This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009].
Nakajima, Okazaki, Yamakawa, Kikuno, Ohara, Nagase: "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 9, Issue 3, pp. 99-106, (2002) (PubMed).
Ben-Yosef, Francomano: "Characterization of the human talin (TLN) gene: genomic structure, chromosomal localization, and expression pattern." in: Genomics, Vol. 62, Issue 2, pp. 316-9, (2000) (PubMed).
Aliase für TLN1 Proteine
talin 1 (TLN1) Proteine talin 1 (Tln1) Proteine talin 1 (tln1) Proteine talin 1 L homeolog (tln1.L) Proteine Talin 1 (Bm1_56490) Proteine talin-1 (LOC100380665) Proteine ILWEQ Proteine sb:cb854 Proteine talin-1 Proteine TLN Proteine Tln Proteine tln Proteine TLN1 Proteine wu:fb05c02 Proteine