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anti-Human TLR2 Antikörper:
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Mouse (Murine) Monoclonal TLR2 Primary Antibody für Func, IA - ABIN2191804
Meng, Rutz, Schiemann, Metzger, Grabiec, Schwandner, Luppa, Ebel, Busch, Bauer, Wagner, Kirschning: Antagonistic antibody prevents toll-like receptor 2-driven lethal shock-like syndromes. in The Journal of clinical investigation 2004
Show all 6 Pubmed References
Mouse (Murine) Monoclonal TLR2 Primary Antibody für Func, IA - ABIN2191805
Roura-Mir, Wang, Cheng, Matsunaga, Dascher, Peng, Fenton, Kirschning, Moody: Mycobacterium tuberculosis regulates CD1 antigen presentation pathways through TLR-2. in Journal of immunology (Baltimore, Md. : 1950) 2005
Show all 5 Pubmed References
the expression levels of Toll-like receptors 2 (TLR2) and 4 (TLR4) in monocytes and neutrophils from patients with Keratoconus, are reported.
In adult patients with shingles, genotype AA of gene Toll-like receptor 2 was associated with a high risk of Varicella-Zoster virus reactivation and manifestation of herpes zoster, moderate course.
this study shows enhanced TLR2 responses in multiple sclerosis
Taken together, oxidative stress upregulates expression of TLR2/4, IRF3/5 and signature proinflammatory cytokines in peripheral blood mononuclear cells, involving MAPK/NF-kappaB dependent signaling, all of which may have implications for metabolic inflammation.
Low b-cell TLR2 expression is associated with poor prognosis in patients with chronic lymphocytic leukemia.
We found associations between polymorphisms in TLR2 and TLR4 and risk of colorectal cancer.
The expression of TLR2 and TLR4 and the incidence of SIBO [small intestinal bacterial overgrowth] in HCC [ hepatocellular carcinoma ] patients are significantly higher than cirrhosis and healthy control group. Moreover, the high expressions of TLR2 and TLR4 in SIBO-positive HCC patients may promote the development of HCC.
TLR2 Arg753Gln polymorphism is significantly associated with high tuberculosis risk.
Our meta-analysis revealed a novel finding that the heterogeneous "GA" genotype of the TLR2 rs5743708 and "AG" genotype of the TLR4 rs4986790 may be associated with increased susceptibility to atopic dermatitis in Caucasians.
Study found that TLR2 expression was positively correlated with the progression and grade of glioma. Its pro-cancer effects were associated with autophagic flux which is linked to activation of p38 MAPK. These findings may provide a novel immune regulatory mechanism, which links TLR2 and induction of autophagy in glioma cells.
Among infants, an HSP90B1 gene-region variant is associated with BCG-induced IL-2 production and may be associated with protection from TB disease. HSP90B1 knockdown in human monocyte-like cell lines did not influence TLR2 surface localization nor Mtb replication. Together, these data suggest that HSP90B1 regulates T-cell, but not monocyte, responses to mycobacteria in humans.
Intracellular IFN-gamma production upon stimulation with TLR2 and TLR9 ligands.
These results reveal that vesicle release by bacterium-derived surfactants is required for TLR2-mediated inflammation
TLR4 rs10759932, but not TLR2 rs3804099 and rs3804100, was associated with risk of premalignant and/or malignant gastric cancer and H. pylori susceptibility.
Expression levels of TLR2 and TLR4 were associated with age. In particular, we observed that their expression increased during the suckling period and then clearly decreased once the infants reached 1 year of age.
The results further confirm that LipL32 interacts with TLR2 through Nbeta1beta2 and Calpha4 domains of LipL32 as well as LipL32-TLR2 complex formation results from hydrophobic interactions.
Expression of neutrophil TLR2, TLR4 and CD64 is increased in pulmonary tuberculosis patients.
Studied association of toll like receptor 2 (TLR2) single nucleotide polymorphisms (SNPs) with tuberculosis susceptibility in a Chinese population.
In a cohort of 114 Greek COPD patients, we confirmed that the presence of TLR4-D299G or TLR4-T399I SNPs was significantly associated with an earlier COPD stage (p = 0.003 and p = 0.009, respectively). In comparison, the absence of any analyzed polymorphism, including those of TLR2-R753Q and genotypic MBL deficiency, was associated with a more severe disease phenotype, characterized by more frequent exacerbation.
DHX9 suppression in these cells phenocopied the effects of E3 expression on TLR2- and TLR8-dependent cytokine induction, in that DHX9 was required for all TLR8-dependent cytokines measured, and for TLR2-dependent IL-6.
dual TLR2/9 recognition plays a critical role in providing resistance against mucosal infection with HSV
These results suggest that urban atmospheric particulate matter less than 2.5mum in diameter (PM2.5) may exacerbate allergic inflammation in the murine lung via a TLR2/TLR4/MyD88-signaling pathway. PM2.5-bound trace microbial elements, such as lipopolysaccharide may be a strong candidate for exacerbation of murine lung eosinophilia.
diabetes-induced cardiac dysfunction could be attenuated by TLR2 knockout.
