis through Toll-like receptor 3 on glomerular mesangial cells and antigen-presenting cells. in Journal of the American Society of Nephrology : JASN 2005
Show all 14 Pubmed References
Human Monoclonal TLR3 Primary Antibody für FACS, IF - ABIN2191973
Matsumoto, Kikkawa, Kohase, Miyake, Seya: Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling. in Biochemical and biophysical research communications 2002
Show all 6 Pubmed References
Human Monoclonal TLR3 Primary Antibody für FACS, IF - ABIN2191974
Oshiumi, Matsumoto, Funami, Akazawa, Seya: TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction. in Nature immunology 2003
Show all 6 Pubmed References
Human Monoclonal TLR3 Primary Antibody für FACS, IF - ABIN2191972
Matsumoto, Funami, Tanabe, Oshiumi, Shingai, Seto, Yamamoto, Seya: Subcellular localization of Toll-like receptor 3 in human dendritic cells. in Journal of immunology (Baltimore, Md. : 1950) 2003
Show all 6 Pubmed References
Human Polyclonal TLR3 Primary Antibody für ICC, IF - ABIN4360085
Hsieh, Chang, Chen, Li, Chuang, Yu, Cheung, Chen, Maa, Leu: The inducible nitric-oxide synthase (iNOS)/Src axis mediates Toll-like receptor 3 tyrosine 759 phosphorylation and enhances its signal transduction, leading to interferon-β synthesis in macrophages. in The Journal of biological chemistry 2014
Show all 6 Pubmed References
Bird (Avian) Polyclonal TLR3 Primary Antibody für FACS, IHC (p) - ABIN4360080
Kuzemtseva, de la Torre, Martín, Soldevila, Ait-Ali, Mateu, Darwich: Regulation of toll-like receptors 3, 7 and 9 in porcine alveolar macrophages by different genotype 1 strains of porcine reproductive and respiratory syndrome virus. in Veterinary immunology and immunopathology 2014
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Positive rates of iNOS (zeige NOS2 Antikörper) in cervical tissues were 72.1%, 28.2%, and 3.1% in the -HPV-positive patients with cervical cancer (CC group), HR-HPV group, and controls, respectively (P < 0.05). Levels of TLR3, TLR4 (zeige TLR4 Antikörper), TLR7 (zeige TLR7 Antikörper), TLR8 (zeige TLR8 Antikörper), NF-kappaB (zeige NFKB1 Antikörper) p65 (zeige GORASP1 Antikörper), and iNOS (zeige NOS2 Antikörper) in cervical epithelial cells were higher in CC group than in other groups.
TLR signaling, in particular TLR3 activation, can efficiently reactivate HIV transcription in infected microglia, but not in monocytes or T cells
This study revealed that TLR2 rs3804100 and TLR3 rs3775291 polymorphisms may be protective factors for HBV-related hepatocellular carcinoma .
TLR3 stimulation induces the Warburg effect in head and neck squamous carcinoma cells in vitro, and suggest that TLR3 may play a role in tumor adaptation to hypoxia.
we report that autophagy is associated with apoptosis processes, involving LC3 (zeige MAP1LC3A Antikörper) and TRIF (zeige TRIM69 Antikörper)-colocation in human HCC (zeige FAM126A Antikörper) cells. Regulation of autophagy and the TLR3-TRIF (zeige TRIM69 Antikörper) pathway may be effective in the treatment of liver cancer.
Polymorphism of CD209 (zeige CD209 Antikörper) and TLR3 genes in populations of North Eurasia
TLR3-activated signaling enhanced the therapeutic effects of human umbilical cord-derived mesenchymal stem cells in a mouse model of colitis
the TLR3 Leu412Phe CC genotype is independently associated with severity of hepatitis C recurrence after LT.
These data demonstrate that in the absence of HBsAg, hepatic hepatitis B virus replication leads to Tlr3-dependent interferon (zeige IFNA Antikörper) responses in non-parenchymal liver cells.
Study found that the astrocytic TLR3-mediated cytokine expression profile is modulated by prostaglandin, and NF-kappaB (zeige NFKB1 Antikörper), ERK1/2 and GSK-3beta are involved in the modulatory mechanism. These results suggest that pathological conditions with increased COX (zeige COX8A Antikörper) activity can neuroimmunologically alter neuron-glia interaction.
TLR3 signaling contributes to Wallerian degeneration after peripheral nerve injury by affecting Schwann cell activation.
