PTPN1 Proteine (PTPN1)

Bezeichnung:
Protein tyrosine Phosphatase, Non-Receptor Type 1 Proteine (PTPN1)
Auf www.antikoerper-online.de finden Sie aktuell 22 Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) Proteine von 11 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen PTPN1 Antikörper (251) und PTPN1 Kits (36) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 322 PTPN1 Produkte verfügbar.
Synonyme:
CPTP1, Ptp, PTP-1B, PTP-HA2, ptp1b, PTPN1, wu:fk54h03
alle Proteine anzeigen Gen GeneID UniProt
PTPN1 5770 P18031
PTPN1 19246 P35821
PTPN1 24697 P20417

Weitere Synonyme anzeigen

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Am meisten referenzierte PTPN1 Proteine

  1. Human PTPN1 Protein expressed in Escherichia coli (E. coli) - ABIN2002547 : Frangioni, Beahm, Shifrin, Jost, Neel: The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence. in Cell 1992 (PubMed)
    Zeige alle 4 Referenzen für 2002547

  2. Human PTPN1 Protein expressed in Escherichia coli (E. coli) - ABIN666832 : Chernoff, Schievella, Jost, Erikson, Neel: Cloning of a cDNA for a major human protein-tyrosine-phosphatase. in Proceedings of the National Academy of Sciences of the United States of America 1990 (PubMed)

Weitere Proteine zu PTPN1 Interaktionspartnern

Human Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) Interaktionspartner

  1. Data suggest TrxR1 (zeige TXNRD1 Proteine) and NADPH (zeige NQO1 Proteine) directly protect PTP1B from inactivation by oxidation; this protection is independent of TRX1 (zeige MLL Proteine) and PRX2 (zeige PRDX2 Proteine); this protection is blocked by auranofin (an inhibitor of TrxR1 (zeige TXNRD1 Proteine) and requires an intact selenocysteine residue in TrxR1 (zeige TXNRD1 Proteine). (TrxR1 (zeige TXNRD1 Proteine) = thioredoxin reductase 1 (zeige TXNRD1 Proteine); PTP1B = protein tyrosine phosphatase (zeige ACP1 Proteine), non-receptor type 1; TRX1 (zeige MLL Proteine) = thioredoxin-1; PRX2 (zeige PRDX2 Proteine) = paired related homeobox 2 (zeige PRRX2 Proteine) protein)

  2. Regulation of platelet-activating factor-mediated PTP1B activation by a Janus kinase 2/ calpain pathway has been reported.

  3. PTP1B was overexpressed in over 70% of breast cancer tissues, correlating with patients with estrogen receptor (ER (zeige ESR1 Proteine))-negative, progesterone receptor (PR (zeige PGR Proteine))-negative, and human epidermal growth factor receptor (zeige EGFR Proteine) 2 (HER2 (zeige ERBB2 Proteine))-positive tumors. The data also showed that both tumor size and lymph node metastasis were significantly higher in patients with a higher level of PTP1B.

  4. PTP1B uses conformational and dynamic allostery to regulate its activity. Both conformational rigidity and dynamics are essential for controlling protein activity.

  5. PTP1BDelta6 is a positive regulator of JAK (zeige JAK3 Proteine)/STAT (zeige STAT1 Proteine) signaling in classical Hodgkin lymphoma cells.(

  6. In PTP1B and VHR (zeige DUSP3 Proteine), two new allosteric clusters were identified in each enzyme.

  7. PTP1B/RNF213 (zeige RNF213 Proteine)/alpha-KGDD pathway is critical for survival of HER2 (zeige ERBB2 Proteine)(+) breast cancer, and possibly other malignancies, in the hypoxic tumour microenvironment

  8. data for the first time demonstrate a calpain/PTP1B/VEGFR2 negative feedback loop in the regulation of VEGF-induced angiogenesis. Modulation of local PTP1B and/or calpain activities may prove beneficial in the treatment of impaired wound healing in diabetes.

  9. Data show that cichoric acid (CHA (zeige TCFL5 Proteine)) is a competitive inhibitor that binds in the active site of protein tyrosine phosphatase 1B (PTP1B), and chlorogenic acid (CGA (zeige CGA Proteine)), while a noncompetitive inhibitor, binds in the second aryl phosphate binding site, rather than the predicted benzfuran binding pocket.

