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anti-Human TIRAP Antikörper:
anti-Mouse (Murine) TIRAP Antikörper:
anti-Rat (Rattus) TIRAP Antikörper:
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Human Polyclonal TIRAP Primary Antibody für IHC (fro), WB - ABIN550303
Takeda, Kaisho, Akira: Toll-like receptors. in Annual review of immunology 2003
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Human Polyclonal TIRAP Primary Antibody für WB - ABIN550244
Vogel, Fitzgerald, Fenton: TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. in Molecular interventions 2004
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Human Polyclonal TIRAP Primary Antibody für IP, WB - ABIN949800
Nguyen, Kim, Kim, Le, Kim, Kang, Hasegawa, Kanaho, Jou, Lee et al.: Phosphatidylinositol 4-phosphate 5-kinase ? facilitates Toll-like receptor 4-mediated microglial inflammation through regulation of the Toll/interleukin-1 receptor domain-containing adaptor protein ... in The Journal of biological chemistry 2013
Human Polyclonal TIRAP Primary Antibody für IHC, ELISA - ABIN1003283
Janeway, Medzhitov: Innate immune recognition. in Annual review of immunology 2002
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Human Polyclonal TIRAP Primary Antibody für IHC, ELISA - ABIN1003284
ONeill, Fitzgerald, Bowie: The Toll-IL-1 receptor adaptor family grows to five members. in Trends in immunology 2003
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Human Polyclonal TIRAP Primary Antibody für ELISA, WB - ABIN268824
Andreakos, Sacre, Smith, Lundberg, Kiriakidis, Stonehouse, Monaco, Feldmann, Foxwell: Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP. in Blood 2004
Human Polyclonal TIRAP Primary Antibody für ELISA, WB - ABIN251287
Farina, Krumbholz, Giese, Hartmann, Aloisi, Meinl: Preferential expression and function of Toll-like receptor 3 in human astrocytes. in Journal of neuroimmunology 2005
Human Polyclonal TIRAP Primary Antibody für IHC (p), WB - ABIN880289
Rolf, Kariminia, Ivison, Reid, Schultz: Heterodimer-specific TLR2 stimulation results in divergent functional outcomes in B-cell precursor acute lymphoblastic leukemia. in European journal of immunology 2015
Human Polyclonal TIRAP Primary Antibody für IF (p), IHC (p) - ABIN873277
Wang, Schwab, Fan, Seagroves, Buolamwini: Chemoprevention Activity of Dipyridamole in the MMTV-PyMT Transgenic Mouse Model of Breast Cancer. in Cancer prevention research (Philadelphia, Pa.) 2013
Zebrafish Tirap adaptor lacks the phosphatidylinositol 4,5-bisphosphate binding motif, which could partially explain zebrafish insensitivity to lipopolysaccharide, hence its resulting inability to activate downstream Toll (zeige TLR4 Antikörper)-like receptor signaling.
The major allele A of rs2511521 located in DRD2 (zeige DRD2 Antikörper) and the minor allele T of rs625413 located in TIRAP are significantly associated with increased risk of food addiction in overweight/obese subjects with low/zero food addiction symptoms.
Combined targeting of UBAP1 (zeige UBAP1 Antikörper) and toll (zeige TLR4 Antikörper)-like receptor adaptors TIRAP and MyD88 (zeige MYD88 Antikörper) by Pseudomonas aeruginosa PumA (zeige BBC3 Antikörper) impedes both cytokine and toll (zeige TLR4 Antikörper)-like receptor signalling, highlighting a novel strategy for innate immune evasion.
Epistatic interaction between MyD88 (zeige MYD88 Antikörper) and TIRAP against Helicobacter pylori.
Presence of at least one copy of the TIRAP (2054C > T) variant may be associated with severity of bronchopulmonary dysplasia among preterm neonates.
TIRAP polymorphisms are associated with progression and survival of patients with symptomatic myeloma.
This present meta-analysis suggests TIRAP C539T polymorphism is significantly correlated with reduced risk of TB infection, with stronger effect in European.