Contact hypersensitivity immune response was markedly increased in TLR2-deficient or TLR9-deficient NOD mice.
the functional activity of TLR2, cluster of differentiation 14 (CD14), and myeloid differentiation primary response gene 88 (MyD88) molecules in the recognition of C. albicans by gingival fibroblast, was investigated.
Mycobacterium tuberculosis LprG, LAM, and LM were all found to bind to TLR2 in the absence of TLR1, but not to TLR1 in the absence of TLR2.
Light Guided In-vivo Activation of Innate Immune Cells with Photocaged TLR 2/6 Agonist.
TLR2 on BM-derived leukocytes is involved in the response of the heart to sustained pressure overload. TLR2 deficiency does not affect hypertrophy but reduces fibrosis and protects from cardiac systolic and diastolic dysfunction.
It findings indicate that core fucose is essential for CD14-dependent TLR4 and TLR2 signalling in murine macrophage activity, leading to DSS-induced experimental colitis.
LpqT inhibited M. smegmatis induced TLR2-mediated inflammatory cytokine expression and cell apoptosis in macrophages, thus supported mycobacteria intracellular survival.
Low TLR2 expression is associated with cardiac dysfunction.
TLR2 orchestrates glia activation during gray and white matter demyelination.
TLR2 induced the expansion of Kupffer Cells, which are essential for the strengthened T cell suppression by TLR2-stimulated intrahepatic myeloid-derived cells.
The liver injury resulting from virus (adenovirus) or chemicals (CCl4) could induce an amplified (stronger/long-lasting) hepatic inflammation by releasing the ligands for TLR2/TLR4.
TLR-2 signalling appears to be important in the innate immune response against Sporothrix brasiliensis.
ES antigen-induced M2b polarization was found to be dependent on enhanced NF-kappaB signaling mediated by the MyD88/MAPK pathway in a TLR2-dependent manner.
In summary, we have demonstrated that the C-terminal tail of HMGB1 negatively regulates the interaction with TLR2.
PPE60 induces Th1 and Th17 immune responses by activating DCs in a TLR2-dependent manner, suggesting PPE60's potential for use in MTB vaccine development
The expression of TLR2 and MUC2 in HT-29 cells was up-regulated in stimulation with the exosomes of Gymnophalloides seoi.
These findings further validated the involvement of P. acnes in the pathology of intervertebral disc degeneration (IVDD) and provided evidence that P. acnes-induced apoptosis of NPCs via the TLR2/JNK pathway is likely responsible for the pathology of IVDD
SNPs rs8193046 and rs8193060 are likely a potential marker against Mycobacterium avium subspecies paratuberculosis and a selection programme eliminating AG genotype for rs8193046 and CT genotype for rs8193060 might be beneficial in conferring resistance to Mycobacterium avium subspecies paratuberculosis in Indian cattle population
results suggest that polymorphisms in the TLR2 gene might not play a significant role in the BTB risk in Chinese Holstein cattle
Transcription levels of TLR2, TLR4, and CD14 in Holstein cows with retained placenta significantly decreased between the first and the seventh day postpartum.
We structurally defined with 5'-RACE experiments three promoters (P1-3) controlling TLR2 expression in udder, liver and other tissues of cows suffering from E. coli mastitis.
TLR2 and TLR4 mediate innate response against Cryptosporidium parvum in bovine intestinal epithelial cells.
positive correlation between lower neutrophil apoptosis and higher expression of TLR2 and TLR4 with the formation of NETs and change in surface architecture.
TLR2, TLR1, and TLR6 haev roles in innate immunity and initiate inflammatory responses to bacterial lipopeptides by epithelial and stromal cells of bovine endometrium
Data suggest that granulosa cells from dominant follicles express functional TLR2 and TLR4; granulosa cells appear to participate in innate immunity by responding to bacterial lipopolysaccharides/lipopeptides via TLR2 and TLR4 signaling pathways.
The expressions of host TLR2 and 4 genes were significantly higher in acidosis-resistant steers compared to those in acidosis-susceptible steers.
Whereas previous results regarding the TLR1 gene were not corroborated, a risk haplotype was detected in TLR2; however, its low frequency indicates that this detected association should be interpreted with caution.
The identification of antibodies specific for bovine and ovine TLR2 will facilitate studies of the role of this important pattern recognition receptors in the initiation of immune responses to important pathogens.
ALOX5AP, CPNE3, IL1R2, IL6, TLR2, TLR4, and THY1 were upregulated in blood polymorphonuclear cells in negative energy balance versus positive energy balance cows.
This study showed that TLR1 and TLR2 together are necessary for the recognition of triacylated lipopeptides.
The functional studies suggest that genetic polymorphisms in bovine TLR2 which result in higher macrophage activity may contribute to enhanced T cell activation and a lower susceptibility to paratuberculosis in cattle.
fine mapping of bovine toll-like receptor 4 and toll-like receptor 2 regions
mRNA abundances of TLR9, TLR2, and TLR4 together with those of beta-defensin 5 (BNBD5), an early bactericidal effector molecule of the innate system, in healthy and infected mammary glands
Microcrystals of calcium pyrophosphate dihydrate and monosodium urate use TLR2-mediated signaling in chondrocytes to trigger NO generation.
both S. aureus and E. coli pathogens activate equally well bovine TLR2 and TLR4 receptors to induce NF-kappaB activation
This study indicates that SNP c.3020A>T might play a role in the host response against mastitis and further detailed studies are needed to understand its functional mechanisms.