  10. stimulation of the DOCK180 (zeige DOCK1 Proteine) pathway represents an alternative mechanism of PTP1B inhibitor-stimulated endothelial cell motility, which does not require concomitant VEGFR2 (zeige KDR Proteine) activation as a prerequisite.

Mouse (Murine) Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) Interaktionspartner

  1. The results suggest a deficiency of PTP1B improves hypothalamic insulin (zeige INS Proteine) sensitivity resulting in the attenuation of AgRP (zeige AGRP Proteine) mRNA expression under HFD conditions.

  2. cadherin 2 (CDH2 (zeige CDH2 Proteine)) and CDH4 (zeige CDH4 Proteine) cooperate to regulate radial migration in mouse brain via the protein tyrosine phosphatase 1B (PTP1B) and alpha- and beta-catenins.

  3. this paper shows that PTP1B specifically regulates IgE-mediated STAT5 (zeige STAT5A Proteine) pathway, but is redundant in influencing mast cell function in vivo

  4. PTP1B/RNF213 (zeige RNF213 Proteine)/alpha-KGDD pathway is critical for survival of HER2 (zeige ERBB2 Proteine)(+) breast cancer, and possibly other malignancies, in the hypoxic tumour microenvironment

  5. data for the first time demonstrate a calpain/PTP1B/VEGFR2 negative feedback loop in the regulation of VEGF-induced angiogenesis. Modulation of local PTP1B and/or calpain activities may prove beneficial in the treatment of impaired wound healing in diabetes.

  6. These findings reveal a novel role for pancreatic PTP1B in cerulein- and arginine-induced acute pancreatitis.

  7. POMC (zeige POMC Proteine)-Ptp1b deletion increases plasma TNF-alpha (zeige TNF Proteine) levels

  8. Data show that protein tyrosine phosphatase 1B (PTP1B)-deficiency enhanced JAK2 (zeige JAK2 Proteine)-STAT3 (zeige STAT3 Proteine) signaling in hypothalamic microglia and attenuated inflammation.

  9. Taken together, the data presented here suggest that PTP1B is essential for proper differentiation of ES cells into cardiomyocytes.

  10. This study demonstrates that PTP1B is an important positive regulator of neuroinflammation

Cow (Bovine) Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) Interaktionspartner

  1. data for the first time demonstrate a calpain/PTP1B/VEGFR2 negative feedback loop in the regulation of VEGF-induced angiogenesis. Modulation of local PTP1B and/or calpain activities may prove beneficial in the treatment of impaired wound healing in diabetes.

PTPN1 Protein Überblick

Protein Überblick

The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation.

Alternative names and synonyms associated with PTPN1

  • protein tyrosine phosphatase, non-receptor type 1 (PTPN1)
  • protein tyrosine phosphatase, non-receptor type 1 (Ptpn1)
  • protein tyrosine phosphatase, non-receptor type 1 (ptpn1)
  • CPTP1 Protein
  • Ptp Protein
  • PTP-1B Protein
  • PTP-HA2 Protein
  • ptp1b Protein
  • PTPN1 Protein
  • wu:fk54h03 Protein

Bezeichner auf Proteinebene für PTPN1

protein tyrosine phosphatase, non-receptor type 1 , tyrosine-protein phosphatase non-receptor type 1 , tyrosine-protein phosphatase non-receptor type 1-like , protein tyrosine phosphatase, placental , protein-tyrosine phosphatase 1B , protein-protein-tyrosine phosphatase HA2 , protein-tyrosine phosphatase HA2 , PTP-1B , fk54h03 , protein tyrosine phosphatase 1b , non-receptor protein tyrosine phosphatase , phosphoprotein phosphatase , tyrosine phosphatase 1B

GENE ID SPEZIES
469970 Pan troglodytes
702016 Macaca mulatta
100172151 Pongo abelii
100354834 Oryctolagus cuniculus
100387823 Callithrix jacchus
100481720 Ailuropoda melanoleuca
5770 Homo sapiens
19246 Mus musculus
24697 Rattus norvegicus
30081 Danio rerio
444514 Xenopus laevis
395688 Gallus gallus
477263 Canis lupus familiaris
396667 Sus scrofa
508658 Bos taurus
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