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Serum macro TSH level is associated with sleep quality in patients with cardiovascular risks.
present the cases of two siblings with a novel mutation of TSHB. One of them was c.40A>G (rs10776792) which is a very common variation that is also seen in healthy individuals, the other was c.94G>A at codon 32 of exon 2 which resulted in a change from glutamic acid to lysine (p.E32K
The serum levels of IL-8, MIP-1 alpha, MIP-1 beta, MMP-8, Resistin, FLRG, and BCAM were significantly higher in breast cancer patients, but LAP and TSH-beta levels were lower.
results provide novel evidence of TSHB as a paracrine factor that is modulated in parallel with cholesterol metabolism in human adipose tissue
In hyperthyroidism, bone marrow resident macrophages have the potential to exert enhanced osteoprotective effects by oversecreting a TSH-beta splice variant.
In the context of metabolic syndrome, a higher TSH within the euthyroid range confers an increased leptin/adiponectin ratio, a proposed marker of atherosclerosis susceptibility and adipocyte dysfunction.
the distribution of 1(st) trimester TSH and evaluate its association with perinatal outcomes and future development of maternal thyrotoxicosis, is reported.
Data suggest that the subtle thyroid-stimulating hormone (TSH) reduction could possibly reflect minor hypothalamic-pituitary damage.
analysis of a single nucleotide substitution in TSHbeta related to clinical euthyroidism [family case report]
Findings defined the immune-derived functional TSHb splice variant that resided in the thyroid of patients with Hashimoto's thyroiditis (HT), which exerted the unique effects on the pathogenesis of the disease.
Serum TSH was associated with pulse wave velocity on population level when adjusted with age and sex.
Higher TSH levels are associated with less favorable lipid levels in children
In cases with isolated central congenital hypothyroidism and undetectably low TSH serum concentrations, a TSHbeta gene deletion should be considered
Epistasis between single nucleotide polymorphisms within the TSHB and ADAMTS16 genes may increase the risk of premature ovarian failure in Korean women.
High Thyroid Stimulating Hormone levels are associated with papillary thyroid carcinoma.
bTSH Induces IL-6 Protein and mRNA in Orbital Fibroblasts and Fibrocytes
The use of these age-specific reference intervals for TSH, especially in those over 70 years old, would result in the reclassification of many TSH results from "abnormal" to "normal" and avoid unnecessary treatment.
In Hashimoto's thyroiditis the hTSHbeta splice variant exists in human serum and dimerises with TSHalpha.
Data suggest that a progressive increase in TSH are predictive factors for thyroid failure in Hashimoto's thyroiditis (HT) patients.
Data suggest that likelihood of papillary thyroid carcinoma is reduced when serum TSH is lower, as in thyroid autonomy, and increased when serum TSH is higher, as in thyroid autoimmunity. [Meta-Analysis; REVIEW]
Nitric oxide decreases TSH-induced FoxE1 expression, thus repressing the transcripcional activation of TPO gene.
identification for the first time that ADAM10 is a TSHR cleavage enzyme and demonstration that TSH regulates its activation
subcutaneous adipose tissue Tshb expression levels correlated directly with circulating cholesterol levels
Oncogene-induced senescence is initiated in Braf(V600E)-induced papillary thyroid cancers when TSH is normal. TSH reduces p53 expression by upregulating the PI3K/AKT pathway and inhibiting OIS, resulting in tumor progression.
The observations indicate that the experimental system possesses responsiveness of the TSHbeta expression to melatonin.
PPARalpha modulates the TSH beta-subunit mRNA expression in thyrotrope cells.
Tshb gene transcription was attenuated in MED1 mutant mice in which the nuclear receptor-binding ability of MED1 was specifically disrupted.
Disruption of type II deiodinase in thyrotrophs decreases their sensitivity to T4 thyroid hormone and thus elevates serum TSH.
Thyrotropin-releasing hormone altered the basal expression of the TSHbeta gene and the responsiveness of the gene to thyroid hormone.
PBF is the first protein to interact with the critical TH transporter MCT8 and modulate its function in vivo
thyroid-stimulating hormone and thyroid-stimulating hormone receptor antibodies have roles in osteoclastogenesis
Data demonstrate that Eya3 and its partner Six1 synergistically activate TSHbeta expression and that this activation is further enhanced by Tef and Hlf.
Data show that the -588/-560 region of nuclear factor I is involved in the insulin-mediated repression of thyroid stimulating hormone beta.
multiple domains of Pit-1 are required for full synergy with GATA-2 and sequences between the two binding sites contribute to co-occupancy with both factors on the proximal TSH beta promoter
sythesis of thyrotropin in CD45+ hematopoietic bone marrow cells and involvement in the regulation of TNF-alpha by CD11b(-) BM cells
TSH is a negative regulator of skeletal remodeling.
N-CoR and TRbeta cooperate in the regulation of the TSHbeta gene and this ligand-dependent repression is mediated by the LXXLL motif in N-CoR
TRH is absolutely required for both TSH and TH synthesis but is not necessary for thyrotroph cell development
TSHbeta gene is maximally activated by a combination of TRAP220, Pit-1, GATA-2 that act via both protein-DNA and protein-protein interactions.
findings have direct functional implications for understanding a TSH immune-endocrine circuit in the small intestine
Bone marrow cells produce a novel TSHb splice variant that is upregulated in the thyroid following systemic virus infection.
expression in the pars tuberalis controlled by melatonin and the molecular clockwork
mutation of the human homolog is a rare cause of hereditary hypothyrodism
thyrotropin beta chain
, thyrotropin subunit beta
, thyroid stimulating hormone, beta subunit
, thyroid-stimulating hormone subunit beta
, thyroid stimulating hormone, beta polypeptide
, thyrotropin beta subunit
, thyroid-stimulating hormone beta subunit
, thyrotropin beta-subunit