The TIRAP S180L and TLR9 (zeige TLR9 Antikörper) -1486 T>C polymorphism showed no association with systemic lupus erythematosus (SLE) risk, but they influenced SLE phenotype.
Evaluated the possible association between TIRAP rs1893352 and rs8177374 (S180L) gene polymorphisms and pulmonary tuberculosis in a sample of Iranian population.
TIRAP rs81777374 is associated with resistance to pulmonary tuberculosis.
Data indicate that TcpB (NP_540591) may mimic the function of TIRAP through their similar TIR domain structures.
TIRAP plays a functional role in transducing LPS (zeige IRF6 Antikörper) signaling from TLR-4 (zeige TLR4 Antikörper) to downstream effector molecules involved in NF-kappaB (zeige NFKB1 Antikörper) activation, and TIRAP promotes apoptotic signaling
Our key findings provide novel insights into the mechanism of action of heterotrimeric complex (PKCdelta (zeige PKCd Antikörper)-TIRAP-p38 (zeige CRK Antikörper)) in proinflammatory cytokine expression, which controls the development of the inflammatory trigger in stimulated macrophages.
Results suggest that TIR domain-containing adaptor protein positively regulated BV2 (zeige DNAH9 Antikörper) microglial M1 polarization through toll-like receptor 4 (zeige TLR4 Antikörper) -mediated Transforming Growth Factor-Beta-Activated Kinase 1 (zeige MAP3K7 Antikörper)/I-Kappa-B Kinase /Nuclear Factor of Kappa Light Polypeptide Gene Enhancer in B-Cells (TAK1 (zeige NR2C2 Antikörper)/IKK (zeige CHUK Antikörper)/NF-kappaB (zeige NFKB1 Antikörper)), mitogen-activated protein kinases and Akt (zeige AKT1 Antikörper) signalling pathways.
The adapter Mal (encoded by TIRAP) has appeared crucial for the cytokine production by Ly6C(lo) but not by Ly6C(hi) monocytes. The protein Mal was necessary to induce cytokine synthesis by Ly6C(lo) monocytes after triggering TLR2 or TLR9 (zeige TLR9 Antikörper).
genetic polymorphism is associated with interferon-gamma (zeige IFNG Antikörper) signaling and susceptibility to infections
TIRAP/Mal deficiency significantly inhibited the activity of titanium particles with adherent bacterial debris to stimulate in vivo osteolysis and in vitro cytokine mRNAs and secretion.
A critical role for the TLR signaling adapter Mal in alveolar macrophage-mediated protection against Bordetella pertussis.
The D-helix peptide, 2R9, also potently inhibited TLR4 (zeige TLR4 Antikörper), TLR7 (zeige TLR7 Antikörper), and TLR9 (zeige TLR9 Antikörper), but not TLR3 (zeige TLR3 Antikörper) or TNF-alpha (zeige TNF Antikörper) signaling. Cell imaging, co-immunoprecipitation, and in vitro studies demonstrated that 2R9 preferentially targets TIRAP.
MyD88 adaptor (zeige MYD88 Antikörper)-like (Mal) functions in the epithelial barrier and contributes to intestinal integrity via protein kinase C (zeige PKC Antikörper).
our data reveal a differential, but inflammation-independent, requirement for Mal and MyD88 during TLR2-promoted gastric tumourigenesis.
Mal is essential for the maintenance of intestinal homeostasis and expression of Mal in nonhematopoietic cells prevents chronic intestinal inflammation that may predispose to colon neoplasia.
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants\; however, not all variants have been fully described.
MyD88 adapter-like protein
, Toll-interleukin 1 receptor domain-containing adaptor protein
, toll/interleukin-1 receptor domain-containing adapter protein
, TIR domain-containing adaptor protein
, Toll-like receptor adaptor protein
, adapter protein wyatt
, adaptor protein Wyatt
, toll-interleukin 1 receptor domain-containing adaptor protein
, TIR domain-containing adapter protein
, Toll-like receptor 4 adaptor protein
, myD88 adapter-like protein