This study establishes a correlation between TLR-3 and TLR-9 (zeige TLR9 Antikörper) expression with the development of EAE. In addition, evidence of a role for the myelin peptide in targeting the innate inflammatory response to the CNS is presented.
Data show that HCFC2 (zeige HCFC2 Antikörper) is a critical component of the IRF1 (zeige IRF1 Antikörper) and IRF2 (zeige IRF2 Antikörper) transcriptional machinery that regulates Tlr3 gene expression.
the JAK (zeige JAK3 Antikörper)-STAT (zeige STAT1 Antikörper) pathway provides a cytokine rheostat mechanism, which enables macrophages to fine-tune their responses to multiple, temporally separated infection events involving the TLR3 and TLR7 (zeige TLR7 Antikörper) pathways.
These results suggest that testicular innate immune responses to pathogens caused by nano-TiO2 may be involved in the regulatory mechanisms of TAM (zeige CCNA1 Antikörper)/TLR3 signaling in testicular Sertoli cells.
findings report that RKIP (zeige PEBP1 Antikörper) preferentially regulates the TLR3-mediated immune response in macrophages; phosphorylation of RKIP (zeige PEBP1 Antikörper) serine 109 is required for RKIP (zeige PEBP1 Antikörper) to promote TLR3-mediated signaling and inflammation
Furthermore, Leishmania RNA virus 1-induced TLR-3 activation promoted parasite persistence by enhancing macrophage survival through Akt (zeige AKT1 Antikörper) activation in a manner partially dependent on miR (zeige MLXIP Antikörper)-155.
Primary tumor-derived exosomal RNAs, which are enriched in small nuclear RNAs, activate TLR3 in lung epithelial cells, consequently inducing chemokine (zeige CCL1 Antikörper) secretion in the lung and promoting neutrophil recruitment.
Autophagy contributes to macrophage resistance to Leishmania major. Data, including data from studies in knockout mice, suggest a key resistance mechanism involves endosomal signaling via Tlr3/7/9 in macrophages; macrophages deficient for Tlr3/7/9, Unc93b1 (zeige UNC93B1 Antikörper), or MyD88 (zeige MYD88 Antikörper) fail to undergo L. major-induced autophagy. (TLR = Toll (zeige TLR4 Antikörper)-like receptor; Unc93b1 (zeige UNC93B1 Antikörper) = unc-93 (zeige UNC93B1 Antikörper) homolog B1; MyD88 (zeige MYD88 Antikörper) = myeloid differentiation primary response gene 88 (zeige MYD88 Antikörper))
Our study reveals a novel mechanism of TLR3 in regulation of dendritic morphology and provides an explanation for how environmental factors influence mental health.
These data demonstrated that TLR2, TLR3 and TLR9 (zeige TLR9 Antikörper) contribute to NF-kappaB (zeige NFKB1 Antikörper) activation in response to porcine epidemic diarrhea virus infection, but not RIG-I (zeige DDX58 Antikörper).
TLR3 is regulated differentially by different genotype 1 PRRSV strains and this seems to be related apparently to the replication levels of each strain, as well as, to the TNF-alpha (zeige TNF Antikörper) inducing capability.
5 known non-synonymous single nucleotide polymorphisms (SNPs) were characterized in the coding sequences of the porcine TLR3 gene.
Activation of porcine TLR3 signaling is important in stimulating effective responses to PRRSV infection.
The results from this study demonstrate that expression of at least TLR3, TLR7 (zeige TLR7 Antikörper) and TLR8 (zeige TLR8 Antikörper) is stimulated upon bovine alpha-herpesvirus infection of the brain.
TLR2, 3, 4, and 8 mRNA expression is strongly upregulated and correlates with the progression of atherosclerosis in the aorta. Fluvastatin significantly inhibited this progress and reduced inflammation via TLR downregulation.
18 SNPs of TLR3 were observed and only 4 polymorphic positions were detected in the domestic breeds and 14 non-synonymous substitutions were observed, most of them in the LRR molecules.
Differential gene expression following TLR stimulation in rag1 (zeige RAG1 Antikörper)-/- mutant zebrafish tissues and morphological descriptions of lymphocyte-like cell populations
Binding energy (BE) calculation using MM/PBSA method from the TLR3- and TLR22-ligand complexes revealed an adequate binding affinity between TLR22-monomer and dsRNA as like as TLR3-dimer-dsRNA complex.
Full-length tlr3 was functionally characterized.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.
toll-like receptor 3
, toll-like receptor 3-like
, toll-like receptor 3 variant 1