anti-IRF5 (IRF5) Antikörper

Human Interferon Regulatory Factor 5 (IRF5) Interaktionspartner

1. IRF5 rs2004640 polymorphism is associated with systemic lupus erythematosus susceptibility in different ethnic groups; its prevalence is ethnicity dependent [meta-analysis]

2. We define mechanisms wherein common IRF5 genetic variants modulate bacterial clearance, thereby highlighting that immune-mediated disease risk IRF5 carriers might be relatively protected from microbial-associated diseases.

3. The IRF5 is an important therapeutic target of systemic lupus erythematosus (SLE), and selective suppression of its activity and expression may potentially lead to the development of new therapies.

4. IRF3 and IRF7 bind to many interferon-stimulated response element (ISRE)-type sites in the virus-response elements (VREs) of IFN promoters. However, strikingly, IRF5 does not bind the VREs.

5. Transcriptomic analyses of plasmacytoid dendritic cells (pDCs) show that the partitioning of TLR7/IRF5 and RLR/IRF3 pathways confers differential gene expression and immune cytokine production in pDCs

6. We confirmed that the IRF5 risk and non-risk haplotypes exert differential effects in myeloid cells, including an increased susceptibility to apoptosis conferred by the risk haplotype for systemic lupus erythematosus.

7. The distinct role of IRF5 in the intricate signaling network downstream of TLR8.IRF5 signaling is important for the expression of IL-1beta, TNFalpha, IL-6, IL-12, and IL-23 and therefore essential for mounting TH1 and TH17 responses.

8. the IRF5 rs2004640 polymorphism was not a risk factor for systemic lupus erythematosus in population from south India

9. we demonstrated for the first time an association between IRF5 rs 2004640 G/T alleles and predisposing to juvenile idiopathic arthritis. Understanding the role of IRF5 in rheumatic arthritis might help identify biological pathways of importance in the pathogenesis of this disease.

10. A possible cross-reaction between IRF5/EBV homologous antigens and shifts in T cell balance disrupted by anti-IL-2 Abs.

11. study suggests a novel role for interferon regulatory factor 5 (IRF5) in the regulation of the inflammatory response in human myometrium

12. In IAV-infected patients, miR-302a expression was down-regulated, whereas IRF-5 expression was up-regulated. Taken together, this work uncovers and defines a signaling pathway implicated in an IAV-induced cytokine storm.

13. Analysis of clinical HCC specimens supports a pathologic role for IRF5 in HCV-induced HCC, as IRF5 expression was down-regulated in livers from HCV-positive versus HCV-negative HCC patients or healthy donor livers. These results identify IRF5 as an important suppressor of HCV replication and HCC pathogenesis.

14. Results indicated that IFR5 variants rs77571059 and rs2004640 and haplotype GTAA were associated with the susceptibility to CAP and rs77571059 was related to the severity of the disease, suggesting that IFR5 variants may contribute to the pathogenesis of community-acquired pneumonia (CAP), and may serve as prognostic markers of CAP susceptibility and outcome.

15. IRF5 and its related inflammatory cytokines are associated with the severity, prognosis, and causative pathogen of CAP patients.

16. this study shows that interferon regulatory factor 5 regulates the expression of matrix metalloproteinase-3 in human chondrocytes

17. IFR5 variants may contribute as a host factor in determining the pathogenesis in chronic HBV infections.

18. The presence of the interferon regulatory factor 5 rs2004640 T allele increases the risk of nephritis development in Egyptian children with systemic lupus erythematosus.

19. IRF5 was an adverse independent prognostic factor for both overall survival and recurrence free survival in patients with non-metastatic ccRCC.

20. Data suggest that IRAK4 activity regulates activation of IRF5, TAK1, and IKKB in monocytes; IRAK4 activation of TAK1-IKKB-IRF5 axis leads to induction of cytokines and interferons following TLR7/TLR8 stimulation. (IRAK4 = interleukin-1 receptor-associated kinase 4; IRF5 = interferon regulatory factor-5; TAK1 = MAPK kinase kinase 7; IKKB = I-kappa B kinase; TLR = toll-like receptor)

Mouse (Murine) Interferon Regulatory Factor 5 (IRF5) Interaktionspartner

1. This study provides novel insights into the distinct and unique innate immune and immune gene regulatory program directed by IRF5.

2. IRF5 was a regulator of age-associated B cells in autoimmune settings

3. The GEF-H1-IKKepsilon-IRF5 signaling axis functions independent of NOD-like receptors and is critically required for the recognition of intracellular peptidoglycans and host defenses against Listeria monocytogenes.

4. Scavenger receptor class A is regulated by pathogens and suppresses IRF5 nuclear translocation by direct interaction. Reduced abundance of nuclear IRF5 shifts macrophage polarization from M1 towards M2, which subsequently switches T-helper responses from type 1 to type 2.

5. Aged mice expressed higher IRF5 levels in the ischemic brains, suggesting that aging has a significant influence on stroke outcomes in mice, which is probably mediated by age-specific inflammatory responses.

6. this study shows a critical role for IRF5 in regulating allergic airway inflammation

7. BCG increased membrane expression of TRIM59 through the TLR2/ TLR4/IRF5 pathway in RAW264.7 macrophage cell line.

8. IRF5 and IRF5 disease-risk variants increase glycolysis and human m1 macrophage polarization by regulating proximal signaling and Akt2 activation.

9. these results reveal a role for Lyn as a specific suppressor of the TLR-MyD88-IRF5 pathway and illustrate the importance of fine-tuning IRF5 activity for the maintenance of immune homeostasis

10. IRF5 siRNA reverses pancreatitis-induced activation of lung macrophages from M1 phenotype to M2 phenotype in severe acute pancreatitis associated with acute lung injury.

11. Our data show that miR-146b targets IRF5, resulting in the regulation of macrophage activation. Furthermore, miR-146b deficient mice developed intestinal inflammation with enhanced M1 macrophage polarization.

12. data suggest that IRF5 plays a causal role in inflammation, fibrosis and impaired vascular EC function in Tsk/+ mice

13. study sheds light on the TLR4-IRF5 pathway in the pathology of SSc with clinical implications of targeting the IRF5 pathways in the suppression of disease development

14. Collectively, these results indicate a key role for IRF-5 in modulating the host antiviral response in peripheral organs that controls bunyavirus neuroinvasion in mice.

15. studies extend prior ones suggesting that inhibiting IRF5 might be useful for chronic macrophage-induced inflammation and suggest that IRF5 blockade would ameliorate more acute forms of inflammation, including lung injury

16. IRF5 plays an important role in the development of disease in the MRL/lpr mouse model of lupus in the absence of the DOCK2 mutation and that IRF5 is required for the transition from mature B cells to plasma cells.

17. IRF5 expression in microglia is regulated by IRF8. IRF5 directly upregulates P2RX4 expression on microglia in peripheral nerve injury, and may play a role in neuropathic pain.

18. PAR1 suppression of IRF5 and IL-12/23 secretion by macrophages provides a novel mechanism by which the host suppresses the mucosal Th1 and Th17 response to H. pylori infection.

19. This study uncovers a new function for IRF5 in controlling the relative mass of different adipose tissue depots and thus insulin sensitivity in obesity.

20. IKKbeta is an IRF5 kinase that instigates inflammation