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present the cases of two siblings with a novel mutation of TSHB. One of them was c.40A>G (rs10776792) which is a very common variation that is also seen in healthy individuals, the other was c.94G>A at codon 32 of exon 2 which resulted in a change from glutamic acid to lysine (p.E32K
The serum levels of IL-8 (zeige IL8 Proteine), MIP-1 alpha (zeige CCL3 Proteine), MIP-1 beta (zeige CCL4 Proteine), MMP-8 (zeige MMP8 Proteine), Resistin (zeige RETN Proteine), FLRG (zeige FSTL3 Proteine), and BCAM (zeige BCAT2 Proteine) were significantly higher in breast cancer patients, but LAP and TSH-beta levels were lower.
results provide novel evidence of TSHB as a paracrine factor that is modulated in parallel with cholesterol metabolism in human adipose tissue
In hyperthyroidism, bone marrow resident macrophages have the potential to exert enhanced osteoprotective effects by oversecreting a TSH-beta splice variant.
In the context of metabolic syndrome, a higher TSH within the euthyroid range confers an increased leptin/adiponectin ratio, a proposed marker of atherosclerosis susceptibility and adipocyte dysfunction.
the distribution of 1(st) trimester TSH and evaluate its association with perinatal outcomes and future development of maternal thyrotoxicosis, is reported.
Data suggest that the subtle thyroid-stimulating hormone (TSH) reduction could possibly reflect minor hypothalamic-pituitary damage.
analysis of a single nucleotide substitution in TSHbeta related to clinical euthyroidism [family case report]
Findings defined the immune-derived functional TSHb splice variant that resided in the thyroid of patients with Hashimoto's thyroiditis (HT), which exerted the unique effects on the pathogenesis of the disease.
Serum TSH was associated with pulse wave velocity on population level when adjusted with age and sex.
Nitric oxide decreases TSH-induced FoxE1 (zeige FOXE1 Proteine) expression, thus repressing the transcripcional activation of TPO (zeige TPO Proteine) gene.
identification for the first time that ADAM10 is a TSHR cleavage enzyme and demonstration that TSH regulates its activation
subcutaneous adipose tissue Tshb expression levels correlated directly with circulating cholesterol levels
Oncogene (zeige RAB1A Proteine)-induced senescence is initiated in Braf (zeige BRAF Proteine)(V600E)-induced papillary thyroid cancers when TSH is normal. TSH reduces p53 (zeige TP53 Proteine) expression by upregulating the PI3K/AKT (zeige AKT1 Proteine) pathway and inhibiting OIS, resulting in tumor progression.
The observations indicate that the experimental system possesses responsiveness of the TSHbeta expression to melatonin.
PPARalpha (zeige PPARA Proteine) modulates the TSH beta-subunit (zeige POLG Proteine) mRNA expression in thyrotrope cells.
Tshb gene transcription was attenuated in MED1 (zeige MBD4 Proteine) mutant mice in which the nuclear receptor-binding ability of MED1 (zeige MBD4 Proteine) was specifically disrupted.
Disruption of type II deiodinase in thyrotrophs decreases their sensitivity to T4 thyroid hormone and thus elevates serum TSH.
Thyrotropin-releasing hormone (zeige TRH Proteine) altered the basal expression of the TSHbeta gene and the responsiveness of the gene to thyroid hormone (zeige PTH Proteine).
PBF (zeige PTTG1IP Proteine) is the first protein to interact with the critical TH transporter MCT8 (zeige MCT8 Proteine) and modulate its function in vivo
thyroid-stimulating hormone and thyroid-stimulating hormone receptor (zeige TSHR Proteine) antibodies have roles in osteoclastogenesis
Data demonstrate that Eya3 (zeige EYA3 Proteine) and its partner Six1 (zeige SIX1 Proteine) synergistically activate TSHbeta expression and that this activation is further enhanced by Tef (zeige TEF Proteine) and Hlf (zeige HLF Proteine).
mutation of the human homolog is a rare cause of hereditary hypothyrodism
thyrotropin beta chain
, thyrotropin subunit beta
, thyroid stimulating hormone, beta subunit
, thyroid-stimulating hormone subunit beta
, thyroid stimulating hormone, beta polypeptide
, thyrotropin beta subunit
, thyroid-stimulating hormone beta subunit
, thyrotropin beta-subunit