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this study shows that STAT6 (zeige STAT6 Proteine) negatively regulates IFNphi1 production by attenuating the kinase activity of TANK-binding kinase 1
Fish IRF6 (zeige IRF6 Proteine) is distinguished from the homolog of mammals by being a positive regulator of IFN transcription and phosphorylated by MyD88 (zeige MYD88 Proteine) and TBK1, suggesting that differences in the IRF6 (zeige IRF6 Proteine) regulation pattern exist between lower and higher vertebrates.
Given the critical roles of TBK1, important regulatory mechanisms are required to regulate its activity. Among these, Optineurin (Optn (zeige OPTN Proteine)) was shown to negatively regulate the interferon (zeige IFNA Proteine) response, in addition to its important role in membrane trafficking, protein secretion, autophagy and cell division.
we detected no statistical difference in age at diagnosis or maximum IOP when we compared patients with a TBK1 gene duplication and patients with a TBK1 gene triplication.
Human T-lymphotropic virus 1 Tax (zeige CNTN2 Proteine) protein impairs K63-linked ubiquitination of STING and disrupted the interactions between STING and TBK1 to evade host innate immunity.
we investigated a large European study population of 2,538 European FTD (zeige FTL Proteine)-ALS (zeige IGFALS Proteine) spectrum patients to get a deeper appreciation of the mutation frequency, mutation spectrum, and the genotype-phenotype profile of TBK1 patient carriers.
These results outline a novel mechanism for the control of TBK1 activity and suggest USP1 (zeige USP1 Proteine)-UAF1 (zeige WDR48 Proteine) complex as a potential target for the prevention of viral diseases.
TRIM9s undergoes Lys (zeige LYZ Proteine)-63-linked auto-polyubiquitination and serves as a platform to bridge GSK3beta to TBK1, leading to the activation of IRF3 (zeige IRF3 Proteine) signaling.
YPEL5 silencing enhanced the induction of IFNB1 (zeige IFNB1 Proteine) by pattern recognition receptors and phosphorylation of TBK1/IKBKE (zeige IKBKE Proteine) kinases, whereas co-immunoprecipitation experiments revealed that YPEL5 interacted physically with IKBKE (zeige IKBKE Proteine).
ZIKV infection of neuroepithelial stem cells and radial glial cells causes centrosomal depletion and mitochondrial sequestration of phospho-TBK1 during mitosis.
High TBK1 expression is associated with Lung cancer.
Our results highlight an unexpected role of the Golgi apparatus in innate immunity as a key subcellular gateway for TBK1 activation after RNA virus infection.
IL-17 (zeige IL17A Proteine) inhibits adipogenesis where a lack of IL-17 (zeige IL17A Proteine) ameliorates glucose metabolism. As well, the inhibition of TBK1 reduces inflammation induced by IL-17 (zeige IL17A Proteine). Therefore, IL-17 (zeige IL17A Proteine) may be involved in the development of obesity and metabolic dysfunction in a TBK1-dependent manner.
Data show that TBK1 directly interacts with Exo84 (zeige EXO84 Proteine) through the coiled-coil domain of TBK1 and helical domain of Exo84 (zeige EXO84 Proteine), and knockdown of TBK1 blocked insulin (zeige INS Proteine)-stimulated glucose uptake and GLUT4 (zeige SLC2A4 Proteine) translocation.
The TBK1 Y179A mutant failed to rescue type I IFN production by virally infected RAW264.7 macrophages deficient in TBK1
HERP (zeige HERPUD1 Proteine) Binds TBK1 To Activate Innate Immunity and Repress Virus Replication in Response to Endoplasmic Reticulum Stress
these studies reveal an additional regulatory function of TRIM8 (zeige TRIM8 Proteine) in innate immune responses: TRIM8 (zeige TRIM8 Proteine) catalyzes polyubiquitination of TRIF (zeige RNF138 Proteine), resulting in disruption of TRIF (zeige RNF138 Proteine)-TBK1 interaction
TBK1 regulates p16 expression and retinal ganglion cell senescence.
USP38 inhibits type I interferon signaling by editing TBK1 ubiquitination through NLRP4 signalosome.
The authors report that Raf kinase inhibitory protein (RKIP (zeige PEBP1 Proteine)) is essential for TBK1 activation and type I interferon (zeige IFNA Proteine) production triggered by viral infection.
Upon stimulation with poly(I:C), malaria parasite-infected red blood cells (iRBCs), or vesicular stomatitis virus (VSV), FOSL1 (zeige FOSL1 Proteine) "translocated" from the nucleus to the cytoplasm, where it inhibited the interactions between TNF receptor-associated factor 3 (TRAF3 (zeige TRAF3 Proteine)), TIR domain-containing adapter inducing IFN-beta (zeige IFNB1 Proteine) (TRIF (zeige RNF138 Proteine)), and Tank-binding kinase 1 (TBK1) via impairing K63-linked polyubiquitination of TRAF3 (zeige TRAF3 Proteine) and TRIF (zeige RNF138 Proteine).
TBK1 complexes required for the phosphorylation of IRF3 (zeige IRF3 Proteine) and the production of interferon-beta (zeige IFNB1 Proteine) have been identified.
The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors.
serine/threonine-protein kinase TBK1
, TANK-binding kinase 1
, NF-kappa-B-activating kinase
, TANK binding kinase 1
, serine/threonine protein kinase TBK1
, serine/threonine-protein kinase TBK1-like
, NF-kB-activating kinase