A combined linkage and linkage disequilibrium method was used to investigate possible associations between the TLR2 and THR4 genes and mastitis susceptibility recorded in the Norwegian Red cattle population.
these results indicate clear responses of porcine neonatal antigen presenting cells after TLR2 and TLR9 stimulation
we assume that reduced TLR2 expression may be responsible for the decreased phagocytizing capacity of circulating monocytes in the early post-traumatic phase
Toll-like receptor 2 signaling on intestinal epithelial cells may enhance intestinal barrier function and prevent deoxynivalenol-induced barrier dysfunction of epithelial cells.
These results suggest that porcine circovirus 2 induces IL-8 secretion via the TLR2/MyD88/NF-kappaB signalling pathway.
At 14 days after autotransplantation of a pig kidney, mRNA expression for TLR2 is increased.
These data demonstrated that TLR2, TLR3 and TLR9 contribute to NF-kappaB activation in response to porcine epidemic diarrhea virus infection, but not RIG-I.
Data suggest TLR2, TLR4, and calcium signaling in enterocytes play principal roles in mucosal immunity against enterotoxigenic Escherichia coli; probiotic Lactobacillus delbrueckii and its extracellular polysaccharides appear to stimulate TLR2/TLR4.
TLR2 is required for the suppression of TLR4 signaling activation.
The role of TLR2, TLR4 and RP105/MD1 in the immunoregulatory effect of acidic exopolysaccharides from Lactobacillus plantarum N14, is reported.
Single nucleotide polymorphisms in TLR2 is associated with immune response to gram-negative bacterial infections.
The dramatic reduction in p38 MAPK phosphorylation by TLR-2 stimulation in aortic valve interstitial cells excludes a role for this receptor type in mediating angiotensin II or peroxynitrite effects.
In total, 20, 27, and 26 SNPs were detected in TLR1, TLR2, and TLR6, respectively; in TLR1 and TLR2, the numbers of SNPs detected were significantly lower (P < or = 0.05, P < or = 0.01) in the wild boars than in the domestic pigs.
both TLR2 and TLR6 are important in the recognition of M. hyopneumoniae in porcine alveolar macrophages
suggest that TLR2 plays an important role in ligand-specific transcytosis and transport in M cells
The expression of TLR2 in monocytes, macrophages, granulocytes, peripheral blood lymphocytes, and epithelial cells of multiple organ systems is reported.
Diet affects the expression of the TLR2-encoding gene.
TLR2, 3, 4, and 8 mRNA expression is strongly upregulated and correlates with the progression of atherosclerosis in the aorta. Fluvastatin significantly inhibited this progress and reduced inflammation via TLR downregulation.
Lipopolysaccharide upregulates the expression of rabbit TLR2 and 4 in the uterine body and horn, and the expression of TLR4 in the ovary.
VB-201 may counter inflammation where TLR-2 and/or CD14 complicity is essential, and is therefore beneficial for the treatment of atherosclerosis.
expression of TLR 2, 4 and 6 as transcript and protein in the placenta (chorioallantois) of 14 foals born alive
This study provides the basis for comparative investigations into the impact of different stimuli on the cellular expression of TLRs 2, 4 and 6 in order to find out if TLRs are involved in the pathogenesis of endometrial diseases and may help to understand as to why some mares develop persistent endometritis.
expression of TLR4 and TLR2 in normal and LPS-treated horses
Because factors other than mastitis can affect SCC and our sample sizes were limited, additional studies are needed to corroborate an association between TLR2 genotype and SCC or mastitis in goats.
Over-expression of TLR2 decreases radical damage to host cells through low-level production of NO and MDA and promotes the clearance of invasive bacteria by up-regulating lysozyme secretion and filtration of inflammatory cells to the infected site.
Cerebrospinal fluid soluble TLR2 and TLR4 may play a role in HIV/SIV-related neuroinflammation and subsequent neuropathology.
TLR2 of M. fuscata has undergone purifying selection while the membrane-proximal part of the extracellular domain of M. mulatta TLR2 exhibits higher rates of non-synonymous substitutions, indicating a trace of Darwinian positive selection
The results indicate that microglia and astrocytes respond to B. burgdorferi through TLR1/2 and TLR5.
Differential gene expression following TLR stimulation in rag1-/- mutant zebrafish tissues and morphological descriptions of lymphocyte-like cell populations
Our studies show that Pam3CSK4 and flagellin can stimulate the Tlr2 and Tlr5 signaling pathways leading to common and specific responses in the zebrafish embryo system.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB.
toll/interleukin 1 receptor-like 4
, toll/interleukin-1 receptor-like protein 4
, toll-like receptor 2 variant 1
, toll-like receptor 2 variant 2
, Toll-like receptor 2-like protein
, toll-like receptor 2