anti-IRAK2 (IRAK2) Antikörper

Human Interleukin-1 Receptor-Associated Kinase 2 (IRAK2) Interaktionspartner

1. This study for the first time ever reports the association of IRAK2 rs3844283, IRAK2 rs708035, and the corresponding haplotypes with rheumatoid arthritis.

2. IRAK2 L392V showed intact binding to, but impaired ubiquitination of, tumor necrosis factor (zeige TNF Antikörper) receptor-associated factor 6, a vital step in signal transduction

3. This for the first time implicates human IRAK2 in a human disease and highlights the R214G IRAK2 variant as a potential novel and broadly applicable biomarker for disease or as a therapeutic intervention point.

4. Human miR (zeige MLXIP Antikörper)-373 is silenced by histone modification in lung cancer cells and is a negative regulator of the mesenchymal phenotype through downstream IRAK2 and LAMP1 (zeige LAMP1 Antikörper) target genes.

5. Results suggest that D431E-IRAK2 (interleukin-1 receptor-associated kinase-2) increases NF-kappaB (zeige NFKB1 Antikörper) activation by promoting TRAF6 (zeige TRAF6 Antikörper) ubiquitination by enhancing TNF Receptor-Associated Factor 6 (TRAF6 (zeige TRAF6 Antikörper))-IRAK2 interaction.

6. These findings demonstrate an unexpected linkage of the innate immunity machinery to unfolded protein response signaling, revealing IRAK2 as a novel amplifier of the IRE1 (zeige ERN1 Antikörper) pathway.

7. Human interleukin-1 receptor-associated kinase-2 is essential for Toll (zeige TLR4 Antikörper)-like receptor-mediated transcriptional and post-transcriptional regulation of tumor necrosis factor alpha (zeige TNF Antikörper).

8. analysis of differential regulation of interleukin-1 receptor-associated kinase-1 (IRAK-1 (zeige IRAK1 Antikörper)) and IRAK-2 by microRNA-146a and NF-kappaB (zeige NFKB1 Antikörper) in stressed human astroglial cells and in Alzheimer disease

9. Our data show that interleukin-1R-associated kinase 2 is a novel and critical component of TGFbeta (zeige TGFB1 Antikörper) signaling.

10. the crystal structure of the MyD88 (zeige MYD88 Antikörper)-IRAK4 (zeige IRAK4 Antikörper)-IRAK2 death domain (DD) complex, which surprisingly reveals a left-handed helical oligomer that consists of 6 MyD88 (zeige MYD88 Antikörper), 4 IRAK4 (zeige IRAK4 Antikörper) and 4 IRAK2 DDs

Mouse (Murine) Interleukin-1 Receptor-Associated Kinase 2 (IRAK2) Interaktionspartner

1. In summary, lipopolysaccharide activates a nuclear function of IRAK2 that facilitates the assembly of nuclear export machinery to export selected inflammatory mRNAs to the cytoplasm for translation.

2. These findings demonstrate an unexpected linkage of the innate immunity machinery to unfolded protein response signaling, revealing IRAK2 as a novel amplifier of the IRE1 (zeige ERN1 Antikörper) pathway.

3. Our results establish that the IRAK2-TRAF6 (zeige TRAF6 Antikörper) interaction is rate limiting for the late, but not the early phase of cytokine production in bone marrow-derived macrophages and plasmacytoid dendritic cells

4. IRAK2 plays a key role in the TLR9 (zeige TLR9 Antikörper)-mediated transcriptional regulation of Irak-m (zeige IRAK3 Antikörper) expression by sustaining activation of PKD1 (zeige PKD1 Antikörper) and NF-kappaB (zeige NFKB1 Antikörper)

5. IRAK-2 mediates pathology in a CD4 T cell specific manner by promoting Th17 cell development through enhancement of IL-1beta-induced activation of transcription factors RORgammat and BATF.

6. the kinase activity of IRAK2 is required for the optimal activation of mitogen-activated protein kinase (zeige MAPK1 Antikörper) signaling, which regulates cytokine and chemokine (zeige CCL1 Antikörper) production at posttranscriptional levels.

7. IRAK2 is a negative regulator of Toll (zeige TLR4 Antikörper)-like receptor (TLR)9 (zeige TLR9 Antikörper)-induced interferon (zeige IFNA Antikörper) production in plasmacytoid dendritic cells.

8. Alternative splicing of the Irak2 gene in mice will generate agonistic or antagonistic Irak2 isoforms, which is likely to have consequences for the regulation of Toll (zeige TLR4 Antikörper)-like receptors signaling.

9. TRAF6 (zeige TRAF6 Antikörper) and interleukin receptor-associated kinase 2 are novel binding partners for PS1 (zeige PSEN1 Antikörper), and IL-1R1 is a new substrate for presenilin-dependent gamma-secretase cleavage

10. These results reveal that IRAK2 is required for LPS (zeige TLR4 Antikörper)-mediated post-transcriptional control of cytokine and chemokine (zeige CCL1 Antikörper) expression, which plays an essential role in TLR4 (zeige TLR4 Antikörper)-induced septic shock.